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source_300af31c5ed14e91

sha256 1c8135938c9b6d9cdfd11e98db106af5261f99a669025d74b60ca9f78b959564

by researka:v2 · 2026-06-07 09:05:04.941534+04:00

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"not appraised in public sidecar", "study": "Rapamycin-modified novel tolerogenic dendritic cells induce liver graft tolerance through MHC-II + CD8 + regulatory T cells"}, {"directness": "primary", "doi": "10.1038/s43856-025-00904-9", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin treatment for Alzheimer’s disease and related dementias: a pilot phase 1 clinical trial"}, {"directness": "primary", "doi": "10.3390/neurosci7030055", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin and Minocycline Treatment Does Not Rescue Behavioral and Molecular Changes Induced by Early-Life Seizures in Female Mice"}, {"directness": "primary", "doi": "10.1016/j.redox.2025.103970", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin preserves cardiac function in autoimmune myocarditis by reprogramming Cxcl9 + macrophages via the mTORC1–C/EBPβ–OSM axis"}, {"directness": "primary", "doi": "10.18632/aging.206300", "risk_of_bias": "not appraised in public sidecar", "study": "What is the clinical evidence to support off-label rapamycin therapy in healthy adults?"}, {"directness": "primary", "doi": "10.3390/microorganisms14040781", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin Prevents Sulfate-Reducing Bacteria-Induced Effects on Snail and GSK-3 and Impaired Intestinal Barrier"}, {"directness": "primary", "doi": "10.1186/s12967-025-07213-8", "risk_of_bias": "not appraised in public sidecar", "study": "Low-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study"}, {"directness": "primary", "doi": "10.1126/sciadv.aec5134", "risk_of_bias": "not appraised in public sidecar", "study": "Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism"}, {"directness": "review-level", "doi": "10.1186/s13063-024-08490-2", "risk_of_bias": "not appraised in public sidecar", "study": "A single-center, double-blind, randomized, placebo-controlled, two-arm study to evaluate the safety and efficacy of once-weekly sirolimus (rapamycin) on muscle strength and endurance in older adults following a 13-week exercise program"}, {"directness": "primary", "doi": "10.1371/journal.pone.0343183", "risk_of_bias": "not appraised in public sidecar", "study": "Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging"}, {"directness": "primary", "doi": "10.20517/cdr.2025.35", "risk_of_bias": "not appraised in public sidecar", "study": "Unveiling MAGEA3: a novel predictive biomarker for bevacizumab resistance in colorectal cancer"}, {"directness": "primary", "doi": "10.1093/jacamr/dlag091", "risk_of_bias": "not appraised in public sidecar", "study": "Fpr1p mediates the synergistic effect of rapamycin or tacrolimus with caspofungin in Clavispora lusitaniae in vitro"}, {"directness": "primary", "doi": "10.1038/s12276-025-01578-y", "risk_of_bias": "not appraised in public sidecar", "study": "RPS24 microexon isoform as a novel biomarker for estrogen receptor-positive breast cancer progression and therapeutic resistance"}, {"directness": "primary", "doi": "10.3389/fragi.2025.1628187", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin for longevity: the pros, the cons, and future perspectives"}, {"directness": "primary", "doi": "10.3389/fonc.2021.608570", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin Antagonizes BCRP-Mediated Drug Resistance Through the PI3K/Akt/mTOR Signaling Pathway in mPRα-Positive Breast Cancer"}, {"directness": "primary", "doi": "10.7554/eLife.16351", "risk_of_bias": "not appraised in public sidecar", "study": "Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice"}, {"directness": "primary", "doi": "10.2337/db14-1132", "risk_of_bias": "not appraised in public sidecar", "study": "Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms"}, {"directness": "primary", "doi": "10.1111/acel.12203", "risk_of_bias": "not appraised in public sidecar", "study": "Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart"}, {"directness": "primary", "doi": "10.1111/acel.12194", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction"}, {"directness": "primary", "doi": "10.1155/2017/2976541", "risk_of_bias": "not appraised in public sidecar", "study": "Rapid Rapamycin-Only Induced Osteogenic Differentiation of Blood-Derived Stem Cells and Their Adhesion to Natural and Artificial Scaffolds"}, {"directness": "primary", "doi": "10.1111/acel.12587", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism"}, {"directness": "primary", "doi": "10.1016/j.cmet.2009.11.010", "risk_of_bias": "not appraised in public sidecar", "study": "Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster"}, {"directness": "primary", "doi": "10.1038/nature08221", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin fed late in life extends lifespan in genetically heterogeneous mice"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}
metadata
{
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  "sidecar_url": "https://api.researka.org/publications/b3041d87-87dd-46e9-a8ea-5a13c317c885/sidecars/risk_of_bias.json"
}

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