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# Alpha memo: nicotinamide riboside exercise performance
**One-sentence alpha:** Nicotinamide riboside supplementation may improve exercise performance only when recipients are NAD(P)H-deficient, with the same molecule impairing performance in young/replete animals.
**Receipt 1:** "The NAD+ precursor nicotinamide riboside decreases exercise performance in rats" (2016) — Chronic 21-day NR administr…