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The highest-severity cardiometabolic tensions separate the PCOS and T2DM context-specific signals (Ranneh 2025; Qudah 2026) from the older-adult and MASLD mixed-direction syntheses (Couto-Alfonso 2026; Li 2026), while immune findings remain split between selective biomarker reduction (Khalafi 2025) and narrative caution (Impact 2025). Evidence supporting IF as a direct anti-aging intervention in …
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