Derivation Web

source_1ac20481765a46b0

by researka:v2 · 2026-06-17 00:07:01.862336+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "e64257d3-7980-4e68-9b2d-12e06cf91b11", "sources": [{"directness": "review-level", "doi": "10.3390/nu18020238", "risk_of_bias": "not appraised in public sidecar", "study": "Metabolic and Orexin-A Responses to Ketogenic Diet and Intermittent Fasting: A 12-Month Randomized Trial in Adults with Obesity"}, {"directness": "review-level", "doi": "10.3390/nu18111799", "risk_of_bias": "not appraised in public sidecar", "study": "Age-Specific Analysis of the Effects of Intermittent Fasting on Body Composition and Cardiometabolic Markers in Healthy Adults and Individuals with Overweight or Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"}, {"directness": "review-level", "doi": "10.3389/fnut.2025.1664811", "risk_of_bias": "not appraised in public sidecar", "study": "Intermittent fasting improves metabolic outcomes in metabolic syndrome: a systematic review and meta-analysis with GRADE evaluation"}, {"directness": "primary", "doi": "10.1155/jnme/7185647", "risk_of_bias": "not appraised in public sidecar", "study": "Time‐Restricted Feeding Preserves Synaptic Function and Modulates Reelin and α ‐Synuclein in an Acute Amyloid‐ β Rat Model: A Comparative Study With Alternate‐Day Fasting"}, {"directness": "review-level", "doi": "10.3389/fnut.2026.1772836", "risk_of_bias": "not appraised in public sidecar", "study": "Optimal dosage of exercise combined with intermittent fasting for body composition and cardiometabolic health in adults: a systematic review and multilevel meta-analysis"}, {"directness": "review-level", "doi": "10.1186/s41043-025-00834-1", "risk_of_bias": "not appraised in public sidecar", "study": "The effectiveness of fasting regimens on serum levels of some major weight regulating hormones: a GRADE-assessed systematic review and meta-analysis in randomized controlled trial"}, {"directness": "primary", "doi": "10.3390/nu17091467", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Time-Restricted Fasting–Nicotinamide Mononucleotide Combination on Exercise Capacity via Mitochondrial Activation and Gut Microbiota Modulation"}, {"directness": "primary", "doi": "10.1096/fj.202503534R", "risk_of_bias": "not appraised in public sidecar", "study": "Intermittent Fasting Enhances Genome Integrity and Cytoprotective Pathways via (BHB) β‐Hydroxybutyrate Signaling and Chromatin Remodeling"}, {"directness": "primary", "doi": "10.7554/eLife.107332", "risk_of_bias": "not appraised in public sidecar", "study": "Uncovering shared and tissue-specific molecular adaptations to intermittent fasting in liver, brain, and muscle"}, {"directness": "primary", "doi": "10.1093/genetics/iyag045", "risk_of_bias": "not appraised in public sidecar", "study": "Genetic regulation of fasting-induced longevity effects"}, {"directness": "primary", "doi": "10.3390/nu18101608", "risk_of_bias": "not appraised in public sidecar", "study": "Simulation Effect and Mechanism of High-Polymeric Persimmon Tannin on Simulating Alternate-Day Fasting on Regulating Lipid Metabolism in Obese Mice"}, {"directness": "primary", "doi": "10.1111/acel.70052", "risk_of_bias": "not appraised in public sidecar", "study": "Alternate Day Fasting Enhances Intestinal Epithelial Function During Aging by Regulating Mitochondrial Metabolism"}, {"directness": "primary", "doi": "10.3390/biom15111514", "risk_of_bias": "not appraised in public sidecar", "study": "Adipose Inositol Monophosphate Metabolism Is Associated with Fasting Regimen-Elicited Metabolic Benefits"}, {"directness": "review-level", "doi": "10.3390/nu16162692", "risk_of_bias": "not appraised in public sidecar", "study": "Therapeutic Potential of Various Intermittent Fasting Regimens in Alleviating Type 2 Diabetes Mellitus and Prediabetes: A Narrative Review"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1001/jama.2010.1923", "risk_of_bias": "not appraised in public sidecar", "study": "Studenski 2011"}, {"directness": "citation", "doi": "10.1093/gerona/glp012", "risk_of_bias": "not appraised in public sidecar", "study": "Cesari 2009"}, {"directness": "citation", "doi": "10.1111/j.1532-5415.2006.00701.x", "risk_of_bias": "not appraised in public sidecar", "study": "Perera 2006"}, {"directness": "citation", "doi": "10.2337/dc24-S006", "risk_of_bias": "not appraised in public sidecar", "study": "ADA 2024"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "WHO 2000"}, {"directness": "citation", "doi": "10.1093/ageing/26.1.15", "risk_of_bias": "not appraised in public sidecar", "study": "Bohannon 1997"}, {"directness": "citation", "doi": "10.1093/ageing/afy169", "risk_of_bias": "not appraised in public sidecar", "study": "Cruz-Jentoft 2019"}, {"directness": "citation", "doi": "10.1056/NEJM198812293192604", "risk_of_bias": "not appraised in public sidecar", "study": "Tinetti 1988"}, {"directness": "citation", "doi": "10.1056/NEJMoa1504347", "risk_of_bias": "not appraised in public sidecar", "study": "Tancredi 2015"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "e64257d3-7980-4e68-9b2d-12e06cf91b11",
  "researka_submission_id": "7c5ccb76-8350-42ae-8ce7-2d6860416cf3",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/e64257d3-7980-4e68-9b2d-12e06cf91b11/sidecars/risk_of_bias.json"
}