Derivation Web

source_13154076bf874198

by researka:v2 · 2026-07-03 10:17:53.357213+04:00

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anticancer serum proteome response and improves metabolic syndrome"}, {"directness": "primary", "doi": "10.3390/nu18020238", "risk_of_bias": "not appraised in public sidecar", "study": "Metabolic and Orexin-A Responses to Ketogenic Diet and Intermittent Fasting: A 12-Month Randomized Trial in Adults with Obesity"}, {"directness": "review-level", "doi": "10.3390/nu18111799", "risk_of_bias": "not appraised in public sidecar", "study": "Age-Specific Analysis of the Effects of Intermittent Fasting on Body Composition and Cardiometabolic Markers in Healthy Adults and Individuals with Overweight or Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"}, {"directness": "primary", "doi": "10.3389/fendo.2023.1143799", "risk_of_bias": "not appraised in public sidecar", "study": "Six-month periodic fasting does not affect somatosensory nerve function in type 2 diabetes patients"}, {"directness": "review-level", "doi": "10.3389/fnut.2026.1772836", "risk_of_bias": "not appraised in public sidecar", "study": "Optimal dosage of exercise combined with intermittent fasting for body composition and cardiometabolic health in adults: a systematic review and multilevel meta-analysis"}, {"directness": "review-level", "doi": "10.3389/fnut.2026.1818813", "risk_of_bias": "not appraised in public sidecar", "study": "The effects of intermittent fasting on BMI, fasting blood glucose, and blood pressure in women with overweight or obesity: a systematic review and meta-analysis with dose–response relationships"}, {"directness": "primary", "doi": "10.3390/nu17142385", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of 4:3 Intermittent Fasting on Eating Behaviors and Appetite Hormones: A Secondary Analysis of a 12-Month Behavioral Weight Loss Intervention"}, {"directness": "review-level", "doi": "10.3389/fnut.2025.1664811", "risk_of_bias": "not appraised in public sidecar", "study": "Intermittent fasting improves metabolic outcomes in metabolic syndrome: a systematic review and meta-analysis with GRADE evaluation"}, {"directness": "review-level", "doi": "10.3390/nu17101689", "risk_of_bias": "not appraised in public sidecar", "study": "The Effectiveness of Time-Restricted Eating as an Intermittent Fasting Approach on Shift Workers’ Glucose Metabolism: A Systematic Review and Meta-Analysis"}, {"directness": "primary", "doi": "10.3390/nu16162663", "risk_of_bias": "not appraised in public sidecar", "study": "Twenty-Four Hour Glucose Profiles and Glycemic Variability during Intermittent Religious Dry Fasting and Time-Restricted Eating in Subjects without Diabetes: A Preliminary Study"}, {"directness": "primary", "doi": "10.3390/nu15234870", "risk_of_bias": "not appraised in public sidecar", "study": "Time-Restricted Fasting Improves Liver Steatosis in Non-Alcoholic Fatty Liver Disease—A Single Blinded Crossover Trial"}, {"directness": "review-level", "doi": "10.3390/ijerph19116698", "risk_of_bias": "not appraised in public sidecar", "study": "The Effectiveness of Intermittent Fasting, Time Restricted Feeding, Caloric Restriction, a Ketogenic Diet and the Mediterranean Diet as Part of the Treatment Plan to Improve Health and Chronic Musculoskeletal Pain: A Systematic Review"}, {"directness": "primary", "doi": "10.1002/oby.23568", "risk_of_bias": "not appraised in public sidecar", "study": "A meta‐analysis comparing the effectiveness of alternate day fasting, the 5:2 diet, and time‐restricted eating for weight loss"}, {"directness": "primary", "doi": "10.1186/s13063-023-07691-5", "risk_of_bias": "not appraised in public sidecar", "study": "The effects of intermittent fasting diet alone or in combination with probiotic supplementation in comparison with calorie-restricted diet on metabolic and hormonal profile in patients with polycystic ovary syndrome: study protocol for a randomized clinical trial"}, {"directness": "primary", "doi": "10.3390/nu13051523", "risk_of_bias": "not appraised in public sidecar", "study": "An Intermittent Fasting Mimicking Nutrition Bar Extends Physiologic Ketosis in Time Restricted Eating: A Randomized, Controlled, Parallel-Arm Study"}, {"directness": "primary", "doi": "10.3389/fpubh.2022.1017254", "risk_of_bias": "not appraised in public sidecar", "study": "Intermittent fasting and time-restricted eating role in dietary interventions and precision nutrition"}, {"directness": "primary", "doi": "10.1177/0260106017753487", "risk_of_bias": "not appraised in public sidecar", "study": "Eating behavior traits of successful weight losers during 12 months of alternate-day fasting: An exploratory analysis of a randomized controlled trial."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}]}

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}