Derivation Web

source_1687f16a10054e76

by researka:v2 · 2026-06-25 19:01:49.067157+04:00

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Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement that the source texts contain no directional findings; source-level positive, negative, or unclear findings should be interpreted through the coded outcome class, directness, and claim-count fields. The retained evidence has no direct interventional hard-endpoint evidence; indirect, review-level, adjacent, or mechanistic sources are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.", "type": "claim"}, {"id": "claim_3", "text": "This paper synthesizes evidence on Plant based diet biological age across 13 included source papers and 369 high-confidence extracted claims.", "type": "claim"}, {"id": "claim_4", "text": "The evidence profile contains no sources classified primarily as direct interventional hard-endpoint evidence, 13 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, with 9 cross-study disagreements across the evidence base.", "type": "claim"}, {"id": "claim_5", "text": "No single positive outcome class dominates the retained corpus; null signals cluster in the contextual adjacent evidence, longevity, safety and comorbidity outcome classes, and negative signals cluster in the longevity outcome class. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect.", "type": "claim"}, {"id": "claim_6", "text": "The conclusion is that Plant based diet biological age should be treated as a bounded geroscience hypothesis: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "type": "claim"}, {"id": "claim_7", "text": "This manuscript is reported as a Evidence brief. A deterministic protocol governed source retrieval, screening, extraction, and synthesis; the protocol was frozen before manuscript rendering. The full audit trail is in the supplementary `methods_pack.json` and the timestamped submission directory `synthesis-plant_based_diet_biological_age-v06-DAILY-2026-06-25T14-56-22Z`.", "type": "claim"}, {"id": "claim_8", "text": "The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating. Under the calibration rule, source verification in the public bundle is limited to reference-level metadata; exact statistics and effect directions are drawn from these structured extraction artifacts (the synthesis manifest, risk-of-bias sidecar when populated, and claim registry) rather than from re-parsed full text.", "type": "claim"}, {"id": "claim_9", "text": "Risk-of-bias framework assignment follows study design (RoB-2 for RCTs, ROBINS-I for non-randomised studies, AMSTAR-2 for systematic reviews / meta-analyses). Public appraisal claims are limited to populated `risk_of_bias.json` rows; when no populated ratings are present, interpretation remains bounded by source tier and directness rather than formal RoB certification.", "type": "claim"}, {"id": "claim_10", "text": "Evidence-tension synthesis: claims grouped by outcome class (cardiometabolic, contextual adjacent evidence, longevity, mortality and survival, safety and comorbidity); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.", "type": "claim"}, {"id": "claim_11", "text": "Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.", "type": "claim"}, {"id": "claim_12", "text": "Outcome-class note:** Contextual Adjacent Evidence denotes background, boundary-condition, or adjacent-outcome sources. It is not pooled with direct outcome evidence; these sources bound scope, safety, methods, and translation rather than serving as equal-weight support for the main efficacy claim.", "type": "claim"}, {"id": "claim_13", "text": "| Evidence domain | Corpus slice | Strongest signal | Directness | Main limitation |", "type": "claim"}, {"id": "claim_14", "text": "| Contextual Adjacent Evidence | n=4; claims=92 | no extracted directional signal in 4/4 sources | 3 indirect; 1 protocol | limited corpus depth in this outcome class |", "type": "claim"}, {"id": "claim_15", "text": "This evidence brief reports outcome packets as a map of retained evidence rather than as a full journal Results narrative or pooled effect estimate.", "type": "claim"}, {"id": "claim_16", "text": "6 included sources were assigned to this outcome class. Directional coding: negative=3, null=2, unclear=1. Directness coding: indirect=5, review=1.", "type": "claim"}, {"id": "claim_17", "text": "4 included sources were assigned to this outcome class. Directional coding: null=4. Directness coding: indirect=3, protocol=1.", "type": "claim"}, {"id": "claim_18", "text": "1 included source were assigned to this outcome class. Directional coding: null=1. Directness coding: indirect=1.", "type": "claim"}, {"id": "claim_19", "text": "1 included source were assigned to this outcome class. Directional coding: null=1. Directness coding: indirect=1.", "type": "claim"}, {"id": "claim_20", "text": "Verification note:** Reference-only or no-abstract records are treated as verification-limited context, not as equal-weight support for the main claim.", "type": "claim"}, {"id": "claim_21", "text": "The principal limitation is evidence-role imbalance. The retained corpus contains no sources classified primarily as