Derivation Web

source_230433634f584899

by researka:v2 · 2026-06-25 01:03:51.055549+04:00

{"content_hash": "sha256:60a2e77d33da10dc57c9619a294621ab6a4ec9ea7b6661d59fb4d8ce24bff832", "edges": [{"from": "25d06079-7430-4053-a3f7-8453bcb436ae", "to": "claim_1", "type": "contains_claim"}, {"from": "25d06079-7430-4053-a3f7-8453bcb436ae", "to": "claim_2", "type": "contains_claim"}, {"from": "25d06079-7430-4053-a3f7-8453bcb436ae", "to": "claim_3", "type": "contains_claim"}], "nodes": [{"id": "25d06079-7430-4053-a3f7-8453bcb436ae", "title": "OTC anti-inflammatories split muscle and tendon adaptation in older lifters", "type": "publication"}, {"id": "claim_1", "text": "Two 2010–2011 trial reports from the same cohort of 36 older adults (~64–67 yr) show that 12 weeks of knee extensor resistance training combined with daily OTC COX inhibitors did **not** blunt the expected adaptations — the direction of effect was the opposite of the prior in vitro and observational expectation embedded in each abstract. In Receipt 1 (10.1152/ajpregu.00611.2010), acetaminophen and ibuprofen *increased* muscle volume (~12.5% and ~10.9%) and strength (~19 kg gain) more than placebo; COX-1/-2 enzyme content was uninfluenced. Receipt 2 (10.1152/japplphysiol.01348.2010) shows patellar tendon cross-sectional area, deformation, stiffness, and modulus were largely *uninfluenced* by ibuprofen, while acetaminophen moved tendon mechanics toward greater deformation/lower stiffness.", "type": "claim"}, {"id": "claim_2", "text": "A coupled boundary condition: the **muscle** signal is positive (drugs *amplified* volume/strength gains, the inversion of the \"COX inhibitors blunt adaptation\" hypothesis), while the **tendon** signal is split — ibuprofen ≈ null on tendon mechanics, acetaminophen pulls tendon properties in a *negative* direction (–17% stiffness, –20% modulus). The non-obvious bridge is that the same molecule behaves as an anabolic-adjacent signal for muscle and as a compliance-reducing signal for the tendon it must pull against, raising a muscle–tendon mismatch that is invisible if only muscle endpoints are read.", "type": "claim"}, {"id": "claim_3", "text": "For any \"longevity + resistance training\" product, supplement, or programming stack aimed at sarcopenia reversal in adults ~64–67 yr, the receipts frame a testable counter-hypothesis: concomitant OTC analgesic use is not a default negative for muscle outcomes, but the tendon side may be the binding constraint on safe force transfer. A 30- to 36-person, 12-week, double-blind, placebo-controlled setting is the kind of evidence that procurement, coaching apps, and senior-fitness brands may be importing or ignoring without distinguishing muscle from tendon endpoints.", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1152/ajpregu.00611.2010", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1152/japplphysiol.01348.2010", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Influence of acetaminophen and ibuprofen on patellar tendon adaptations to knee extensor resistance exercise in older adults", "type": "source", "url": null, "year": null}], "publication_id": "25d06079-7430-4053-a3f7-8453bcb436ae", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 2, "included": 2, "included_or_retained": 2, "screened": 2, "wording": "2 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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