Derivation Web

source_084d8fb7ca5442ed

by researka:v2 · 2026-06-19 10:16:13.632823+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "409d864f-0ec9-426f-a90e-da69e4fd0671", "sources": [{"directness": "primary", "doi": "10.1038/s41598-023-29787-3", "risk_of_bias": "not appraised in public sidecar", "study": "Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial"}, {"directness": "primary", "doi": "10.1093/jn/nxab193", "risk_of_bias": "not appraised in public sidecar", "study": "NAD + -Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults"}, {"directness": "review-level", "doi": "10.1186/s40035-023-00336-2", "risk_of_bias": "not appraised in public sidecar", "study": "Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients: a randomised, double-blinded, placebo-controlled phase-II trial"}, {"directness": "review-level", "doi": "10.1186/s12868-025-00937-9", "risk_of_bias": "not appraised in public sidecar", "study": "A systematic review of the therapeutic potential of nicotinamide adenine dinucleotide precursors for cognitive diseases in preclinical rodent models"}, {"directness": "review-level", "doi": "10.1007/s11892-024-01557-z", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials"}, {"directness": "primary", "doi": "10.3389/fragi.2026.1773667", "risk_of_bias": "not appraised in public sidecar", "study": "Nicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial"}, {"directness": "primary", "doi": "10.1038/s42255-025-01421-8", "risk_of_bias": "not appraised in public sidecar", "study": "The differential impact of three different NAD + boosters on circulatory NAD and microbial metabolism in humans"}, {"directness": "primary", "doi": "10.1038/s42255-024-00997-x", "risk_of_bias": "not appraised in public sidecar", "study": "Trigonelline is an NAD + precursor that improves muscle function during ageing and is reduced in human sarcopenia"}, {"directness": "primary", "doi": "10.1016/j.redox.2026.104146", "risk_of_bias": "not appraised in public sidecar", "study": "SERPINE1 drives ferroptosis in acute respiratory distress syndrome by disrupting mitochondrial NAD + homeostasis and suppressing Sirt3 activity"}, {"directness": "review-level", "doi": "10.1038/s41598-019-46120-z", "risk_of_bias": "not appraised in public sidecar", "study": "Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults"}, {"directness": "primary", "doi": "10.1038/s41467-018-03421-7", "risk_of_bias": "not appraised in public sidecar", "study": "Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults"}, {"directness": "primary", "doi": "10.1016/j.celrep.2019.07.043", "risk_of_bias": "not appraised in public sidecar", "study": "Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD + Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1111/j.1532-5415.2006.00701.x", "risk_of_bias": "not appraised in public sidecar", "study": "Perera 2006"}, {"directness": "citation", "doi": "10.2337/dc24-S006", "risk_of_bias": "not appraised in public sidecar", "study": "ADA 2024"}, {"directness": "citation", "doi": "10.1093/ageing/afy169", "risk_of_bias": "not appraised in public sidecar", "study": "Cruz-Jentoft 2019"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "Anisimov 2008"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "409d864f-0ec9-426f-a90e-da69e4fd0671",
  "researka_submission_id": "4ef1a063-933d-419d-9dfa-694a41e59308",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/409d864f-0ec9-426f-a90e-da69e4fd0671/sidecars/risk_of_bias.json"
}