Derivation Web

source_3ae2e4f3583645ce

by researka:v2 · 2026-06-28 02:18:54.086623+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "9b717300-cdd0-4406-84b9-c92f5e1c17ec", "sources": [{"directness": "review-level", "doi": "10.1186/s12877-026-07025-5", "risk_of_bias": "not appraised in public sidecar", "study": "Evidence gaps in the effects of exercise on SASP-Related biomarkers in older adults: a systematic review and meta-analysis of randomized controlled trials"}, {"directness": "primary", "doi": "10.3390/ijms21124454", "risk_of_bias": "not appraised in public sidecar", "study": "The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification"}, {"directness": "primary", "doi": "10.1158/1538-7445.am2024-2954", "risk_of_bias": "not appraised in public sidecar", "study": "Abstract 2954: Androgen deprivation therapy (ADT) and senescence-associated secretory phenotype (SASP) in vitro: Correlation with SASP in tumor specimens as well as in the serum of patients after ADT"}, {"directness": "primary", "doi": "10.1186/s12967-026-08221-y", "risk_of_bias": "not appraised in public sidecar", "study": "Synergistic senolytic–regenerative therapy significantly extends healthspan and lifespan"}, {"directness": "primary", "doi": "10.1111/dme.70059", "risk_of_bias": "not appraised in public sidecar", "study": "The cardio‐renal‐metabolic role of the nod‐like receptor protein‐3 and senescence‐associated secretory phenotype in early sodium/glucose cotransporter‐2 inhibitor therapy in people with diabetes who have had a myocardial infarction"}, {"directness": "primary", "doi": "10.3389/fimmu.2022.1019313", "risk_of_bias": "not appraised in public sidecar", "study": "Senescence-associated secretory phenotype and its impact on oral immune homeostasis"}, {"directness": "primary", "doi": "10.1007/s12094-023-03364-6", "risk_of_bias": "not appraised in public sidecar", "study": "Senescence in head and neck squamous cell carcinoma: relationship between senescence-associated secretory phenotype (SASP) mRNA expression level and clinicopathological features"}, {"directness": "primary", "doi": "10.1002/2211-5463.13012", "risk_of_bias": "not appraised in public sidecar", "study": "ROCK inhibition modulates the senescence‐associated secretory phenotype (SASP) in oral keratinocytes"}, {"directness": "primary", "doi": "10.1093/gerona/glad265", "risk_of_bias": "not appraised in public sidecar", "study": "Proteomic Analysis of the Senescence-Associated Secretory Phenotype: GDF-15, IGFBP-2, and Cystatin-C Are Associated With Multiple Aging Traits"}, {"directness": "primary", "doi": "10.1093/geroni/igaf122.3519", "risk_of_bias": "not appraised in public sidecar", "study": "A Senescence Associated Secretory Phenotype (SASP) in Indolent Systemic Mastocytosis Compared to Healthy Controls"}, {"directness": "primary", "doi": "10.1002/alz.092727", "risk_of_bias": "not appraised in public sidecar", "study": "Senescence‐associated secretory phenotype (SASP) index in individuals across the Alzheimer’s disease continuum"}, {"directness": "review-level", "doi": "10.2147/PTT.S598115", "risk_of_bias": "not appraised in public sidecar", "study": "Inflammaging and Senescence-Associated Secretory Phenotype (SASP) in Psoriasis – A Narrative Review of Potential Mechanisms and Anti-Inflammaging Strategies"}, {"directness": "primary", "doi": "10.3390/cancers17244024", "risk_of_bias": "not appraised in public sidecar", "study": "The Impact of Senescence-Associated Secretory Phenotype (SASP) on Head and Neck Cancers: From Biology to Therapy"}, {"directness": "primary", "doi": "10.3390/antiox12111956", "risk_of_bias": "not appraised in public sidecar", "study": "Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation"}, {"directness": "primary", "doi": "10.1155/2019/4569614", "risk_of_bias": "not appraised in public sidecar", "study": "Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)"}, {"directness": "primary", "doi": "10.18632/aging.101452", "risk_of_bias": "not appraised in public sidecar", "study": "Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype"}, {"directness": "primary", "doi": "10.1371/journal.pbio.0060301", "risk_of_bias": "not appraised in public sidecar", "study": "Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}]}

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