source · application/json
source_46ab1c23bdf94bc1
sha256 beda090ede12b3953937d189d3eb0a6aa73a0508bf0e3503bae599d5a515be8a
by researka:v2 · 2026-07-04 17:39:59.898644+04:00
{"publication_id": "bde27e52-8cfd-4e9f-8721-e899352f3a58", "traces": [{"candidate_sources": [{"directness": "primary", "doi": "10.1111/acel.12898", "effect": "not extracted", "endpoint": "not extracted", "population": "female mice", "source_id": "source_1", "study": "Acarbose improves health and lifespan in aging HET3 mice", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.12898"}, {"directness": "primary", "doi": "10.1093/gerona/glz177", "effect": "not extracted", "endpoint": "not extracted", "population": "HET3 mice", "source_id": "source_2", "study": "Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1093/gerona/glz177"}, {"directness": "primary", "doi": "10.4236/jdm.2012.21013", "effect": "not extracted", "endpoint": "not extracted", "population": "maltose loaded diabetic rats", "source_id": "source_3", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "support_kind": "candidate_source_row", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"directness": "primary", "doi": "10.1128/msphere.00528-18", "effect": "not extracted", "endpoint": "not extracted", "population": "mice fed high-starch diet", "source_id": "source_4", "study": "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1128/msphere.00528-18"}, {"directness": "primary", "doi": "10.1371/journal.pone.0079697", "effect": "not extracted", "endpoint": "not extracted", "population": "diabetic rats", "source_id": "source_5", "study": "Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1371/journal.pone.0079697"}], "claim": "Across retrieved source-level receipts for acarbose, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?", "claim_id": "claim_1"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1111/acel.12898", "effect": "not extracted", "endpoint": "not extracted", "population": "female mice", "source_id": "source_1", "study": "Acarbose improves health and lifespan in aging HET3 mice", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.12898"}, {"directness": "primary", "doi": "10.1093/gerona/glz177", "effect": "not extracted", "endpoint": "not extracted", "population": "HET3 mice", "source_id": "source_2", "study": "Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1093/gerona/glz177"}, {"directness": "primary", "doi": "10.4236/jdm.2012.21013", "effect": "not extracted", "endpoint": "not extracted", "population": "maltose loaded diabetic rats", "source_id": "source_3", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "support_kind": "candidate_source_row", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"directness": "primary", "doi": "10.1128/msphere.00528-18", "effect": "not extracted", "endpoint": "not extracted", "population": "mice fed high-starch diet", "source_id": "source_4", "study": "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1128/msphere.00528-18"}, {"directness": "primary", "doi": "10.1371/journal.pone.0079697", "effect": "not extracted", "endpoint": "not extracted", "population": "diabetic rats", "source_id": "source_5", "study": "Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1371/journal.pone.0079697"}], "claim": "Finding: 8-week treatment with acarbose significantly decreased fasting blood glucose.", "claim_id": "claim_2"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1111/acel.12898", "effect": "not extracted", "endpoint": "not extracted", "population": "female mice", "source_id": "source_1", "study": "Acarbose improves health and lifespan in aging HET3 mice", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.12898"}, {"directness": "primary", "doi": "10.1093/gerona/glz177", "effect": "not extracted", "endpoint": "not extracted", "population": "HET3 mice", "source_id": "source_2", "study": "Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1093/gerona/glz177"}, {"directness": "primary", "doi": "10.4236/jdm.2012.21013", "effect": "not extracted", "endpoint": "not extracted", "population": "maltose loaded diabetic rats", "source_id": "source_3", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "support_kind": "candidate_source_row", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"directness": "primary", "doi": "10.1128/msphere.00528-18", "effect": "not extracted", "endpoint": "not extracted", "population": "mice fed high-starch diet", "source_id": "source_4", "study": "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1128/msphere.00528-18"}, {"directness": "primary", "doi": "10.1371/journal.pone.0079697", "effect": "not extracted", "endpoint": "not extracted", "population": "diabetic rats", "source_id": "source_5", "study": "Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1371/journal.pone.0079697"}], "claim": "| Outcome family | Receipt | Evidence role | Population/setting | Metric | Extracted finding |", "claim_id": "claim_3"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1111/acel.12898", "effect": "not extracted", "endpoint": "not extracted", "population": "female mice", "source_id": "source_1", "study": "Acarbose improves health and lifespan in aging HET3 mice", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.12898"}, {"directness": "primary", "doi": "10.1093/gerona/glz177", "effect": "not extracted", "endpoint": "not extracted", "population": "HET3 mice", "source_id": "source_2", "study": "Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1093/gerona/glz177"}, {"directness": "primary", "doi": "10.4236/jdm.2012.21013", "effect": "not extracted", "endpoint": "not extracted", "population": "maltose loaded diabetic rats", "source_id": "source_3", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "support_kind": "candidate_source_row", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"directness": "primary", "doi": "10.1128/msphere.00528-18", "effect": "not extracted", "endpoint": "not extracted", "population": "mice fed high-starch diet", "source_id": "source_4", "study": "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1128/msphere.00528-18"}, {"directness": "primary", "doi": "10.1371/journal.pone.0079697", "effect": "not extracted", "endpoint": "not extracted", "population": "diabetic rats", "source_id": "source_5", "study": "Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1371/journal.pone.0079697"}], "claim": "| outcome-specific | Acarbose improves health and lifespan in aging HET3 mice | directionally favorable | female mice | - | significantly increased (3%) in females only at 1,000 ppm |", "claim_id": "claim_4"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1111/acel.12898", "effect": "not extracted", "endpoint": "not extracted", "population": "female mice", "source_id": "source_1", "study": "Acarbose