source · application/json
source_3802f09507f5469b
sha256 e487f6f97e04768be84e309a7f2a799ca2ef827d2074712a0c32d1497a4b38c0
by researka:v2 · 2026-05-27 16:11:01.377693+04:00
{"publication_id": "8b15f6df-c45d-4575-89cb-441c5de831bd", "traces": [{"candidate_sources": [{"doi": "10.14336/ad.2019.0621", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "url": null}, {"doi": "10.3346/jkms.2014.29.1.90", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "url": null}, {"doi": "10.1111/acel.12170", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "url": null}, {"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": null}, {"doi": "10.1111/acel.12898", "study": "Acarbose improves health and lifespan in aging HET3 mice", "url": null}], "claim": "Headline:** Polypharmacy Strategies with Acarbose for Dementia Risk Reduction in Type 2 Diabetes: Evidence from Subgroup Analyses and Combination Therapy", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.14336/ad.2019.0621", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "url": null}, {"doi": "10.3346/jkms.2014.29.1.90", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "url": null}, {"doi": "10.1111/acel.12170", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "url": null}, {"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": null}, {"doi": "10.1111/acel.12898", "study": "Acarbose improves health and lifespan in aging HET3 mice", "url": null}], "claim": "The cited A/B receipts support a specific working claim: reduced risk associated with acarbose was only observed... in non-users of metformin (adjusted hazard ratio, 0.635; 95% confidence interval, 0.481-0.837); users of all three drugs had the lowest risk of dementia (hazard ratio, 0.406; 95% confidence interval, 0.178-0.925). The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.14336/ad.2019.0621", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "url": null}, {"doi": "10.3346/jkms.2014.29.1.90", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "url": null}, {"doi": "10.1111/acel.12170", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "url": null}, {"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": null}, {"doi": "10.1111/acel.12898", "study": "Acarbose improves health and lifespan in aging HET3 mice", "url": null}], "claim": "Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.14336/ad.2019.0621", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "url": null}, {"doi": "10.3346/jkms.2014.29.1.90", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "url": null}, {"doi": "10.1111/acel.12170", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "url": null}, {"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": null}, {"doi": "10.1111/acel.12898", "study": "Acarbose improves health and lifespan in aging HET3 mice", "url": null}], "claim": "The discordance between acarbose's pronounced male-specific lifespan extension in genetically heterogeneous mice and its female-preferential dementia risk reduction in human type 2 diabetes patients suggests that sex-hormone interactions or differential gut-brain axis modulation may underpin its geroprotective effects, inviting mechanistic studies beyond glucose lowering.", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.14336/ad.2019.0621", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "url": null}, {"doi": "10.3346/jkms.2014.29.1.90", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "url": null}, {"doi": "10.1111/acel.12170", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "url": null}, {"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": null}, {"doi": "10.1111/acel.12898", "study": "Acarbose improves health and lifespan in aging HET3 mice", "url": null}], "claim": "Real tension: Acarbose increased median lifespan by 22% in male mice but only 5% in female mice (facts 3,4), whereas in human T2D patients, it reduced dementia risk only in women with an HR of 0.783 (fact 12).", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.14336/ad.2019.0621", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "url": null}, {"doi": "10.3346/jkms.2014.29.1.90", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "url": null}, {"doi": "10.1111/acel.12170", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "url": null}, {"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": null}, {"doi": "10.1111/acel.12898", "study": "Acarbose improves health and lifespan in aging HET3 mice", "url": null}], "claim": "`fact_id=187300` (`A_core`) — reduced risk associated with acarbose was only observed... in non-users of metformin (adjusted hazard ratio, 0.635; 95% confidence interval, 0.481-0.837) doi=10.14336/ad.2019.0621", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.14336/ad.2019.0621", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "url": null}, {"doi": "10.3346/jkms.2014.29.1.90", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "url": null}, {"doi": "10.1111/acel.12170", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "url": null}, {"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": null}, {"doi": "10.1111/acel.12898", "study": "Acarbose