direct interventional hard-endpoint evidence, 13 adjacent clinical sources, which means causal interpretation depends on how much weight is assigned to each evidence tier.", "type": "claim"}, {"id": "claim_22", "text": "A second limitation is endpoint heterogeneity. Study-level signals span the contextual adjacent evidence, longevity, and safety and comorbidity outcome classes; these domains cannot be pooled narratively without losing clinically relevant differences in measurement, population, and study design.", "type": "claim"}, {"id": "claim_23", "text": "This framing also preserves comparability across topics. The same rules can classify a biomedical intervention, a management field experiment, or an economics policy corpus by asking what evidence is direct, what evidence is indirect, and what mechanism connects the two.", "type": "claim"}, {"id": "claim_24", "text": "The final interpretation is therefore intentionally resistant to overstatement. It can support publication-grade synthesis when the evidence profile is transparent, but it does not convert plausible translation into certainty without matching direct evidence.", "type": "claim"}, {"id": "claim_25", "text": "For Plant based diet biological age, the final interpretation is deliberately tiered: the retained clinical and adjacent evidence profile defines a bounded geroscience rationale, but the corpus does not support treating mechanistic target engagement, intermediate biomarkers, and patient-relevant outcomes as interchangeable evidence. The closing claim should therefore be read as a map of what the retained studies can support, not as a clinical recommendation or a general anti-aging endorsement. Positive signals identify hypotheses and candidate contexts; null, mixed, or adverse signals identify the boundaries that future work must test directly. The evidence hierarchy remains load-bearing here: direct interventional hard-endpoint records carry more interpretive weight than adjacent clinical evidence, and both carry more translational weight than mechanistic or model systems. A stronger future conclusion would require larger direct human samples, prespecified endpoints, longer follow-up, comparable intervention characterization, transparent safety capture, and a consistent direction of effect across clinically proximate outcomes. Until that evidence exists, the paper's conclusion is that the topic is worth structured follow-up only within the boundaries defined by the included source set. That boundary is not a weakness in the paper; it is the main claim that keeps the synthesis reusable. Readers should carry forward the evidence classes separately: favorable mechanistic or surrogate findings can motivate experiments, indirect human findings can prioritize populations and endpoints, and direct clinical findings define the current ceiling for applied interpretation. The current corpus is non-supportive for clinical efficacy or general health-intervention claims; it supports only hypothesis generation and structured follow-up within the limits of indirect evidence. Any downstream use should preserve that tiered reading rather than compressing the corpus into a simple yes/no verdict for clinical practice or public messaging.", "type": "claim"}, {"id": "claim_26", "text": "This synthesis maps 13 included sources on Plant Based Diet Biological Age across 5 outcome classes and 9 cross-study disagreements. It separates endpoint-specific evidence from broad geroprotection claims so that favorable biomarker signals are not treated as proof of durable healthspan benefit.", "type": "claim"}, {"id": "claim_27", "text": "Across 13 curated reference papers, the evidence base for plant-based diets shows a context-dependent profile. Negative signals appear in: longevity. Null findings dominate: contextual other, longevity. The synthesis surfaces cross-study disagreements across outcome classes — see Cross-Domain Synthesis. The plant-based diet anti-aging case as currently constituted is incomplete: mechanistic plausibility coexists with mixed or sparse human-RCT evidence, and the boundary conditions remain to be established.", "type": "claim"}, {"id": "claim_28", "text": "The strongest unresolved contrast is the null vs negative between Wei 2025 and Longo 2025 on longevity (severity 4/5), which defines the boundary condition future studies must test rather than smooth over.", "type": "claim"}, {"id": "claim_29", "text": "Prior reviews in the corpus (Morawitz 2026) emphasize convergent signals on Plant Based Diet Biological Age. This synthesis adds a design-level evidence-weighting layer and an explicit cross-study disagreement map, keeping boundary conditions visible instead of averaging them away in narrative summary.", "type": "claim"}, {"id": "claim_30", "text": "| Evidence domain | Direct sources | Indirect / mechanism sources | Direction profile | Interpretation boundary |", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1002/cre2.70305", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The Mediating Role of Biological Age Advance in the Association Between Periodontitis and Mortality: Biological Aging Links Periodontitis to