Derivation Web

source_35d4d2bb123e49d4

by researka:v2 · 2026-06-16 16:15:11.776439+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
CD57 + EMRA CD8 + T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Clinical outcomes of autologous adipose-derived mesenchymal stem cell combined with high tibial osteotomy for knee osteoarthritis are correlated with stem cell stemness and senescence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A bibliometric and visual analysis of the impact of senescence on tumor immunotherapy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Exploratory Effects of a Novel Nutraceutical on Senescence-Related Protein Biomarkers in Healthy Adults: A Pilot Proteomics Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The cardio‐renal‐metabolic role of the nod‐like receptor protein‐3 and senescence‐associated secretory phenotype in early sodium/glucose cotransporter‐2 inhibitor therapy in people with diabetes who have had a myocardial infarction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Attenuation of Immune Senescence Markers After Intensive Cancer Therapy Through Resistance Training: A Pilot Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Using proteomics and metabolomics to identify therapeutic targets for senescence mediated cancer: genetic complementarity method,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Exercise, Cellular Senescence, and Cancer: Novel Perspectives on Functional Aging Through Block Strength Training in Older Adults—A Narrative Review",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Histological and Genetic Markers of Cellular Senescence in Keratinocyte Cancers and Actinic Keratosis: A Systematic Review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Identification and validation of cellular senescence patterns to predict clinical outcomes and immunotherapeutic responses in lung adenocarcinoma,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Targeting the senescence-associated immune checkpoint GD3 ganglioside extends healthspan and blunt age-related diseases with sex-specific benefits,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Non-coding RNAs participate in interactions between senescence and gastrointestinal cancers,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Studenski 2011.** _Studenski S, Perera S, Patel K, et al. Gait speed and survival in older adults. JAMA. 2011;305(1):50-58._ DOI: 10.1001/jama.2010.1923. PMID: 21205966.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Cruz-Jentoft 2019.** _Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31._ DOI: 10.1093/ageing/afy169. PMID: 30312372.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
**Ioannidis 2005.** _Ioannidis JPA. Why most published research findings are false. PLoS Med. 2005;2(8):e124._ (methodological reference) DOI: 10.1371/journal.pmed.0020124. PMID: 16060722.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
**ADA 2024.** _American Diabetes Association. Standards of Care in Diabetes. Diabetes Care. 2024;47(Suppl 1)._ DOI: 10.2337/dc24-S006.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Owen 2000.** _Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J. 2000;348 Pt 3:607-614._ PMID: 10839993.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Anisimov 2008.** _Anisimov VN, Berstein LM, Egormin PA, et al. Metformin slows down aging and extends life span of female SHR mice. Cell Cycle. 2008;7(17):2769-2773._ PMID: 18728386.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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