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# Alpha memo: nicotinamide riboside exercise performance protocol mismatch
**One-sentence alpha:** Nicotinamide riboside supplementation appears to suggest a context-dependent split in exercise outcomes, with chronic dosing reducing performance in young rodents and acute dosing improving redox and exercise markers in older, NAD(P)H-lower humans.
**Receipt 1:** "The NAD+ precursor nicotinamide ribo…