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source_3a9f29091c3e4fcc

sha256 e31607b832d26caa99e6fb919ceb0f99613226e26a0fdc387669c2fb81c11c7e

by researka:v2 · 2026-06-12 15:10:31.226665+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "af8247f3-a454-4caa-a1a1-f6759f6efc4e", "sources": [{"directness": "primary", "doi": "10.21203/rs.3.rs-7466146/v1", "risk_of_bias": "not appraised in public sidecar", "study": "The gerotherapeutic drugs rapamycin, acarbose, and phenylbutyrate extend lifespan and enhance healthy aging in house crickets."}, {"directness": "primary", "doi": "10.7759/cureus.98514", "risk_of_bias": "not appraised in public sidecar", "study": "The Mechanistic Target of Rapamycin (mTOR) Pathway as a Target of Anti-aging Therapies: The Role of Rapamycin and Its Analogs in the Regulation of Cellular Processes and Their Impact on Longevity."}, {"directness": "primary", "doi": "10.18632/aging.202674", "risk_of_bias": "not appraised in public sidecar", "study": "DNA- and telomere-damage does not limit lifespan: evidence from rapamycin."}, {"directness": "primary", "doi": "10.7554/eLife.16351", "risk_of_bias": "not appraised in public sidecar", "study": "Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice"}, {"directness": "primary", "doi": "10.1111/acel.12496", "risk_of_bias": "not appraised in public sidecar", "study": "Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer"}, {"directness": "primary", "doi": "10.1111/acel.12194", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction"}, {"directness": "primary", "doi": "10.1038/nature08221", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin fed late in life extends lifespan in genetically heterogeneous mice"}]}
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}

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