Derivation Web

source_1ce69e319bca4045

by researka:v2 · 2026-06-12 09:16:40.081723+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"GLIMSI: A real-world, multicenter study assessing the effectiveness and safety of Sitagliptin + Glimepiride + Metformin FDC in Indian patients with Type 2 diabetes",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Efficacy and Safety of High-Dose Pioglitazone as Add-on Therapy in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Dapagliflozin and Metformin: Double-Blind, Randomized, Placebo-Controlled Trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
HRS-7535 for Type 2 Diabetes Inadequately Controlled With Metformin,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Efficacy and safety of combining empagliflozin in people with type 2 diabetes mellitus uncontrolled with metformin and sitagliptin: A randomised, double‐blind, multicentre, therapeutic confirmatory phase 3 clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Lobeglitazone improves glycaemic control as add‐on therapy to empagliflozin plus metformin in patients with type 2 diabetes mellitus: A double‐blind, randomised, placebo‐controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Triple oral therapy combining metformin, SGLT-2 and DPP-4 inhibitors versus dual therapy in type 2 diabetes mellitus: A systematic review and meta-analysis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Sitagliptin, Metformin and Glimepiride Fixed‐Dose Combination Compared to Co‐Administration of Metformin and High‐Dose Glimepiride in Indian Patients With Type 2 Diabetes: A Randomised, Double‐Blind, Double‐Dummy, Phase 3 Clinical Study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Efficacy and Safety of Fixed‐Dose Combinations of Sitagliptin and Empagliflozin as Add‐On to Metformin in Korean Patients With Type 2 Diabetes: A Randomised, Double‐Blind, Multi‐Centre, Placebo‐Controlled, Phase III Trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Efficacy and Safety of Glimepiride, Voglibose, and Metformin ER in Type 2 Diabetes: A Randomized, Active‐Controlled Study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Metformin attenuates metabolic insulin sensitivity and insulin‐stimulated carbohydrate oxidation after high‐intensity exercise training in adults at risk for metabolic syndrome,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Associations of modifiable preconception, pregnancy and postpartum factors with health outcomes for women with type 2 diabetes and their children: A systematic review and meta‐analysis of observational studies",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Glycaemic and Cardiometabolic Outcomes of Empagliflozin Versus Sitagliptin Added to Metformin in T2DM: Insights From a Systematic Review and Meta‐Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Impact of metformin on melanoma: a meta-analysis and systematic review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Effects of probiotic and metformin co-administration versus metformin monotherapy on anthropometric measurements, hormones, and glucolipid profile in women with polycystic ovary syndrome: a systematic review and meta-analysis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
EMERGE Mothers and Kids: a longitudinal cohort study of mothers and children enrolled in the randomized placebo-controlled trial of metformin in women with GDM (EMERGE): study protocol,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Association of preadmission metformin use and prognosis in patients with sepsis with diabetes: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effectiveness and safety of auricular therapy for polycystic ovary syndrome: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Metformin increases glycolysis and the stress-induced cytokine GDF15 but not FGF21 in humans,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Do We Have Enough Evidence That Metformin Is Superior to Other Antidiabetic Drugs in Pancreatic Cancer Risk Reduction?,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Dapagliflozin-induced integrated improvements in left ventricular diastole, endothelial function, and arterial load: a randomized clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Metformin for primary prevention of colorectal neoplasms in adenoma-free populations: a systematic review and dose-response meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Multi-strain probiotic reduces gastrointestinal side effects in women with elevated HOMA-IR index treated with metformin: a 12-week randomised controlled trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Efficacy and safety of traditional Chinese classic prescriptions combined with metformin in the treatment of type 2 diabetes mellitus: a Bayesian network meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
The role of male foetal sex on maternal and neonatal outcomes in pregnancies complicated by gestational diabetes—secondary analysis of a randomised placebo controlled clinical trial of metformin in gestational diabetes (EMERGE),not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effects of Premeal Versus Postmeal Metformin Administration on Postmeal Glycemic Control in Individuals With Type 2 Diabetes Mellitus: A Randomized, 8‐Week Crossover Study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Impact of Metformin on Vitamin B12 Levels in Children and Adolescents: A Systematic Review and Single‐Arm Meta‐Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Metformin safety during pregnancy in women with gestational diabetes mellitus: A systematic review and meta‐analysis of maternal, neonatal and long‐term outcomes",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
