Derivation Web

source_40cbe26918914fbe

by researka:v2 · 2026-06-24 20:43:58.249203+04:00

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Grouped by direction, directionally favorable: 1 receipt(s) | other/mixed: 4 receipt(s). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. Concrete source-level examples: This revealed a significant effect of treatment on telomere dynamics (d=0.36); The liver disease cohort (HR 1.22, 95% CI 0.99-1.51) had increased mortality risk with shorter TL; but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16).", "type": "claim"}, {"id": "claim_8", "text": "null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.", "type": "claim"}, {"id": "claim_9", "text": "other/mixed: Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population — The liver disease cohort (HR 1.22, 95% CI 0.99-1.51) had increased mortality risk with shorter TL", "type": "claim"}, {"id": "claim_10", "text": "other/mixed: Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16)", "type": "claim"}, {"id": "claim_11", "text": "other/mixed: The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238].", "type": "claim"}, {"id": "claim_12", "text": "directionally favorable: Short telomere length is associated with impaired cognitive performance in European ancestry cohorts — longer telomeres were associated with better scores on DSST (β=0.051 per s.d.-increase of TL; 95% CI: 0.024, 0.077; P=0.0002)", "type": "claim"}, {"id": "claim_13", "text": "Specific moderators in this bundle are population/indication (13,894 cases and 71,672 controls from 28 studies in 25 articles; European ancestry cohorts (N=17,052; mean age=59.2±8.8 years); UK Biobank participants aged 60 and older; interventional studies manipulating oxidative stress; liver disease cohort), study design/evidence type (primary/review). Single primary-study estimates are separated from pooled review or meta-analytic estimates rather than treated as interchangeable.", "type": "claim"}, {"id": "claim_14", "text": "The selected receipts group because each carries a fact-level extraction for telomere; they separate by context (human clinical/observational and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim.", "type": "claim"}, {"id": "claim_15", "text": "The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.", "type": "claim"}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1016/j.arr.2023.101854", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Does oxidative stress shorten telomeres in vivo? A meta-analysis", "type": "source", "url": "https://doi.org/10.1016/j.arr.2023.101854", "year": 2023}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1002/hep4.1803", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population", "type": "source", "url": "https://doi.org/10.1002/hep4.1803", "year": 2021}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.13017", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "type": "source", "url": "https://doi.org/10.1111/acel.13017", "year": 2019}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1158/1055-9965.epi-16-0968", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "type": "source", "url": "https://doi.org/10.1158/1055-9965.epi-16-0968", "year": 2017}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1038/tp.2017.73", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Short telomere length is associated with impaired cognitive performance in European ancestry cohorts", "type": "source", "url": "https://doi.org/10.1038/tp.2017.73", "year": 2017}], "publication_id": "5656b611-9e22-4b55-bce0-289625f554db", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 5, "included": 5, "included_or_retained": 5, "screened": 5, "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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