Derivation Web

source_3adfdabc12134f26

by researka:v2 · 2026-06-22 14:58:19.663666+04:00

{"publication_id": "9fd402e5-02e8-4ac2-acd2-1c6bf571b6e5", "traces": [{"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://pubmed.ncbi.nlm.nih.gov/38062873/"}, {"doi": "10.1039/c4ce01713g", "study": "Improving solubility of fisetin by cocrystallization", "url": null}, {"doi": "10.3390/ijms18040852", "study": "Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells", "url": "https://pubmed.ncbi.nlm.nih.gov/28420170/"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://pubmed.ncbi.nlm.nih.gov/20574928/"}, {"doi": "10.18632/aging.204275", "study": "Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle", "url": "https://pubmed.ncbi.nlm.nih.gov/36084954/"}], "claim": "What evidence fronts does fisetin occupy across animal model, cell or in-vitro model, and chemistry/formulation, and what remains untested?", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://pubmed.ncbi.nlm.nih.gov/38062873/"}, {"doi": "10.1039/c4ce01713g", "study": "Improving solubility of fisetin by cocrystallization", "url": null}, {"doi": "10.3390/ijms18040852", "study": "Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells", "url": "https://pubmed.ncbi.nlm.nih.gov/28420170/"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://pubmed.ncbi.nlm.nih.gov/20574928/"}, {"doi": "10.18632/aging.204275", "study": "Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle", "url": "https://pubmed.ncbi.nlm.nih.gov/36084954/"}], "claim": "Finding: DHC and fisetin caused dose-dependent reduction in viability and increase in apoptosis in PC3 cells at 72 h.", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://pubmed.ncbi.nlm.nih.gov/38062873/"}, {"doi": "10.1039/c4ce01713g", "study": "Improving solubility of fisetin by cocrystallization", "url": null}, {"doi": "10.3390/ijms18040852", "study": "Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells", "url": "https://pubmed.ncbi.nlm.nih.gov/28420170/"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://pubmed.ncbi.nlm.nih.gov/20574928/"}, {"doi": "10.18632/aging.204275", "study": "Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle", "url": "https://pubmed.ncbi.nlm.nih.gov/36084954/"}], "claim": "Answer: this 5-source primary bundle supports a receipt-backed scoping note for fisetin, spanning 2010-2023. The source facts cover 5 population context(s) and 5 intervention/exposure context(s). The bounded signal is context separation across animal model, cell or in-vitro model, and chemistry/formulation: the bundle identifies what has been measured and where the evidence separates, without establishing a causal, clinical, species-translated, or mechanistically integrated intervention claim. Representative source-extracted findings include: IC50 of fisetin 3.4 ± 0.3 μM on senescent cells versus 7.0 ± 0.4 μM on control cells; a 2.5-fold increase of fisetin solubility was achieved for FisNam; Fisetin (<20 µM) restored cell viability and repressed apoptosis, autophagy and ROS production in Tm-treated cells.", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://pubmed.ncbi.nlm.nih.gov/38062873/"}, {"doi": "10.1039/c4ce01713g", "study": "Improving solubility of fisetin by cocrystallization", "url": null}, {"doi": "10.3390/ijms18040852", "study": "Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells", "url": "https://pubmed.ncbi.nlm.nih.gov/28420170/"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://pubmed.ncbi.nlm.nih.gov/20574928/"}, {"doi": "10.18632/aging.204275", "study": "Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle", "url": "https://pubmed.ncbi.nlm.nih.gov/36084954/"}], "claim": "The selected receipts group because each carries a fact-level extraction for fisetin; they separate by context (animal model, cell or in-vitro model, and chemistry/formulation), so they are not interchangeable evidence for one endpoint.", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://pubmed.ncbi.nlm.nih.gov/38062873/"}, {"doi": "10.1039/c4ce01713g", "study": "Improving solubility of fisetin by cocrystallization", "url": null}, {"doi": "10.3390/ijms18040852", "study": "Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells", "url": "https://pubmed.ncbi.nlm.nih.gov/28420170/"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://pubmed.ncbi.nlm.nih.gov/20574928/"}, {"doi": "10.18632/aging.204275", "study": "Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle", "url": "https://pubmed.ncbi.nlm.nih.gov/36084954/"}], "claim": "Source-literature boundary for fisetin: the listed sources define separate evidence fronts. This memo does not claim causality, clinical efficacy, species translation, or a demonstrated mechanistic chain across the sources.", "claim_id": "claim_5"}]}

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