Derivation Web

source_2c12e7f03d2f460b

by researka:v2 · 2026-06-24 19:38:07.768674+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effect of Young Plasma Therapy on Cognition, Oxidative Stress, miRNA-134, BDNF, CREB, and SIRT-1 Expressions and Neuronal Survey in the Hippocampus of Aged Ovariectomized Rats with Alzheimer’s",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Young blood plasma reduces Alzheimer’s disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The rejuvenating influence of young plasma on aged intestine,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Young plasma reverses anesthesia and surgery-induced cognitive impairment in aged rats by modulating hippocampal synaptic plasticity,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Therapeutic potential of young plasma in reversing age-related liver inflammation via modulation of NLRP3 inflammasome and necroptosis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Chronic stress-induced anxiety-like behavior, hippocampal oxidative, and endoplasmic reticulum stress are reversed by young plasma transfusion in aged adult rats",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Rejuvenating the gut: young plasma therapy improves cell proliferation, IGF-I and IGF-IR expression, and immune defense in aged male rats jejunum",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Young Plasma Attenuated Chronic Kidney Disease Progression after Acute Kidney Injury by Inhibiting Inflammation in Mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Young plasma attenuates cognitive impairment and the cortical hemorrhage area in cerebral amyloid angiopathy model mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Young Plasma Rejuvenates Blood DNA Methylation Profile, Extends Mean Lifespan, and Improves Physical Appearance in Old Rats",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Safety of Plasma Infusions in Parkinson's Disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A simple cell proliferation assay and the inflammatory protein content show significant differences in human plasmas from young and old subjects,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Exosomes from young plasma stimulate the osteogenic differentiation and prevent osteoporosis via miR-142-5p,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Young plasma transfer enhances antioxidant defense and preserves structural integrity in aged lung tissue.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Young plasma ameliorates aging-related acute brain injury after intracerebral hemorrhage,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Young plasma reverses age‐dependent alterations in hepatic function through the restoration of autophagy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Perera 2006,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Bohannon 1997,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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