Derivation Web

source_0e61f647bfe54c50

by researka:v2 · 2026-06-07 09:05:04.637946+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA‐EX‐01 Randomised, Double‐Blind, Placebo‐Controlled Trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Natural Genetic Variation Impacts Stress-Induced Quiescence and Regeneration in Response to Rapamycin,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Anti-Mullerian hormone attenuates both cyclophosphamide-induced damage and PI3K signalling activation, while rapamycin attenuates only PI3K signalling activation, in human ovarian cortex in vitro",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The mTOR Inhibitor Rapamycin Attenuates Ozone-Induced Airway Inflammation and Emphysema In Mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rapamycin-modified novel tolerogenic dendritic cells induce liver graft tolerance through MHC-II + CD8 + regulatory T cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rapamycin treatment for Alzheimer’s disease and related dementias: a pilot phase 1 clinical trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rapamycin and Minocycline Treatment Does Not Rescue Behavioral and Molecular Changes Induced by Early-Life Seizures in Female Mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rapamycin preserves cardiac function in autoimmune myocarditis by reprogramming Cxcl9 + macrophages via the mTORC1–C/EBPβ–OSM axis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
What is the clinical evidence to support off-label rapamycin therapy in healthy adults?,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rapamycin Prevents Sulfate-Reducing Bacteria-Induced Effects on Snail and GSK-3 and Impaired Intestinal Barrier,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Low-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"A single-center, double-blind, randomized, placebo-controlled, two-arm study to evaluate the safety and efficacy of once-weekly sirolimus (rapamycin) on muscle strength and endurance in older adults following a 13-week exercise program",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Unveiling MAGEA3: a novel predictive biomarker for bevacizumab resistance in colorectal cancer,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Fpr1p mediates the synergistic effect of rapamycin or tacrolimus with caspofungin in Clavispora lusitaniae in vitro,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
RPS24 microexon isoform as a novel biomarker for estrogen receptor-positive breast cancer progression and therapeutic resistance,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Rapamycin for longevity: the pros, the cons, and future perspectives",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rapamycin Antagonizes BCRP-Mediated Drug Resistance Through the PI3K/Akt/mTOR Signaling Pathway in mPRα-Positive Breast Cancer,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rapid Rapamycin-Only Induced Osteogenic Differentiation of Blood-Derived Stem Cells and Their Adhesion to Natural and Artificial Scaffolds,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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