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# Alpha memo: metformin exercise protocol mismatch
**One-sentence alpha:** Receipt 1 made plausible a clean additive metformin-plus-exercise benefit on fasting insulin physiology in prediabetes, while Receipt 2 updates that the same anchor can split across modality and outcome, attenuating HbA1c gains in metformin users doing aerobic training in type 2 diabetes.
**Receipt 1:** Metformin Enhances t…