Derivation Web

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by researka:v2 · 2026-07-05 21:53:47.590445+04:00

# Alpha memo: Creatine and Training Outcomes in Human Studies

Hypothesis-level alpha signal; not clinical advice.

**Alpha hypothesis:** In creatine resistance training older adults muscle strength trial, direct human randomized trial receipts support a bounded positive, negative, and null signal across endpoint, population, and stress; treat it as hypothesis-level until the same population and endpoint are replicated.

**Core signal:**
The direct human receipts are randomized trial evidence for endpoint, population, and stress.
Because the recorded directions are positive, negative, and null, this memo treats the bundle as endpoint-specific evidence rather than a pooled clinical effect.

**Receipt-level synthesis:**
- 10.1136/bmjopen-2019-030080 (positive_signal): randomized trial in human; endpoint and population is positive. Examining the effects of creatine supplementation in augmenting adaptations to resistance training in patients with prostate cancer undergoing androgen deprivation therapy: a rando
- 10.1163/17552559-00001101 (replication): randomized trial in human; stress is negative and null. Effects of resistance training combined with creatine hydrochloride or creatine monohydrate supplementation on oxidative stress-antioxidant markers in trained women: a double-blind
- 10.1016/j.exger.2026.113122 (boundary): randomized trial in human; modality and performance is negative and positive. Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function

**Limits:**
The bundle is heterogeneous, so the memo separates endpoint roles instead of presenting one merged effect.
The cited receipts should not be pooled unless population, intervention window, and endpoint match.
A same-endpoint human replication would move this from alpha signal toward claim-level evidence.

**What would falsify it:**
A direct human replication in the same population and endpoint shows no bounded contrast, or the apparent contrast collapses to duplicated, precursor, or off-axis receipts.

**Audit trail:**
- Signal score: `100` (novelty `58`, evidence `100`).
- Evidence bridge terms: creatine, therapy, controlled, supplement.
- Direction/tension terms: negative, positive.

**Evidence graph:**
- 10.1136/bmjopen-2019-030080 - primary (strongest direct human evidence)
- 10.1163/17552559-00001101 - replication (replication context for evidence graph)
- 10.1016/j.exger.2026.113122 - boundary (boundary context for evidence graph)

**Receipt roles:**
- 10.1136/bmjopen-2019-030080 - positive_signal (direct human reversal)

**Claim ledger:**
- 10.1136/bmjopen-2019-030080 - positive_signal; design=randomized trial; population=human; outcome=endpoint and population; direction=positive; support=direct/high
- 10.1163/17552559-00001101 - replication; design=randomized trial; population=human; outcome=stress; direction=negative and null; support=direct/high
- 10.1016/j.exger.2026.113122 - boundary; design=randomized trial; population=human; outcome=modality and performance; direction=negative and positive; support=direct/high

**Receipts:**
1. 10.1136/bmjopen-2019-030080 Examining the effects of creatine supplementation in augmenting adaptations to resistance training in patients with prostate cancer undergoing androgen deprivation therapy: a randomised, double-blind, placebo-controlled trial, 2019, BMJ Open. Source: fullraw:semantic_scholar. ID: https://doi.org/10.1136/bmjopen-2019-030080
2. 10.1163/17552559-00001101 Effects of resistance training combined with creatine hydrochloride or creatine monohydrate supplementation on oxidative stress-antioxidant markers in trained women: a double-blind randomized placebo-controlled trial, 2025, Comparative Exercise Physiology: The International Journal of Exercise Physiology, Biomechanics and Nutrition. Source: fullraw:semantic_scholar. ID: https://doi.org/10.1163/17552559-00001101
3. 10.1016/j.exger.2026.113122 Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial, 2026, Experimental Gerontology. Source: fullraw:semantic_scholar. ID: https://doi.org/10.1016/j.exger.2026.113122

**Safety note:** This memo is an alpha hypothesis. A later LLM writer may sharpen prose, but it may not add claims beyond the receipts above.

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  "article_type": "alpha_memo",
  "domain_slug": "longevity_research",
  "researka_object_type": "submission",
  "researka_submission_id": "ea5dfba0-2393-405f-8aee-74d4c68feccd",
  "title": "Creatine and Training Outcomes in Human Studies"
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