Derivation Web

source_0ed70051348f432a

by researka:v2 · 2026-06-28 04:45:41.747293+04:00

{"content_hash": "sha256:0b8eec7084df48cfcdfd0f940d669e121eae847e31c36324d04ef97b4789e950", "edges": [{"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_1", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_2", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_3", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_4", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_5", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_6", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_7", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_8", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_9", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_10", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_11", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_12", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_13", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_14", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_15", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_16", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_17", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_18", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_19", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_20", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_21", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_22", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_23", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_24", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_25", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_26", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_27", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_28", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_29", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_30", "type": "contains_claim"}], "nodes": [{"id": "054f72de-a886-4506-a529-11d92344f009", "title": "Adjacent Evidence Brief: Telomere Cancer Effects — full paper", "type": "publication"}, {"id": "claim_1", "text": "This synthesis tests the thesis that evidence for Telomere Cancer Effects is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation.", "type": "claim"}, {"id": "claim_2", "text": "Evidence-honesty note: The retained evidence has no direct interventional hard-endpoint evidence; indirect, review-level, adjacent, or mechanistic sources are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.", "type": "claim"}, {"id": "claim_3", "text": "This paper synthesizes evidence on telomere cancer effects across 25 included source papers and 826 high-confidence extracted claims.", "type": "claim"}, {"id": "claim_4", "text": "The evidence profile contains no sources classified primarily as direct interventional hard-endpoint evidence, 24 adjacent clinical sources, and 1 mechanistic or model-system source, with 3 cross-study disagreements across the evidence base.", "type": "claim"}, {"id": "claim_5", "text": "Positive study-level signals are summarized in the frailty outcome class; null signals are summarized in the immune and inflammation and mechanism outcome classes; negative signals are summarized in the dosing and pharmacokinetics outcome class; mixed or heterogeneous signals are summarized in the contextual adjacent evidence, mortality and survival, and longevity outcome classes. The paper therefore reports a source-directness and outcome-class map rather than a pooled effect.", "type": "claim"}, {"id": "claim_6", "text": "The conclusion is narrower: the retained evidence maps associations, mechanisms, and candidate endpoints for follow-up; it does not establish clinical benefit, therapeutic actionability, or anti-aging efficacy.", "type": "claim"}, {"id": "claim_7", "text": "For Telomere Cancer Effects, what does the retained evidence show about prognostic or risk-marker associations, causal or mechanistic evidence, treatment or intervention relevance across prognostic and survival-marker evidence, treatment or intervention-response evidence, causal-risk and Mendelian-randomization evidence, and are those outcome-class source-level signals directionally consistent enough for clinical actionability once unclear direction coding, adjacent/contextual source roles, and directness limits are considered?", "type": "claim"}, {"id": "claim_8", "text": "This manuscript is reported as a Thin-corpus evidence brief. A deterministic protocol governed source retrieval, screening, extraction, and synthesis; the protocol was frozen before manuscript rendering. The full audit trail is in the supplementary `methods_pack.json` and the timestamped submission directory `synthesis-telomere_cancer_effects-v06-DAILY-2026-06-28T00-39-28Z`.", "type": "claim"}, {"id": "claim_9", "text": "The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating. Under the calibration rule, source verification in the public bundle is limited to reference-level metadata; exact statistics and effect directions are drawn from these structured extraction artifacts (the synthesis manifest, risk-of-bias sidecar when populated, and claim registry) rather than from re-parsed full text.", "type": "claim"}, {"id": "claim_10", "text": "Risk-of-bias framework assignment follows study design (RoB-2 for RCTs, ROBINS-I for non-randomised studies, AMSTAR-2 for systematic reviews / meta-analyses). Public appraisal claims are limited to populated `risk_of_bias.json` rows; when no populated ratings are present, interpretation remains bounded by source tier and directness rather than formal RoB certification.", "type": "claim"}, {"id": "claim_11", "text": "Evidence-tension synthesis: claims grouped by outcome class (contextual adjacent evidence, dosing and pharmacokinetics, frailty, immune and inflammation, longevity, mechanism, mortality and survival); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.", "type": "claim"}, {"id": "claim_12", "text": "Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.", "type": "claim"}, {"id": "claim_13", "text": "Source