Mortality", "type": "source", "url": "https://doi.org/10.1002/cre2.70305", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1038/s41514-026-00377-7", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Imaging-derived biological age across multiple organs links to mortality and aging-related health outcomes", "type": "source", "url": "https://doi.org/10.1038/s41514-026-00377-7", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1093/oncolo/oyaf294", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of a whole food plant-based dietary intervention on cancer progression and inflammatory markers", "type": "source", "url": "https://doi.org/10.1093/oncolo/oyaf294", "year": 2025}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3389/fpubh.2026.1816971", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Association of biological age acceleration with cardiovascular disease and premature mortality: a population-based prospective cohort study", "type": "source", "url": "https://doi.org/10.3389/fpubh.2026.1816971", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/jch.70256", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Associations of Biological Age and Heart Age Accelerations With New‐Onset Stroke in Individuals With Cardiovascular‐Kidney‐Metabolic Syndrome Stages 0–3: Evidence From a Chinese Longitudinal Study", "type": "source", "url": "https://doi.org/10.1111/jch.70256", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1371/journal.pone.0334621", "effect": "not extracted", "endpoint": "not extracted", "id": "source_6", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Association of biological age acceleration with all-cause and cardiovascular mortality in HSV-positive adults: A population-based longitudinal cohort study", "type": "source", "url": "https://doi.org/10.1371/journal.pone.0334621", "year": 2025}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1007/s11357-023-00813-6", "effect": "not extracted", "endpoint": "not extracted", "id": "source_7", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Alpha-ketoglutarate supplementation and BiologicaL agE in middle-aged adults (ABLE)—intervention study protocol", "type": "source", "url": "https://doi.org/10.1007/s11357-023-00813-6", "year": 2023}, {"comparator": "not extracted", "directness": "primary", "doi": "10.2196/78243", "effect": "not extracted", "endpoint": "not extracted", "id": "source_8", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Deep Learning–Based Estimated Pulmonary Biological Age From Chest Computed Tomography Images in Healthy Adults: Model Development and Validation Study", "type": "source", "url": "https://doi.org/10.2196/78243", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1186/s13148-026-02067-3", "effect": "not extracted", "endpoint": "not extracted", "id": "source_9", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Tracking DNA methylation-based biological age over 8 years and its association with mortality in community-dwelling older adults", "type": "source", "url": "https://doi.org/10.1186/s13148-026-02067-3", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1186/s12877-025-06927-0", "effect": "not extracted", "endpoint": "not extracted", "id": "source_10", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Plant-based diets for older adults in care homes: a realist synthesis", "type": "source", "url": "https://doi.org/10.1186/s12877-025-06927-0", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1093/geroni/igaf122.962", "effect": "not extracted", "endpoint": "not extracted", "id": "source_11", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Biological Age and Psychological Distress: Health Disparities Between Midlife Jewish and Arab Adults", "type": "source", "url": "https://doi.org/10.1093/geroni/igaf122.962", "year": 2025}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1093/geroni/igaf122.1389", "effect": "not extracted", "endpoint": "not extracted", "id": "source_12", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Fasting Mimicking Diet Cycles, Regeneration, Biological Age, and Disease", "type": "source", "url": "https://doi.org/10.1093/geroni/igaf122.1389", "year": 2025}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1038/s41514-026-00429-y", "effect": "not extracted", "endpoint": "not extracted", "id": "source_13", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Mortality associated biological age improves independently of weight loss after bariatric surgery", "type": "source", "url": "https://doi.org/10.1038/s41514-026-00429-y", "year": 2026}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_14", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_15", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_16", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_17", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.", "type": "source", "url": null, "year": null}], "publication_id": "85440cfa-aa74-4ac3-983b-efad9e093f27", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 13, "included": 13, "included_or_retained": 13, "screened": 13, "wording": "13 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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