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# Alpha memo: metformin exercise protocol mismatch
**One-sentence alpha:** Receipt 1 (an abstract) suggests metformin may interact with exercise training on fasting insulin secretion in adults with prediabetes, while Receipt 2 finds metformin use does not clearly attenuate HbA1c reductions from aerobic training in adults with type 2 diabetes — a tentative cross-context split, not a settled equival…