directness breakdown: 0/25 retained sources directly address the stated topic and aging-relevant hard endpoints; 25/25 are adjacent, contextual, review-level, or mechanistic and are used only to bound interpretation. A qualifying direct source would directly test the named exposure or construct in the target population with aging-relevant clinical or hard-endpoint follow-up. Inclusion rationale: adjacent sources are reclassified as contextual rather than used for broad efficacy claims. Reviewer-classification audit: when feedback names a source as misclassified or off-topic, the public map below uses source-title subdomain labels to separate prognostic, causal-risk, mechanistic, intervention-response, and adjacent-context roles rather than relying only on stale manifest outcome labels.", "type": "claim"}, {"id": "claim_14", "text": "Alhareeri 2020: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2.", "type": "claim"}, {"id": "claim_15", "text": "Jaeger 2024: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2.", "type": "claim"}, {"id": "claim_16", "text": "Markozannes 2022: outcome=Immune and Inflammation; direction=null; directness=review; tier=B2.", "type": "claim"}, {"id": "claim_17", "text": "Li 2026: outcome=Contextual Adjacent Evidence; direction=positive; directness=indirect; tier=B2.", "type": "claim"}, {"id": "claim_18", "text": "Davidson-Swinton 2026: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2.", "type": "claim"}, {"id": "claim_19", "text": "Langsenlehner 2026: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2.", "type": "claim"}, {"id": "claim_20", "text": "Gil-Korilis 2026: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2.", "type": "claim"}, {"id": "claim_21", "text": "Cheng 2026: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2.", "type": "claim"}, {"id": "claim_22", "text": "Bhat 2023: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2.", "type": "claim"}, {"id": "claim_23", "text": "Brown 2026: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2.", "type": "claim"}, {"id": "claim_24", "text": "Chen 2023: outcome=Contextual Adjacent Evidence; direction=null; directness=review; tier=B2.", "type": "claim"}, {"id": "claim_25", "text": "Alqaisi 2026: outcome=Contextual Adjacent Evidence; direction=null; directness=review; tier=B2.", "type": "claim"}, {"id": "claim_26", "text": "Wan 2023: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2.", "type": "claim"}, {"id": "claim_27", "text": "Genetta 2026: outcome=Contextual Adjacent Evidence; direction=null; directness=indirect; tier=B2.", "type": "claim"}, {"id": "claim_28", "text": "Andreikos 2024: outcome=Contextual Adjacent Evidence; direction=unclear; directness=review; tier=B2.", "type": "claim"}, {"id": "claim_29", "text": "Song 2022: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2.", "type": "claim"}, {"id": "claim_30", "text": "Aierken 2026: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2.", "type": "claim"}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "type": "source", "url": "https://doi.org/10.37349/etat.2025.1002289", "year": 2025}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "type": "source", "url": "https://doi.org/10.1186/s13058-020-01368-6", "year": 2020}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "type": "source", "url": "https://doi.org/10.3390/nu16172963", "year": 2024}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "type": "source", "url": "https://doi.org/10.1186/s13148-026-02137-6", "year": 2026}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "type": "source", "url": "https://doi.org/10.1186/s12916-022-02246-y", "year": 2022}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1038/s41514-026-00352-2", "effect": "not extracted", "endpoint": "not extracted", "id": "source_6", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Aging and increased cancer risk: exploring the potential of LE8 score to mitigate risk", "type": "source", "url": "https://doi.org/10.1038/s41514-026-00352-2", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1182/blood.2025031287", "effect": "not extracted", "endpoint": "not extracted", "id": "source_7", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Lymphoid malignancy and clonality in the POT1-mediated long telomere syndrome ∗", "type": "source", "url": "https://doi.org/10.1182/blood.2025031287", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1038/s41598-026-36205-x", "effect": "not extracted", "endpoint": "not extracted", "id": "source_8", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Leukocyte telomere attrition following radiotherapy in prostate cancer: a prospective study", "type": "source", "url": "https://doi.org/10.1038/s41598-026-36205-x", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1177/15347354231154267", "effect": "not extracted", "endpoint": "not extracted", "id": "source_9", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of Traditional Korean Medicine Oncotherapy on the Survival, Quality of Life, and Telomere Length: A Prospective Cohort Study", "type": "source", "url": "https://doi.org/10.1177/15347354231154267", "year": 2023}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1186/s10020-026-01423-6", "effect": "not extracted", "endpoint": "not extracted", "id": "source_10", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Unraveling the telomere-mitochondrial axis in colorectal cancer: Results from a prospectively followed cohort", "type": "source", "url": "https://doi.org/10.1186/s10020-026-01423-6", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1155/ijog/5301600", "effect": "not extracted", "endpoint": "not extracted", "id": "source_11", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Integrative Analysis of Telomere‐Related Genes Reveals Prognostic Signatures in Laryngeal Cancer", "type": "source", "url": "https://doi.org/10.1155/ijog/5301600", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3390/cancers18030490", "effect": "not