source · application/json
source_40b304de1ae84a66
sha256 5f20a3af8c73a28aaefd03c6e1213ddc265d617409298e6b10a3df3b593c58fc
by researka:v2 · 2026-06-30 01:21:35.402446+04:00
{"publication_id": "ba5db8d2-cb82-4c8c-9e0f-d9b682baf215", "traces": [{"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "This paper synthesizes evidence on physical exercise effects across 55 accepted source papers and 2160 high-confidence extracted claims.", "claim_id": "claim_1"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "The evidence profile contains 11 direct clinical sources, 44 adjacent, review, or context sources, and no sources classified primarily as mechanistic or model-system evidence, with a high-density pairwise disagreement map across the evidence base.", "claim_id": "claim_2"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "Positive study-level signals are summarized in the safety and comorbidity, deficiency prevalence, contextual adjacent evidence outcome classes, null signals in the contextual adjacent evidence, cognitive and muscle function outcome classes, and negative signals in the contextual adjacent evidence outcome class. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect.", "claim_id": "claim_3"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "The conclusion is that physical exercise effects remains a bounded geroscience case: the retained direct, adjacent, and context evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "claim_id": "claim_4"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "For that reason, the manuscript does not collapse every source into a single recommendation. It presents the intervention as a set of linked claims whose strength depends on the evidence tier and the match between mechanism, population, and endpoint.", "claim_id": "claim_5"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "This synthesis evaluates evidence on physical exercise effects across 55 included source papers and 2160 high-confidence extracted claims. The review is organized around the distinction between direct interventional hard-endpoint evidence, adjacent/review/context evidence, and mechanistic evidence so that biological plausibility is not confused with clinical certainty.", "claim_id": "claim_6"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "The corpus contains 11 direct clinical sources, 44 adjacent, review, or context sources, and no sources classified primarily as mechanistic or model-system evidence. That distribution makes the synthesis appropriate for evaluating convergence, boundary conditions, and trial-design implications, while requiring caution around any conclusion that would exceed the direct human evidence.", "claim_id": "claim_7"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "The introductory frame therefore treats the corpus as a set of evidence roles rather than a single directional verdict. Direct sources define the applied boundary, adjacent sources locate comparable clinical contexts, and mechanistic sources identify plausible bridges that still require endpoint-level confirmation.", "claim_id": "claim_8"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "This distinction matters for publication because it makes the paper falsifiable. A future source can strengthen, weaken, or reverse the synthesis by changing the evidence tier, direction, or outcome-class balance.", "claim_id": "claim_9"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "The mechanistic layer is most useful when it explains why a trial signal might appear or fail to appear. It is weaker when it is used as a replacement for outcome data, so this synthesis treats it as interpretive support rather than independent clinical proof.", "claim_id": "claim_10"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "Null findings have a specific role in this evidence model. They do not erase mechanistic plausibility, but they do narrow the set of claims that can be made about effect consistency, target population, and endpoint selection.", "claim_id": "claim_11"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "Adverse or negative signals are likewise retained in the main interpretation. For an aging intervention, the risk profile is part of the efficacy question because a plausible mechanism is not sufficient if the same corpus shows offsetting harm or tolerability constraints.", "claim_id": "claim_12"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "The evidence base also distinguishes breadth from certainty. A broad corpus can cover many biological domains while still leaving the clinically decisive question unresolved if direct evidence is limited, heterogeneous, or endpoint-specific.", "claim_id": "claim_13"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "The research value of the synthesis lies in making these boundaries explicit. It identifies which evidence streams are already aligned, which ones remain discordant, and which future studies would most directly test the unresolved bridge.", "claim_id": "claim_14"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "The background evidence for physical exercise effects is heterogeneous rather than uniformly confirmatory. Direct clinical sources such as Suikkanen 2025, Arici 2025, Adnan 2026 are interpreted separately from mechanistic studies such as the retained evidence base, because these evidence roles answer different questions about aging biology and clinical translation.", "claim_id": "claim_15"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "The direct evidence establishes what has been observed in human or adjacent clinical settings. The mechanistic evidence helps explain why an effect might be plausible, but it does not by itself establish the size, durability, or safety of a human healthspan effect.", "claim_id": "claim_16"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "Across the retained sources, positive signals cluster around the safety and comorbidity, deficiency prevalence, contextual adjacent evidence outcome classes; null signals around the contextual adjacent evidence, cognitive and muscle function outcome classes; and negative or adverse signals around the contextual adjacent evidence outcome class. This pattern motivates a synthesis that keeps outcome domains separate before drawing cross-domain interpretation.", "claim_id": "claim_17"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "The study-level structure also prevents selective emphasis. Supportive, null, mixed, and adverse findings remain visible in the same manuscript, allowing the reader to distinguish evidential breadth from evidential