The Impact of Different Oral Antidiabetic Drugs on Insulin Pump Intensive Therapy in Type 2 Diabetes Patients: A Clinical Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effects of short‐term tofogliflozin treatment on the insulin secretory capacity of people with type 2 diabetes: A randomized controlled trial, the TOP ‐ ELM study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Optimising metformin use in polycystic ovary syndrome (MET-PCOS): study protocol for a double-blind randomised controlled trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"SGLT2 inhibitor or metformin as standard treatment in early‐stage type 2 diabetes? Baseline data in SMARTEST, a novel, decentralised, register‐based randomised trial on prevention of diabetic complications",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Bioequivalence assessment between two formulations of a film-coated fixed-dose combination of metformin and vildagliptin (850/50mg) in healthy Tunisian subjects under fed conditions,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Efficacy of metformin as an adjuvant therapy in gynecologic malignancies: a meta-analysis of randomized controlled trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Applying a hypothetical strategy to the intercurrent event of non-adherence with the parametric g-formula: a post hoc secondary analysis of the MET-PREVENT randomised controlled trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Time-Restricted Eating and Metformin in Invasive Breast Cancer or DCIS: A Randomized, Phase IIb, Presurgical Trial. Preliminary Safety Analysis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Metformin Use and Clinical Outcomes in Very Elderly Patients with Type 2 Diabetes and Chronic Kidney Disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The impact of antidiabetic drugs on dementia risk: a Bayesian network meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"MET-PREVENT: metformin to improve physical performance in older people with sarcopenia and physical prefrailty/frailty – protocol for a double-blind, randomised controlled proof-of-concept trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Disuse‐induced muscle fibrosis, cellular senescence, and senescence‐associated secretory phenotype in older adults are alleviated during re‐ambulation with metformin pre‐treatment",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Circulating Profiles of the Bile Acid Metabolomics in Patients With Polycystic Ovary Syndrome Treated With Metformin or Canagliflozin,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Paternal use of metformin and risk of major congenital malformations: A meta‐analysis of 4 studies,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effects of Ziziphus jujuba, metformin, and myoinositol on pregnancy rates and metabolic parameters in infertile women with PCOS: a randomized controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Metformin Downregulates the STAT Pathway and Reduces Bone Marrow Fibrosis in Primary Myelofibrosis Patients: Final Results of the Phase II FIBROMET Trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Efficacy and safety of adding a fourth oral antidiabetic drug versus metformin dose escalation in patients with type 2 diabetes inadequately controlled on triple oral combination therapy (EFFORT): A 24-week, randomized, open-label, multicenter trial.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Comparative Efficacy, Safety, and Cost‐Utility of DPP‐4 Inhibitors and Metformin Combination Therapy in Type 2 Diabetes: A Systematic Review of Real‐World Clinical and Economic Outcomes",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Metformin for asthma exacerbations,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Empagliflozin versus metformin for glucose variability and metabolic outcomes in drug-naïve type 2 diabetes: The EMPA-FIT study.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Randomized controlled trial of effects of metformin in NAFLD patients with newly diagnosed type 2 diabetes treated with an intensive lifestyle: a study protocol,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"The efficacy of metformin for pain, function, and quality of life in knee osteoarthritis: A systematic review and meta-analysis.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Metformin for knee osteoarthritis in overweight and obese adults: a systematic review and meta-analysis of efficacy, safety, and disease-modifying anti-inflammatory potential.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Pragmatic Trial of Metformin for Glucose Intolerance or Increased BMI in Prostate Cancer Patients,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"The Role of Antidiabetic Therapies in Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review of Metformin, Pioglitazone, and GLP-1 Receptor Agonists",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Association between preoperative metformin exposure and postoperative nausea and vomiting in patients undergoing general anaesthesia: a protocol for a prospective observational cohort study in a Chinese tertiary hospital,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effectiveness of metformin in the management of osteoarthritis in patients with type 2 diabetes.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
The mechanisms of action of metformin,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Metformin and the gastrointestinal tract,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
**Ioannidis 2005.** _Ioannidis JPA. Why most published research findings are false. PLoS Med. 2005;2(8):e124._ DOI: 10.1371/journal.pmed.0020124. PMID: 16060722.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
**ADA 2024.** _American Diabetes Association. Standards of Care in Diabetes. Diabetes Care. 2024;47(Suppl 1)._ DOI: 10.2337/dc24-S006.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Pragmatic 2035,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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