Derivation Web

source_173298c5ed7c4572

by researka:v2 · 2026-06-22 01:31:31.635996+04:00

{"publication_id": "9071bd4f-9969-4a7f-85ee-ae7c64682a16", "traces": [{"candidate_sources": [{"doi": "10.7554/elife.88080", "study": "The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent", "url": "https://pubmed.ncbi.nlm.nih.gov/37096321/"}, {"doi": "10.1111/acel.12203", "study": "Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart", "url": "https://pubmed.ncbi.nlm.nih.gov/24612461/"}, {"doi": "10.1139/h2012-091", "study": "Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.", "url": "https://pubmed.ncbi.nlm.nih.gov/22891896/"}, {"doi": "10.1002/jbmr.82", "study": "Caloric restriction leads to high marrow adiposity and low bone mass in growing mice", "url": "https://pubmed.ncbi.nlm.nih.gov/20229598/"}, {"doi": "10.1126/science.abk0297", "study": "Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice", "url": "https://pubmed.ncbi.nlm.nih.gov/35511946/"}], "claim": "Across 4 independently cited sources, the evidence converges on one bounded claim: caloric restriction modulates metabolic and endocrine biomarkers (IGF-1, FGF-21, glucose tolerance) in rodents. Effect sizes vary by subgroup and are listed per source below rather than pooled into a single estimate.", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.7554/elife.88080", "study": "The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent", "url": "https://pubmed.ncbi.nlm.nih.gov/37096321/"}, {"doi": "10.1111/acel.12203", "study": "Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart", "url": "https://pubmed.ncbi.nlm.nih.gov/24612461/"}, {"doi": "10.1139/h2012-091", "study": "Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.", "url": "https://pubmed.ncbi.nlm.nih.gov/22891896/"}, {"doi": "10.1002/jbmr.82", "study": "Caloric restriction leads to high marrow adiposity and low bone mass in growing mice", "url": "https://pubmed.ncbi.nlm.nih.gov/20229598/"}, {"doi": "10.1126/science.abk0297", "study": "Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice", "url": "https://pubmed.ncbi.nlm.nih.gov/35511946/"}], "claim": "Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.7554/elife.88080", "study": "The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent", "url": "https://pubmed.ncbi.nlm.nih.gov/37096321/"}, {"doi": "10.1111/acel.12203", "study": "Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart", "url": "https://pubmed.ncbi.nlm.nih.gov/24612461/"}, {"doi": "10.1139/h2012-091", "study": "Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.", "url": "https://pubmed.ncbi.nlm.nih.gov/22891896/"}, {"doi": "10.1002/jbmr.82", "study": "Caloric restriction leads to high marrow adiposity and low bone mass in growing mice", "url": "https://pubmed.ncbi.nlm.nih.gov/20229598/"}, {"doi": "10.1126/science.abk0297", "study": "Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice", "url": "https://pubmed.ncbi.nlm.nih.gov/35511946/"}], "claim": "The surprise is the bounded heterogeneity: the cited direct receipts do not support one uniform effect estimate, so the useful alpha is the specific receipt map and its unresolved spread.", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.7554/elife.88080", "study": "The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent", "url": "https://pubmed.ncbi.nlm.nih.gov/37096321/"}, {"doi": "10.1111/acel.12203", "study": "Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart", "url": "https://pubmed.ncbi.nlm.nih.gov/24612461/"}, {"doi": "10.1139/h2012-091", "study": "Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.", "url": "https://pubmed.ncbi.nlm.nih.gov/22891896/"}, {"doi": "10.1002/jbmr.82", "study": "Caloric restriction leads to high marrow adiposity and low bone mass in growing mice", "url": "https://pubmed.ncbi.nlm.nih.gov/20229598/"}, {"doi": "10.1126/science.abk0297", "study": "Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice", "url": "https://pubmed.ncbi.nlm.nih.gov/35511946/"}], "claim": "`fact_id=162990` (`A_core`) — 30% CR in young male mice decreased fat mass and improved glucose tolerance and insulin sensitivity doi=10.7554/elife.88080", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.7554/elife.88080", "study": "The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent", "url": "https://pubmed.ncbi.nlm.nih.gov/37096321/"}, {"doi": "10.1111/acel.12203", "study": "Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart", "url": "https://pubmed.ncbi.nlm.nih.gov/24612461/"}, {"doi": "10.1139/h2012-091", "study": "Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.", "url": "https://pubmed.ncbi.nlm.nih.gov/22891896/"}, {"doi": "10.1002/jbmr.82", "study": "Caloric restriction leads to high marrow adiposity and low bone mass in growing mice", "url": "https://pubmed.ncbi.nlm.nih.gov/20229598/"}, {"doi": "10.1126/science.abk0297", "study": "Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice", "url": "https://pubmed.ncbi.nlm.nih.gov/35511946/"}], "claim": "`fact_id=3904` (`A_core`) — proteome half-lives of old hearts significantly increased after short-term CR (30%) doi=10.1111/acel.12203", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.7554/elife.88080", "study": "The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent", "url": "https://pubmed.ncbi.nlm.nih.gov/37096321/"}, {"doi": "10.1111/acel.12203", "study": "Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart", "url": "https://pubmed.ncbi.nlm.nih.gov/24612461/"}, {"doi": "10.1139/h2012-091", "study": "Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.", "url": "https://pubmed.ncbi.nlm.nih.gov/22891896/"}, {"doi": "10.1002/jbmr.82", "study": "Caloric restriction leads to high marrow adiposity and low bone mass in growing mice", "url": "https://pubmed.ncbi.nlm.nih.gov/20229598/"}, {"doi": "10.1126/science.abk0297", "study": "Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice", "url": "https://pubmed.ncbi.nlm.nih.gov/35511946/"}], "claim": "_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.7554/elife.88080", "study": "The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent", "url": "https://pubmed.ncbi.nlm.nih.gov/37096321/"}, {"doi": "10.1111/acel.12203", "study": "Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart", "url": "https://pubmed.ncbi.nlm.nih.gov/24612461/"}, {"doi": "10.1139/h2012-091", "study": "Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.", "url": "https://pubmed.ncbi.nlm.nih.gov/22891896/"}, {"doi": "10.1002/jbmr.82", "study": "Caloric restriction leads to high marrow adiposity and low bone mass in growing mice", "url": "https://pubmed.ncbi.nlm.nih.gov/20229598/"}, {"doi": "10.1126/science.abk0297", "study": "Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice", "url": "https://pubmed.ncbi.nlm.nih.gov/35511946/"}], "claim": "Treat this as a receipt map for choosing the next extraction, not as evidence that the topic has one unified effect. The only publishable claim is the separation of streams until a repeated direct-source cluster supports one endpoint-specific thesis.", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.7554/elife.88080", "study": "The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent", "url": "https://pubmed.ncbi.nlm.nih.gov/37096321/"}, {"doi": "10.1111/acel.12203", "study": "Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart", "url": "https://pubmed.ncbi.nlm.nih.gov/24612461/"}, {"doi": "10.1139/h2012-091", "study": "Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.", "url": "https://pubmed.ncbi.nlm.nih.gov/22891896/"}, {"doi": "10.1002/jbmr.82", "study": "Caloric restriction leads to high marrow adiposity and low bone mass in growing mice", "url": "https://pubmed.ncbi.nlm.nih.gov/20229598/"}, {"doi": "10.1126/science.abk0297", "study": "Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice", "url": "https://pubmed.ncbi.nlm.nih.gov/35511946/"}], "claim": "_No direct opposing receipt was selected by this run. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._", "claim_id": "claim_8"}]}

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