Derivation Web

source_2f904a5d566c4874

by researka:v2 · 2026-06-02 12:09:30.791017+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "bd4ddec9-e10e-445f-bf0b-a5399dfae223", "sources": [{"directness": "primary", "doi": "10.1093/ecco-jcc/jjad049", "risk_of_bias": "not appraised in public sidecar", "study": "Jongsma 2023"}, {"directness": "primary", "doi": "10.1038/s41392-025-02252-5", "risk_of_bias": "not appraised in public sidecar", "study": "Xie 2025"}, {"directness": "primary", "doi": "10.3389/fimmu.2024.1413956", "risk_of_bias": "not appraised in public sidecar", "study": "Wallen 2024"}, {"directness": "primary", "doi": "10.1038/s44319-025-00516-3", "risk_of_bias": "not appraised in public sidecar", "study": "Hoang 2025"}, {"directness": "primary", "doi": "10.1016/j.ekir.2025.103766", "risk_of_bias": "not appraised in public sidecar", "study": "Boudhabhay 2026"}, {"directness": "primary", "doi": "10.1016/j.heliyon.2024.e31910", "risk_of_bias": "not appraised in public sidecar", "study": "Nakanjako 2024"}, {"directness": "primary", "doi": "10.3389/fimmu.2025.1523871", "risk_of_bias": "not appraised in public sidecar", "study": "Ledee 2025"}, {"directness": "primary", "doi": "10.1111/acel.14460", "risk_of_bias": "not appraised in public sidecar", "study": "Fang 2025"}, {"directness": "primary", "doi": "10.1186/s12943-024-01970-8", "risk_of_bias": "not appraised in public sidecar", "study": "Levy 2024"}, {"directness": "primary", "doi": "10.1038/s41598-025-04736-4", "risk_of_bias": "not appraised in public sidecar", "study": "Davies 2025"}, {"directness": "primary", "doi": "10.3389/fimmu.2025.1623319", "risk_of_bias": "not appraised in public sidecar", "study": "Qiao 2025"}, {"directness": "primary", "doi": "10.3389/fnut.2024.1474597", "risk_of_bias": "not appraised in public sidecar", "study": "Perlmutter 2024"}, {"directness": "primary", "doi": "10.1016/j.ebiom.2022.104179", "risk_of_bias": "not appraised in public sidecar", "study": "Zuroff 2022"}, {"directness": "primary", "doi": "10.1016/j.bbih.2025.100993", "risk_of_bias": "not appraised in public sidecar", "study": "Rob 2025"}, {"directness": "primary", "doi": "10.1158/1078-0432.CCR-23-0229", "risk_of_bias": "not appraised in public sidecar", "study": "Nawrocki 2023"}, {"directness": "primary", "doi": "10.1186/s42523-024-00318-3", "risk_of_bias": "not appraised in public sidecar", "study": "Stark 2024"}, {"directness": "primary", "doi": "10.1111/acel.70050", "risk_of_bias": "not appraised in public sidecar", "study": "Liu 2025"}, {"directness": "primary", "doi": "10.1038/s41398-026-04037-y", "risk_of_bias": "not appraised in public sidecar", "study": "Arjmand 2026"}, {"directness": "primary", "doi": "10.3389/fragi.2025.1716985", "risk_of_bias": "not appraised in public sidecar", "study": "Trebing 2025"}, {"directness": "primary", "doi": "10.3390/biology11111576", "risk_of_bias": "not appraised in public sidecar", "study": "Brode 2022"}, {"directness": "primary", "doi": "10.1038/s43587-025-00819-z", "risk_of_bias": "not appraised in public sidecar", "study": "Li 2025"}, {"directness": "primary", "doi": "10.1111/acel.13792", "risk_of_bias": "not appraised in public sidecar", "study": "Karakaslar 2023"}, {"directness": "primary", "doi": "10.1111/acel.13702", "risk_of_bias": "not appraised in public sidecar", "study": "Shin 2022"}, {"directness": "primary", "doi": "10.3390/biom16010055", "risk_of_bias": "not appraised in public sidecar", "study": "Brode 2025"}, {"directness": "primary", "doi": "10.1007/s00277-023-05603-w", "risk_of_bias": "not appraised in public sidecar", "study": "Qing 2024"}, {"directness": "primary", "doi": "10.3389/fimmu.2026.1742646", "risk_of_bias": "not appraised in public sidecar", "study": "Ma 2026"}, {"directness": "primary", "doi": "10.1097/CCE.0000000000001106", "risk_of_bias": "not appraised in public sidecar", "study": "Samuelsen 2024"}, {"directness": "primary", "doi": "10.1038/s41390-022-02203-8", "risk_of_bias": "not appraised in public sidecar", "study": "Qu 2022"}, {"directness": "primary", "doi": "10.1038/s41467-024-52522-z", "risk_of_bias": "not appraised in public sidecar", "study": "Hu 2024"}, {"directness": "primary", "doi": "10.1186/s12979-024-00490-9", "risk_of_bias": "not appraised in public sidecar", "study": "Govind 2024"}, {"directness": "primary", "doi": "10.7554/eLife.86136", "risk_of_bias": "not appraised in public sidecar", "study": "Roy 2023"}, {"directness": "primary", "doi": "10.3390/ijms241713186", "risk_of_bias": "not appraised in public sidecar", "study": "Brode 2023"}, {"directness": "primary", "doi": "10.1097/HEP.0000000000000590", "risk_of_bias": "not appraised in public sidecar", "study": "Liu 2023"}, {"directness": "primary", "doi": "10.3390/cells14221793", "risk_of_bias": "not appraised in public sidecar", "study": "Le 2025"}, {"directness": "primary", "doi": "10.1097/CCM.0000000000005832", "risk_of_bias": "not appraised in public sidecar", "study": "Peronnet 2023"}, {"directness": "primary", "doi": "10.1093/geroni/igaf122.2016", "risk_of_bias": "not appraised in public sidecar", "study": "Noppert 2025"}, {"directness": "primary", "doi": "10.1186/s12929-025-01146-6", "risk_of_bias": "not appraised in public sidecar", "study": "Rousseau 2025"}, {"directness": "primary", "doi": "10.3389/frtra.2024.1356948", "risk_of_bias": "not appraised in public sidecar", "study": "Kapse 2024"}, {"directness": "primary", "doi": "10.1093/geroni/igad104.1007", "risk_of_bias": "not appraised in public sidecar", "study": "Noppert 2023"}, {"directness": "primary", "doi": "10.3390/ijms27031206", "risk_of_bias": "not appraised in public sidecar", "study": "Aitella 2026"}, {"directness": "primary", "doi": "10.1136/jitc-2025-012432", "risk_of_bias": "not appraised in public sidecar", "study": "Zhang 2025"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "bd4ddec9-e10e-445f-bf0b-a5399dfae223",
  "researka_submission_id": "042b0fa6-e34a-40b6-be77-f50702011d32",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/bd4ddec9-e10e-445f-bf0b-a5399dfae223/sidecars/risk_of_bias.json"
}