Derivation Web

source_344272404e114010

by researka:v2 · 2026-06-21 20:56:16.432935+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
The NAD-brain pharmacokinetic study of NAD augmentation in blood and brain using oral precursor supplementation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"NAD + -Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients: a randomised, double-blinded, placebo-controlled phase-II trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Oral MIB‐626 (β Nicotinamide Mononucleotide) Safely Raises Blood Nicotinamide Adenine Dinucleotide Levels in Hospitalized Patients With COVID‐19 and Acute Kidney Injury: A Randomized Controlled Trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Nicotinamide riboside and caffeine partially restore diminished NAD availability but not altered energy metabolism in Alzheimer's disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Nicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The differential impact of three different NAD + boosters on circulatory NAD and microbial metabolism in humans,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Double‐Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Trigonelline is an NAD + precursor that improves muscle function during ageing and is reduced in human sarcopenia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
NAD + and Sirt5 restore mitochondrial bioenergetics failure and improve locomotor defects caused by sucla2 mutations,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Maternal Circulatory NAD Precursor Levels and the Yolk Sac Determine NAD Deficiency‐Driven Congenital Malformation Risk,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Mitochondrial Resilience in Glaucoma: Targeting NAD + Metabolism and Oxidative Stress in Retinal Ganglion Cell Degeneration with Nicotinamide Riboside and Berberine: Preliminary Clinical Evidence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
NAD + Enhancer Nicotinamide Riboside Alters Extracellular Purine Metabolism in Human Endothelial Cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
From Bench to Clinic: The 2024 FASEB Scientific Research Conference on NAD Metabolism and Signaling,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD + Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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