Derivation Web

source_1e343cd0ea064af5

by researka:v2 · 2026-06-25 13:08:48.770567+04:00

{"content_hash": null, "edges": [{"from": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "to": "claim_1", "type": "contains_claim"}, {"from": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "to": "claim_2", "type": "contains_claim"}, {"from": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "to": "claim_3", "type": "contains_claim"}, {"from": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "to": "claim_4", "type": "contains_claim"}, {"from": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "to": "claim_5", "type": "contains_claim"}, {"from": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "to": "claim_6", "type": "contains_claim"}, {"from": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "to": "claim_7", "type": "contains_claim"}, {"from": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "to": "claim_8", "type": "contains_claim"}, {"from": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "to": "claim_9", "type": "contains_claim"}, {"from": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "to": "claim_10", "type": "contains_claim"}], "nodes": [{"id": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "title": "fisetin: one bounded, context-dependent signal across receipts", "type": "publication"}, {"id": "claim_1", "text": "Across retrieved fact-level receipts for fisetin, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?", "type": "claim"}, {"id": "claim_2", "text": "Finding: DHC and fisetin caused dose-dependent reduction in viability and increase in apoptosis in PC3 cells at 72 h.", "type": "claim"}, {"id": "claim_3", "text": "This receipt-backed scoping note has one bounded signal: fisetin shows endpoint-specific favorable signals with context limits across this 5-source primary bundle (2010-2023). Grouped by direction: directionally favorable: 3 receipt(s) | other/mixed: 2 receipt(s). The source facts cover 5 population context(s) and 4 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. This is a heterogeneous indication/context map, not a unified disease-specific or endpoint-family claim. Concrete source-level examples: IC50 of fisetin 3.4 ± 0.3 μM on senescent cells versus 7.0 ± 0.4 μM on control cells; DHC and fisetin caused dose-dependent reduction in viability and increase in apoptosis in PC3 cells at 72 h; Only quercetin and fisetin inhibited DENV-2 and DENV-3 infection in the absence or presence of enhancing antibody (>90%, p<0.001);.", "type": "claim"}, {"id": "claim_4", "text": "null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.", "type": "claim"}, {"id": "claim_5", "text": "directionally favorable: Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells — DHC and fisetin caused dose-dependent reduction in viability and increase in apoptosis in PC3 cells at 72 h.", "type": "claim"}, {"id": "claim_6", "text": "directionally favorable: &lt;p&gt;Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies&lt;/p&gt; — Only quercetin and fisetin inhibited DENV-2 and DENV-3 infection in the absence or presence of enhancing antibody (>90%, p<0.001); ( mechanistic ablation supports the topic effect; not a comparator outcome)", "type": "claim"}, {"id": "claim_7", "text": "directionally favorable: Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models — Fisetin treatment significantly inhibited the activation of p38 and JNK, but had enhanced effect on ERK1/2. ( mechanistic ablation supports the topic effect; not a comparator outcome)", "type": "claim"}, {"id": "claim_8", "text": "Specific moderators in this bundle are population/indication (HEKa cells (adult human epidermal keratinocytes); Human U937-DC-SIGN macrophages infected with dengue virus serotypes 2 or 3; PC3 human prostate cancer cells; TNF-α stimulated NHEKs; senescent human umbilical vein endothelial cells (HUVECs)), study design/evidence type (primary).", "type": "claim"}, {"id": "claim_9", "text": "The selected receipts group because each carries a fact-level extraction for fisetin; they separate by context (human clinical/observational and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim.", "type": "claim"}, {"id": "claim_10", "text": "The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.14060", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "type": "source", "url": "https://doi.org/10.1111/acel.14060", "year": 2023}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1080/01635581003605524", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "type": "source", "url": "https://doi.org/10.1080/01635581003605524", "year": 2010}, {"comparator": "not extracted", "directness": "primary", "doi": "10.2147/idr.s210890", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "&lt;p&gt;Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies&lt;/p&gt;", "type": "source", "url": "https://doi.org/10.2147/idr.s210890", "year": 2019}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3389/fimmu.2022.1075804", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation", "type": "source", "url": "https://doi.org/10.3389/fimmu.2022.1075804", "year": 2023}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3390/cells8091089", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models", "type": "source", "url": "https://doi.org/10.3390/cells8091089", "year": 2019}], "publication_id": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 5, "included": 5, "included_or_retained": 5, "screened": 5, "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd",
  "researka_submission_id": "f7bfa17f-3070-45e1-be7d-998af175bac4",
  "sidecar_name": "claim_graph.json",
  "sidecar_url": "https://api.researka.org/publications/f7aceb24-5650-43e9-8e4f-c8d8c3a376dd/sidecars/claim_graph.json"
}