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# Alpha memo: metformin adaptation
**One-sentence alpha:** Population-level protection from metformin against hyperemesis gravidarum may coexist with, and be partly separable from, a direct fetal-islet exposure that can amplify glucose-stimulated insulin secretion in non-human primate offspring.

**Receipt 1:** Sillis et al. (2025), *Metformin and Hyperemesis Gravidarum: Reframing a Metabolic Diso…