improves health and lifespan in aging HET3 mice", "url": null}], "claim": "`fact_id=187299` (`A_core`) — users of all three drugs had the lowest risk of dementia (hazard ratio, 0.406; 95% confidence interval, 0.178-0.925) doi=10.14336/ad.2019.0621", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.14336/ad.2019.0621", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "url": null}, {"doi": "10.3346/jkms.2014.29.1.90", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "url": null}, {"doi": "10.1111/acel.12170", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "url": null}, {"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": null}, {"doi": "10.1111/acel.12898", "study": "Acarbose improves health and lifespan in aging HET3 mice", "url": null}], "claim": "`fact_id=135514` (`A_core`) — The mean HbA1c at week 24 was significantly decreased approximately 0.7% from baseline in both acarbose and voglibose groups. doi=10.3346/jkms.2014.29.1.90", "claim_id": "claim_8"}, {"candidate_sources": [{"doi": "10.14336/ad.2019.0621", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "url": null}, {"doi": "10.3346/jkms.2014.29.1.90", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "url": null}, {"doi": "10.1111/acel.12170", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "url": null}, {"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": null}, {"doi": "10.1111/acel.12898", "study": "Acarbose improves health and lifespan in aging HET3 mice", "url": null}], "claim": "`fact_id=70369` (`A_core`) — Acarbose increased male median lifespan by 22% (P < 0.0001) doi=10.1111/acel.12170", "claim_id": "claim_9"}, {"candidate_sources": [{"doi": "10.14336/ad.2019.0621", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "url": null}, {"doi": "10.3346/jkms.2014.29.1.90", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "url": null}, {"doi": "10.1111/acel.12170", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "url": null}, {"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": null}, {"doi": "10.1111/acel.12898", "study": "Acarbose improves health and lifespan in aging HET3 mice", "url": null}], "claim": "`fact_id=135510` (`A_core`) — acarbose produced 51% decrease in maltose loaded diabetic rats doi=10.4236/jdm.2012.21013", "claim_id": "claim_10"}, {"candidate_sources": [{"doi": "10.14336/ad.2019.0621", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "url": null}, {"doi": "10.3346/jkms.2014.29.1.90", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "url": null}, {"doi": "10.1111/acel.12170", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "url": null}, {"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": null}, {"doi": "10.1111/acel.12898", "study": "Acarbose improves health and lifespan in aging HET3 mice", "url": null}], "claim": "`fact_id=108410` (`A_core`) — significantly increased (3%) in females only at 1,000 ppm doi=10.1111/acel.12898", "claim_id": "claim_11"}, {"candidate_sources": [{"doi": "10.14336/ad.2019.0621", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "url": null}, {"doi": "10.3346/jkms.2014.29.1.90", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "url": null}, {"doi": "10.1111/acel.12170", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "url": null}, {"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": null}, {"doi": "10.1111/acel.12898", "study": "Acarbose improves health and lifespan in aging HET3 mice", "url": null}], "claim": "_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._", "claim_id": "claim_12"}, {"candidate_sources": [{"doi": "10.14336/ad.2019.0621", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "url": null}, {"doi": "10.3346/jkms.2014.29.1.90", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "url": null}, {"doi": "10.1111/acel.12170", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "url": null}, {"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": null}, {"doi": "10.1111/acel.12898", "study": "Acarbose improves health and lifespan in aging HET3 mice", "url": null}], "claim": "Suggested citation:** Dom Lynch. (2026). Polypharmacy Strategies with Acarbose for Dementia Risk Reduction in Type 2 Diabetes: Evidence from Subgroup Analyses and Combination Therapy. ReseaRka Evidence Index. Version 1.0.", "claim_id": "claim_13"}, {"candidate_sources": [{"doi": "10.14336/ad.2019.0621", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "url": null}, {"doi": "10.3346/jkms.2014.29.1.90", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "url": null}, {"doi": "10.1111/acel.12170", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "url": null}, {"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": null}, {"doi": "10.1111/acel.12898", "study": "Acarbose improves health and lifespan in aging HET3 mice", "url": null}], "claim": "Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.", "claim_id": "claim_14"}]}
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