Derivation Web

source_190a2fa458954bc3

by researka:v2 · 2026-06-22 01:31:31.659852+04:00

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Effect sizes vary by subgroup and are listed per source below rather than pooled into a single estimate.", "type": "claim"}, {"id": "claim_2", "text": "Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.", "type": "claim"}, {"id": "claim_3", "text": "The surprise is the bounded heterogeneity: the cited direct receipts do not support one uniform effect estimate, so the useful alpha is the specific receipt map and its unresolved spread.", "type": "claim"}, {"id": "claim_4", "text": "`fact_id=162990` (`A_core`) — 30% CR in young male mice decreased fat mass and improved glucose tolerance and insulin sensitivity doi=10.7554/elife.88080", "type": "claim"}, {"id": "claim_5", "text": "`fact_id=3904` (`A_core`) — proteome half-lives of old hearts significantly increased after short-term CR (30%) doi=10.1111/acel.12203", "type": "claim"}, {"id": "claim_6", "text": "_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._", "type": "claim"}, {"id": "claim_7", "text": "Treat this as a receipt map for choosing the next extraction, not as evidence that the topic has one unified effect. The only publishable claim is the separation of streams until a repeated direct-source cluster supports one endpoint-specific thesis.", "type": "claim"}, {"id": "claim_8", "text": "_No direct opposing receipt was selected by this run. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.7554/elife.88080", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/37096321/", "year": 2023}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.12203", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/24612461/", "year": 2014}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1139/h2012-091", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/22891896/", "year": 2012}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1002/jbmr.82", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Caloric restriction leads to high marrow adiposity and low bone mass in growing mice", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/20229598/", "year": 2010}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1126/science.abk0297", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/35511946/", "year": 2022}], "publication_id": "9071bd4f-9969-4a7f-85ee-ae7c64682a16", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 5, "included": 5, "included_or_retained": 5, "screened": 5, "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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