Derivation Web

source_18683d268f014fc5

by researka:v2 · 2026-06-24 03:26:23.071237+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Spermidine and Rapamycin Reveal Distinct Autophagy Flux Response and Cargo Receptor Clearance Profile,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Spermidine Attenuates Neuroimmune Dysfunction in Gulf War Illness via Modulation of the Gut- Brain Axis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Whole Blood Spermine/Spermidine Ratio as a New Indicator of Sarcopenia Status in Older Adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
High-Dose Spermidine Supplementation Does Not Increase Spermidine Levels in Blood Plasma and Saliva of Healthy Adults: A Randomized Placebo-Controlled Pharmacokinetic and Metabolomic Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults—A Pilot Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"POLYamine treatment in elderly patients with Coronary Artery Disease (POLYCAD): study protocol for a Danish randomised, double-blind, placebo-controlled trial of spermidine treatment versus placebo",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Human Supplementation with AM3, Spermidine, and Hesperidin Enhances Immune Function, Decreases Biological Age, and Improves Oxidative–Inflammatory State: A Randomized Controlled Trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Spermidine improves seed viability in Allium mongolicum by regulating AmCS-mediated metabolic and antioxidant networks,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Exogenous Polyamines Only Indirectly Induce Stress Tolerance in Wheat Growing in Hydroponic Culture under Polyethylene Glycol-Induced Osmotic Stress,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The positive effect of spermidine in older adults suffering from dementia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
N8‐Acetylspermidine: A Polyamine Biomarker in Ischemic Cardiomyopathy With Reduced Ejection Fraction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Plasma Polyamines and Short‐Term Adverse Outcomes Among Patients With Ischemic Stroke: A Prospective Cohort Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Non-linear association between serum spermidine and mild cognitive impairment: Results from a cross-sectional and longitudinal study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
5-ALA localises to the autophagy compartment and increases its fluorescence upon autophagy enhancement through caloric restriction and spermidine treatment in human glioblastoma,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Functional and Biochemical Characterization of Spermidine Synthase CauSpe3 from Candidozyma auris,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
High Plasma Polyamine Levels Are Associated With an Increased Risk of Poststroke Cognitive Impairment: A Multicenter Prospective Study From CATIS.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Targeting Polyamine Metabolism in Colorectal Cancer: Apigenin Dismantles the HIF-1α/SMOX Positive Feedback Loop to Suppress Tumor Progression,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Spermidine improve high copper diet-induced intestinal oxidative stress and microbiota community composition.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Spermidine and spermine in elderly patients with coronary artery disease: a cross-sectional study of dietary intake and plasma and skeletal muscle concentrations.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effects of Spermidine-Rich Rice Germ Extract Supplement on Biomarkers of Healthy Aging and Autophagy-Proof-of-Concept Pilot Study.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Treatment of peri-implant mucositis using spermidine and calcium chloride as local adjunctive delivery to non-surgical mechanical debridement: a double-blind randomized controlled clinical trial.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Supplementation of spermidine at 40 mg/day has minimal effects on circulating polyamines: An exploratory double-blind randomized controlled trial in older men.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The role of spermidine in plants and humans: a pathway from climate change adaptation to health benefits,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Unraveling the role of polyamine metabolism in postoperative delirium: insights into biochemical mechanisms and biomarker potential,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Loss-of-function variant in spermidine/spermine N1-acetyl transferase like 1 ( SATL1 ) gene as an underlying cause of autism spectrum disorder,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Absorption, anti-inflammatory, antioxidant, and cardioprotective impacts of a novel fasting mimetic containing spermidine, nicotinamide, palmitoylethanolamide, and oleoylethanolamide: A pilot dose-escalation study in healthy young adult men.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
SPERMIDINE TOXICITY IN MITOCHONDRIAL DNA-DEFICIENT SACCHAROMYCES CEREVISIAE,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"The Effect of Foliar Application of Salicylic Acid, Spermidine and Sodium Nitroprusside on some Growth and Flowering Characteristics, Photosynthetic Pigments and Vase Life of Lisianthus ‘Mariachi Blue’",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Improving Vaccination in Older Adults by Inducing Autophagy With Spermidine,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Metabolic Responses to Spermidine Supplementation.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Polyamines in Food,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Consumption effect of a synbiotic beverage made from soy and yacon extracts containing Bifidobacterium animalis ssp. lactis BB-12 on the intestinal polyamine concentrations in elderly individuals.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Autophagy-Enhancers to Reduce Sleep Disturbances,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Bruno 2025,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Autophagy-Enhancers to Reduce Sleep n.d.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
SPERMIDINE TOXICITY in MITOCHONDRIAL 2022,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Improving Vaccination in Older 2023,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Metabolic Responses to Spermidine 2023,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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