extracted", "endpoint": "not extracted", "id": "source_12", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Leukocyte Telomere Length Variants Are Independently Associated with Survival of Patients with Colorectal Cancer", "type": "source", "url": "https://doi.org/10.3390/cancers18030490", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.14174", "effect": "not extracted", "endpoint": "not extracted", "id": "source_13", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "DNA methylation‐based telomere length is associated with HIV infection, physical frailty, cancer, and all‐cause mortality", "type": "source", "url": "https://doi.org/10.1111/acel.14174", "year": 2024}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1186/s12885-023-11387-z", "effect": "not extracted", "endpoint": "not extracted", "id": "source_14", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India", "type": "source", "url": "https://doi.org/10.1186/s12885-023-11387-z", "year": 2023}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1093/neuonc/noaf300", "effect": "not extracted", "endpoint": "not extracted", "id": "source_15", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "SMARCAL1 is a targetable synthetic lethal therapeutic vulnerability in ATRX-deficient gliomas that use alternative lengthening of telomeres", "type": "source", "url": "https://doi.org/10.1093/neuonc/noaf300", "year": 2026}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1111/acel.13874", "effect": "not extracted", "endpoint": "not extracted", "id": "source_16", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Association between genetically determined telomere length and health‐related outcomes: A systematic review and meta‐analysis of Mendelian randomization studies", "type": "source", "url": "https://doi.org/10.1111/acel.13874", "year": 2023}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.3390/curroncol33020074", "effect": "not extracted", "endpoint": "not extracted", "id": "source_17", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Telomerase Activity in Melanoma: Impact on Cancer Cell Proliferation Kinetics, Tumor Progression, and Clinical Therapeutic Strategies—A Scoping Review", "type": "source", "url": "https://doi.org/10.3390/curroncol33020074", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3390/cancers18030499", "effect": "not extracted", "endpoint": "not extracted", "id": "source_18", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "ZEB1 Promotes Alternate Lengthening of Telomeres at Multiple Levels", "type": "source", "url": "https://doi.org/10.3390/cancers18030499", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1371/journal.pone.0286219", "effect": "not extracted", "endpoint": "not extracted", "id": "source_19", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Mendelian randomization study on the causal relationship between leukocyte telomere length and prostate cancer", "type": "source", "url": "https://doi.org/10.1371/journal.pone.0286219", "year": 2023}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.3390/ijms25169000", "effect": "not extracted", "endpoint": "not extracted", "id": "source_20", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The Association between Telomere Length and Head and Neck Cancer Risk: A Systematic Review and Meta-Analysis", "type": "source", "url": "https://doi.org/10.3390/ijms25169000", "year": 2024}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3389/fgene.2022.931785", "effect": "not extracted", "endpoint": "not extracted", "id": "source_21", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Association Between Telomere Length and Skin Cancer and Aging: A Mendelian Randomization Analysis", "type": "source", "url": "https://doi.org/10.3389/fgene.2022.931785", "year": 2022}, {"comparator": "not extracted", "directness": "primary", "doi": "10.7150/jca.129718", "effect": "not extracted", "endpoint": "not extracted", "id": "source_22", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Integrative Bulk and Single-Cell Transcriptome Profiling of Telomere-Related Genes Reveals a Robust Prognostic Signature and Immunotherapeutic Landscape in Neuroblastoma", "type": "source", "url": "https://doi.org/10.7150/jca.129718", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3389/fcell.2026.1797677", "effect": "not extracted", "endpoint": "not extracted", "id": "source_23", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Telomere-driven dysfunctional changes in gynecological cancers: mechanistic insights, biomarker potential, and therapeutic targeting", "type": "source", "url": "https://doi.org/10.3389/fcell.2026.1797677", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3389/fimmu.2024.1452946", "effect": "not extracted", "endpoint": "not extracted", "id": "source_24", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer", "type": "source", "url": "https://doi.org/10.3389/fimmu.2024.1452946", "year": 2024}, {"comparator": "not extracted", "directness": "primary", "doi": "10.18632/oncotarget.8796", "effect": "not extracted", "endpoint": "not extracted", "id": "source_25", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The impact of adjuvant chemotherapy in older breast cancer patients on clinical and biological aging parameters", "type": "source", "url": "https://doi.org/10.18632/oncotarget.8796", "year": 2016}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_26", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_27", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_28", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_29", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.", "type": "source", "url": null, "year": null}], "publication_id": "054f72de-a886-4506-a529-11d92344f009", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 25, "included": 25, "included_or_retained": 25, "screened": 25, "wording": "25 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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