Derivation Web

source_30d389b7065a453a

by researka:v2 · 2026-06-16 16:15:11.805339+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "ad6bd204-1859-4516-b412-8f3a7f40f350", "sources": [{"directness": "primary", "doi": "10.1186/s12979-024-00487-4", "risk_of_bias": "not appraised in public sidecar", "study": "CD57 + EMRA CD8 + T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy"}, {"directness": "primary", "doi": "10.1007/s11357-022-00685-2", "risk_of_bias": "not appraised in public sidecar", "study": "Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study"}, {"directness": "primary", "doi": "10.1186/s12967-024-05814-3", "risk_of_bias": "not appraised in public sidecar", "study": "Clinical outcomes of autologous adipose-derived mesenchymal stem cell combined with high tibial osteotomy for knee osteoarthritis are correlated with stem cell stemness and senescence"}, {"directness": "primary", "doi": "10.3389/fimmu.2025.1566227", "risk_of_bias": "not appraised in public sidecar", "study": "A bibliometric and visual analysis of the impact of senescence on tumor immunotherapy"}, {"directness": "primary", "doi": "10.3390/ijms27104406", "risk_of_bias": "not appraised in public sidecar", "study": "Exploratory Effects of a Novel Nutraceutical on Senescence-Related Protein Biomarkers in Healthy Adults: A Pilot Proteomics Study"}, {"directness": "primary", "doi": "10.1111/dme.70059", "risk_of_bias": "not appraised in public sidecar", "study": "The cardio‐renal‐metabolic role of the nod‐like receptor protein‐3 and senescence‐associated secretory phenotype in early sodium/glucose cotransporter‐2 inhibitor therapy in people with diabetes who have had a myocardial infarction"}, {"directness": "primary", "doi": "10.3390/cancers18111710", "risk_of_bias": "not appraised in public sidecar", "study": "Attenuation of Immune Senescence Markers After Intensive Cancer Therapy Through Resistance Training: A Pilot Study"}, {"directness": "primary", "doi": "10.3389/fendo.2023.1255889", "risk_of_bias": "not appraised in public sidecar", "study": "Using proteomics and metabolomics to identify therapeutic targets for senescence mediated cancer: genetic complementarity method"}, {"directness": "review-level", "doi": "10.3390/biomedicines14040875", "risk_of_bias": "not appraised in public sidecar", "study": "Exercise, Cellular Senescence, and Cancer: Novel Perspectives on Functional Aging Through Block Strength Training in Older Adults—A Narrative Review"}, {"directness": "review-level", "doi": "10.3390/ijms27031520", "risk_of_bias": "not appraised in public sidecar", "study": "Histological and Genetic Markers of Cellular Senescence in Keratinocyte Cancers and Actinic Keratosis: A Systematic Review"}, {"directness": "primary", "doi": "10.1186/s12935-021-02358-0", "risk_of_bias": "not appraised in public sidecar", "study": "Identification and validation of cellular senescence patterns to predict clinical outcomes and immunotherapeutic responses in lung adenocarcinoma"}, {"directness": "review-level", "doi": "10.64898/2026.01.06.697856", "risk_of_bias": "not appraised in public sidecar", "study": "Targeting the senescence-associated immune checkpoint GD3 ganglioside extends healthspan and blunt age-related diseases with sex-specific benefits"}, {"directness": "primary", "doi": "10.3389/fgene.2024.1461404", "risk_of_bias": "not appraised in public sidecar", "study": "Non-coding RNAs participate in interactions between senescence and gastrointestinal cancers"}, {"directness": "review-level", "doi": "10.1001/jama.2010.1923", "risk_of_bias": "not appraised in public sidecar", "study": "**Studenski 2011.** _Studenski S, Perera S, Patel K, et al. Gait speed and survival in older adults. JAMA. 2011;305(1):50-58._ DOI: 10.1001/jama.2010.1923. PMID: 21205966."}, {"directness": "review-level", "doi": "10.1093/ageing/afy169", "risk_of_bias": "not appraised in public sidecar", "study": "**Cruz-Jentoft 2019.** _Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31._ DOI: 10.1093/ageing/afy169. PMID: 30312372."}, {"directness": "review-level", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "**Ioannidis 2005.** _Ioannidis JPA. Why most published research findings are false. PLoS Med. 2005;2(8):e124._ (methodological reference) DOI: 10.1371/journal.pmed.0020124. PMID: 16060722."}, {"directness": "review-level", "doi": "10.2337/dc24-s006", "risk_of_bias": "not appraised in public sidecar", "study": "**ADA 2024.** _American Diabetes Association. Standards of Care in Diabetes. Diabetes Care. 2024;47(Suppl 1)._ DOI: 10.2337/dc24-S006."}, {"directness": "review-level", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Owen 2000.** _Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J. 2000;348 Pt 3:607-614._ PMID: 10839993."}, {"directness": "review-level", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Anisimov 2008.** _Anisimov VN, Berstein LM, Egormin PA, et al. Metformin slows down aging and extends life span of female SHR mice. Cell Cycle. 2008;7(17):2769-2773._ PMID: 18728386."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}]}

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}