certainty.", "claim_id": "claim_18"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": 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"not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "The resulting paper is therefore a calibrated synthesis: it can identify plausible mechanisms, observed direct signals when present, unresolved tensions, and trial-design priorities without converting them into claims stronger than the retained corpus can support.", "claim_id": "claim_19"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": 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"not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating. Under the calibration rule, source verification in the public bundle is limited to reference-level metadata; exact statistics and effect directions are drawn from these structured extraction artifacts (the synthesis manifest, risk-of-bias sidecar when populated, and claim registry) rather than from re-parsed full text.", "claim_id": "claim_20"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "Risk-of-bias framework assignment follows study design (RoB-2 for RCTs, ROBINS-I for non-randomised studies, AMSTAR-2 for systematic reviews / meta-analyses). Public appraisal claims are limited to populated `risk_of_bias.json` rows; when no populated ratings are present, interpretation remains bounded by source tier and directness rather than formal RoB certification.", "claim_id": "claim_21"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "Evidence-tension synthesis: claims grouped by outcome class (cardiometabolic, cognitive, contextual adjacent evidence, deficiency prevalence, dosing and pharmacokinetics, frailty, muscle function, safety and comorbidity, skeletal, fracture, and bone); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.", "claim_id": "claim_22"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.", "claim_id": "claim_23"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "Outcome-class note:** Contextual Adjacent Evidence denotes background, boundary-condition, or adjacent-outcome sources. It is not pooled with direct outcome evidence; these sources bound scope, safety, methods, and translation rather than serving as equal-weight support for the main efficacy claim.", "claim_id": "claim_24"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "| Evidence domain | Corpus slice | Strongest signal | Directness | Main limitation |", "claim_id": "claim_25"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "| Physical Exercise Effects / Contextual Adjacent Evidence | n=35; claims=1431 | significant source statistic in 25/35 sources; receipt-level direction coded unclear | 3 direct; 11 indirect; 1 protocol; 20 review | limited corpus depth in this outcome class |", "claim_id": "claim_26"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "| Physical Exercise Effects / Frailty | n=1; claims=105 | significant source statistic in 1/1 sources; receipt-level direction coded null | 1 review | single-source slice; hypothesis-generating |", "claim_id": "claim_27"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "Contextual Adjacent Evidence: n=35; claims=1431; mixed signal in 20/35 sources | directness: 3 direct; 11 indirect; 20 review; 1 protocol; main limitation: directionally heterogeneous.", "claim_id": "claim_28"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "The cardiometabolic evidence base for physical exercise effects spans three principal sources, each anchored in different study designs and populations. Pela 2025 reported on a randomized control trial conducted in frail, sarcopenic older subjects aged 70 years or older, evaluating a two-year adapted physical exercise program combined with nutritional counselling on cardio-sarcopenia syndrome, with multiple endpoints reaching statistical significance (P = 0.004, P = 0.037, P = 0.034, P < 0.001, P = 0.012, P < 0.05, P = 0.038, P < 0.005, P = 0.003). Ancin-Oses 2025 contributed a systematic review with meta-analysis of randomized controlled trials examining physical exercise on metabolic syndrome in psychotic disorders, pooling across enrolled trials. Kazeminasab 2024 provided a systematic review and meta-analysis of clinical studies evaluating intermittent fasting combined with physical exercise on cardiometabolic outcomes. Together these sources define a cardiometabolic outcome class whose evidence strength depends on population, intervention pairing, and endpoint specificity.", "claim_id": "claim_29"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1590/1414-431X2025e14194", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/1414-431X2025e14194"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-024", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1590/S0004-2803.24612025-024"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05575-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Effects of different physical exercise programs on blood pressure in overweight children and adolescents: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12887-025-05575-y"}, {"directness": "review-level", "doi": "10.1007/s00520-025-10194-5", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00520-025-10194-5"}, {"directness": "primary", "doi": "10.1038/s41598-025-26683-w", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The role of physical exercise in enhancing Health, quality of life and joy among older adults", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41598-025-26683-w"}], "claim": "Mechanistically, the divergence between Pela 2025 and Ancin-Oses 2025 maps onto population substrate and intervention pairing. Pela 2025 enrolled frail, sarcopenic older adults with low muscle function — a clinical RCT population in which a combined adapted exercise plus nutritional counselling regimen can plausibly act on both the muscular and cardiovascular axes of cardio-sarcopenia. Ancin-Oses 2025, by contrast, drew from trials in psychotic disorders, where antipsychotic medication burden, lifestyle factors, and diagnostic heterogeneity may attenuate the cardiometabolic signal of exercise alone. Kazeminasab 2024 supplies a third mechanistic context — combined intermittent fasting plus exercise — in which the synergistic metabolic stress of energy restriction amplifies weight, lipid, and blood pressure effects beyond exercise monotherapy. The mechanistic substrate underlying these functional findings therefore includes the population's baseline cardiometabolic risk, the presence or absence of dietary co-interventions, and the duration of follow-up, all of which vary across the three sources.", "claim_id": "claim_30"}]}
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