Derivation Web

source_275870f6cb3a4fa1

by researka:v2 · 2026-06-20 00:34:54.318212+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "08943c0f-97ab-41e2-820b-bf2dbe384513", "sources": [{"directness": "review-level", "doi": "10.1186/s40360-023-00706-6", "risk_of_bias": "not appraised in public sidecar", "study": "The effect of acarbose on lipid profiles in adults: a systematic review and meta-analysis of randomized clinical trials"}, {"directness": "primary", "doi": "10.1038/s41598-021-84015-0", "risk_of_bias": "not appraised in public sidecar", "study": "The effects of acarbose therapy on reductions of myocardial infarction and all-cause death in T2DM during 10-year multifactorial interventions (The Beijing Community Diabetes Study 24)"}, {"directness": "review-level", "doi": "10.1111/dom.14661", "risk_of_bias": "not appraised in public sidecar", "study": "Efficacy and safety of alogliptin versus acarbose in Chinese type 2 diabetes patients with high cardiovascular risk or coronary heart disease treated with aspirin and inadequately controlled with metformin monotherapy or drug‐naive: A multicentre, randomized, open‐label, prospective study ( ACADEMIC"}, {"directness": "primary", "doi": "10.2147/DMSO.S325683", "risk_of_bias": "not appraised in public sidecar", "study": "Acarbose Reduces Low-Grade Albuminuria Compared to Metformin in Chinese Patients with Newly Diagnosed Type 2 Diabetes"}, {"directness": "primary", "doi": "10.1002/oby.24369", "risk_of_bias": "not appraised in public sidecar", "study": "The Supportive Effect of Acarbose to Orlistat in Weight Management—A Randomized, Double‐Blind, Multiarm Phase 2 Trial"}, {"directness": "primary", "doi": "10.3389/fendo.2025.1575087", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of acarbose and vildagliptin on plasma trimethylamine N-oxide levels in patients with type 2 diabetes mellitus: a 6-month, two-arm randomized controlled trial"}, {"directness": "review-level", "doi": "10.3389/fendo.2020.00288", "risk_of_bias": "not appraised in public sidecar", "study": "Acarbose With Comparable Glucose-Lowering but Superior Weight-Loss Efficacy to Dipeptidyl Peptidase-4 Inhibitors: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials"}, {"directness": "primary", "doi": "10.1002/cpdd.921", "risk_of_bias": "not appraised in public sidecar", "study": "Evaluation of the Bioequivalence of Acarbose in Healthy Chinese People"}, {"directness": "primary", "doi": "10.1111/dom.70611", "risk_of_bias": "not appraised in public sidecar", "study": "Acarbose or Canagliflozin vs. Placebo to Ameliorate Post‐Bariatric Hypoglycaemia: The Clinical Outcomes of the HypoBar I Randomised Clinical Trial"}, {"directness": "primary", "doi": "10.1177/0300060520960317", "risk_of_bias": "not appraised in public sidecar", "study": "Method for evaluating the human bioequivalence of acarbose based on pharmacodynamic parameters"}, {"directness": "review-level", "doi": "10.3389/fcvm.2021.663635", "risk_of_bias": "not appraised in public sidecar", "study": "Acarbose for Postprandial Hypotension With Glucose Metabolism Disorders: A Systematic Review and Meta-Analysis"}, {"directness": "review-level", "doi": "10.1017/s0714980825100056", "risk_of_bias": "not appraised in public sidecar", "study": "The Effects of Acarbose on the Postprandial Hypotensive Response in Older Adults."}, {"directness": "review-level", "doi": "10.1101/2025.08.25.671822", "risk_of_bias": "not appraised in public sidecar", "study": "The gerotherapeutic drugs rapamycin, acarbose, and phenylbutyrate extend lifespan and enhance healthy aging in house crickets"}, {"directness": "review-level", "doi": "10.1007/s12325-020-01602-9", "risk_of_bias": "not appraised in public sidecar", "study": "The Effects of Acarbose on Non-Diabetic Overweight and Obese Patients: A Meta-Analysis."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1001/jama.2010.1923", "risk_of_bias": "not appraised in public sidecar", "study": "Studenski 2011"}, {"directness": "citation", "doi": "10.1093/gerona/glp012", "risk_of_bias": "not appraised in public sidecar", "study": "Cesari 2009"}, {"directness": "citation", "doi": "10.1111/j.1532-5415.2006.00701.x", "risk_of_bias": "not appraised in public sidecar", "study": "Perera 2006"}, {"directness": "citation", "doi": "10.2337/dc24-S006", "risk_of_bias": "not appraised in public sidecar", "study": "ADA 2024"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "WHO 2000"}, {"directness": "citation", "doi": "10.1093/ageing/26.1.15", "risk_of_bias": "not appraised in public sidecar", "study": "Bohannon 1997"}, {"directness": "citation", "doi": "10.1093/ageing/afy169", "risk_of_bias": "not appraised in public sidecar", "study": "Cruz-Jentoft 2019"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "Anisimov 2008"}, {"directness": "citation", "doi": "10.1056/NEJMoa1504347", "risk_of_bias": "not appraised in public sidecar", "study": "Tancredi 2015"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "08943c0f-97ab-41e2-820b-bf2dbe384513",
  "researka_submission_id": "c692a542-ec48-4973-8fc0-452c722f7c5d",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/08943c0f-97ab-41e2-820b-bf2dbe384513/sidecars/risk_of_bias.json"
}