Derivation Web

source_36254b7214af450f

by researka:v2 · 2026-06-26 03:53:41.683658+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Quercetin Reduces Vascular Senescence and Inflammation in Symptomatic Male but Not Female Coronary Artery Disease Patients,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Identification of Peptides from Edible Pleurotus eryngii Mushroom Feet and the Effect of Delaying D-Galactose-Induced Senescence of PC12 Cells Through TLR4/NF-κB/MAPK Signaling Pathways,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Age-related exacerbation of hematopoietic organ damage induced by systemic hyper-inflammation in senescence-accelerated mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
ADSC-enriched adipose extract alleviates cartilage fibrosis in temporomandibular joint osteoarthritis by inhibiting chondrocyte senescence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults—A Pilot Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Use of Nutraceuticals in Elderly to Fight Inflammation and Immuno-Senescence: A Randomized Case-Control Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Clinical outcomes of autologous adipose-derived mesenchymal stem cell combined with high tibial osteotomy for knee osteoarthritis are correlated with stem cell stemness and senescence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Distinct effects of rosuvastatin and rosuvastatin/ezetimibe on senescence markers of CD8+ T cells in patients with type 2 diabetes mellitus: a randomized controlled trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
LncRNA Gm44981 modulates EZH2–H3K27me3–p21 axis to suppress mesangial cell senescence and kidney aging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effect of menopausal hormone therapy on proteins associated with senescence and inflammation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Evidence gaps in the effects of exercise on SASP-Related biomarkers in older adults: a systematic review and meta-analysis of randomized controlled trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Association of Molecular Senescence Markers in Late-Life Depression With Clinical Characteristics and Treatment Outcome,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A proteomic atlas of senescence-associated secretomes for aging biomarker development,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
PPARγ attenuates cellular senescence of alveolar macrophages in asthma-COPD overlap,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
TPR is required for cytoplasmic chromatin fragment formation during senescence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
In Vitro Models of Cell Senescence: A Systematic Review on Musculoskeletal Tissues and Cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Life span, growth, senescence and island syndrome: Accounting for imperfect detection and continuous growth",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Tranexamic acid protects human dermal fibroblasts from D-galactose-induced senescence via the GPR30/MAPK pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Circulating Inflammatory, Mitochondrial Dysfunction, and Senescence-Related Markers in Older Adults with Physical Frailty and Sarcopenia: A BIOSPHERE Exploratory Study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Dermal cellular senescence and EndMT in patients with systemic sclerosis undergoing cyclophosphamide or aHSCT treatment,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Exploratory Effects of a Novel Nutraceutical on Senescence-Related Protein Biomarkers in Healthy Adults: A Pilot Proteomics Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Disuse‐induced muscle fibrosis, cellular senescence, and senescence‐associated secretory phenotype in older adults are alleviated during re‐ambulation with metformin pre‐treatment",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Regenerative potential of Dental Pulp Stem Cells (DPSCs) in dental and periodontal tissue engineering: a systematic review of preclinical and clinical studies,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Low-level HIV-1 viremia affects T-cell activation and senescence in long-term treated adults in the INSTI era,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Moderate-vigorous physical activity attenuates premature senescence of immune cells in sedentary adults with obesity: a pilot randomized controlled trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Impact of the association of strength training with neuromuscular electrostimulation on the functionality of individuals with functional decline during senescence: A systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
The cardio‐renal‐metabolic role of the nod‐like receptor protein‐3 and senescence‐associated secretory phenotype in early sodium/glucose cotransporter‐2 inhibitor therapy in people with diabetes who have had a myocardial infarction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Cellular senescence in acute human infectious disease: a systematic review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Tissue factor links inflammation, thrombosis, and senescence in COVID-19",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Differences in senescence of late Endothelial Progenitor Cells in non-smokers and smokers,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A Systematic Review of the Role of Senescent Cells in Uterine Leiomyomas: Deciphering Molecular Pathways and Exploring Therapeutic Prospects,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Inter-population differences in acetabular senescence: relevance in age-at-death estimation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Targeting cellular senescence in progenitor cells as a strategy to enhance bone regeneration by cell therapies: a systematic review of pre-clinical investigations,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
A bibliometric and visual analysis of the impact of senescence on tumor immunotherapy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Gene expression meta-analysis reveals aging and cellular senescence signatures in scleroderma-associated interstitial lung disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Apoptotic stress causes mtDNA release during senescence and drives the SASP,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Microglial Senescence and Activation in Healthy Aging and Alzheimer’s Disease: Systematic Review and Neuropathological Scoring,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Using proteomics and metabolomics to identify therapeutic targets for senescence mediated cancer: genetic complementarity method,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Biliverdin Reductase A Protects Lens Epithelial Cells against Oxidative Damage and Cellular Senescence in Age-Related Cataract,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Functional Network of the Long Non-coding RNA Growth Arrest-Specific Transcript 5 and Its Interacting Proteins in Senescence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Histological and Genetic Markers of Cellular Senescence in Keratinocyte Cancers and Actinic Keratosis: A Systematic Review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Ebselen, Iron Uptake Inhibitor, Alleviates Iron Overload-Induced Senescence-Like Neuronal Cells SH-SY5Y via Suppressing the mTORC1 Signaling Pathway",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Identification and validation of cellular senescence patterns to predict clinical outcomes and immunotherapeutic responses in lung adenocarcinoma,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Non-coding RNAs participate in interactions between senescence and gastrointestinal cancers,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Antioxidant strategies against cellular senescence: unveiling the power of synthetic versus natural antioxidants in a systematic review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Global research trends in gut microbiota and cellular senescence: a bibliometric and visual analysis from 2015 to 2025,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Cellular senescence and chronological age in various human tissues: A systematic review and meta‐analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Studenski 2011,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cesari 2009,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Perera 2006,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cruz-Jentoft 2019,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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