improves health and lifespan in aging HET3 mice", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.12898"}, {"directness": "primary", "doi": "10.1093/gerona/glz177", "effect": "not extracted", "endpoint": "not extracted", "population": "HET3 mice", "source_id": "source_2", "study": "Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1093/gerona/glz177"}, {"directness": "primary", "doi": "10.4236/jdm.2012.21013", "effect": "not extracted", "endpoint": "not extracted", "population": "maltose loaded diabetic rats", "source_id": "source_3", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "support_kind": "candidate_source_row", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"directness": "primary", "doi": "10.1128/msphere.00528-18", "effect": "not extracted", "endpoint": "not extracted", "population": "mice fed high-starch diet", "source_id": "source_4", "study": "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1128/msphere.00528-18"}, {"directness": "primary", "doi": "10.1371/journal.pone.0079697", "effect": "not extracted", "endpoint": "not extracted", "population": "diabetic rats", "source_id": "source_5", "study": "Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1371/journal.pone.0079697"}], "claim": "| outcome-specific | Effect of quercetin on postprandial glucose excursion after mono- and... | directionally favorable | maltose loaded diabetic rats | - | acarbose produced 51% decrease in maltose loaded diabetic rats |", "claim_id": "claim_5"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1111/acel.12898", "effect": "not extracted", "endpoint": "not extracted", "population": "female mice", "source_id": "source_1", "study": "Acarbose improves health and lifespan in aging HET3 mice", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.12898"}, {"directness": "primary", "doi": "10.1093/gerona/glz177", "effect": "not extracted", "endpoint": "not extracted", "population": "HET3 mice", "source_id": "source_2", "study": "Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1093/gerona/glz177"}, {"directness": "primary", "doi": "10.4236/jdm.2012.21013", "effect": "not extracted", "endpoint": "not extracted", "population": "maltose loaded diabetic rats", "source_id": "source_3", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "support_kind": "candidate_source_row", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"directness": "primary", "doi": "10.1128/msphere.00528-18", "effect": "not extracted", "endpoint": "not extracted", "population": "mice fed high-starch diet", "source_id": "source_4", "study": "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1128/msphere.00528-18"}, {"directness": "primary", "doi": "10.1371/journal.pone.0079697", "effect": "not extracted", "endpoint": "not extracted", "population": "diabetic rats", "source_id": "source_5", "study": "Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1371/journal.pone.0079697"}], "claim": "| outcome-specific | Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in... | directionally favorable | diabetic rats | - | 8-week treatment with acarbose significantly decreased fasting blood glucose |", "claim_id": "claim_6"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1111/acel.12898", "effect": "not extracted", "endpoint": "not extracted", "population": "female mice", "source_id": "source_1", "study": "Acarbose improves health and lifespan in aging HET3 mice", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.12898"}, {"directness": "primary", "doi": "10.1093/gerona/glz177", "effect": "not extracted", "endpoint": "not extracted", "population": "HET3 mice", "source_id": "source_2", "study": "Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1093/gerona/glz177"}, {"directness": "primary", "doi": "10.4236/jdm.2012.21013", "effect": "not extracted", "endpoint": "not extracted", "population": "maltose loaded diabetic rats", "source_id": "source_3", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "support_kind": "candidate_source_row", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"directness": "primary", "doi": "10.1128/msphere.00528-18", "effect": "not extracted", "endpoint": "not extracted", "population": "mice fed high-starch diet", "source_id": "source_4", "study": "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1128/msphere.00528-18"}, {"directness": "primary", "doi": "10.1371/journal.pone.0079697", "effect": "not extracted", "endpoint": "not extracted", "population": "diabetic rats", "source_id": "source_5", "study": "Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1371/journal.pone.0079697"}], "claim": "| Outcome family | Receipt | Evidence role | Population/setting | Metric | Extracted finding |", "claim_id": "claim_7"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1111/acel.12898", "effect": "not extracted", "endpoint": "not extracted", "population": "female mice", "source_id": "source_1", "study": "Acarbose improves health and lifespan in aging HET3 mice", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.12898"}, {"directness": "primary", "doi": "10.1093/gerona/glz177", "effect": "not extracted", "endpoint": "not extracted", "population": "HET3 mice", "source_id": "source_2", "study": "Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1093/gerona/glz177"}, {"directness": "primary", "doi": "10.4236/jdm.2012.21013", "effect": "not extracted", "endpoint": "not extracted", "population": "maltose loaded diabetic rats", "source_id": "source_3", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "support_kind": "candidate_source_row", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"directness": "primary", "doi": "10.1128/msphere.00528-18", "effect": "not extracted", "endpoint": "not extracted", "population": "mice fed high-starch diet", "source_id": "source_4", "study": "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1128/msphere.00528-18"}, {"directness": "primary", "doi": "10.1371/journal.pone.0079697", "effect": "not extracted", "endpoint": "not extracted", "population": "diabetic rats", "source_id": "source_5", "study": "Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1371/journal.pone.0079697"}], "claim": "This receipt-backed scoping note has one bounded signal: acarbose shows endpoint-specific favorable signals with context limits across this 5-source primary bundle (2012-2019). Evidence role grouping: direction-bearing receipts: 3; null/mixed metric-scope caveat receipts: 0; context/antecedent/model receipts: 2 excluded from effect support. The source facts cover 5 population/setting context(s) and 3 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. This is a heterogeneous indication/context map, not a unified disease-specific or endpoint-family claim. Concrete contrast: other/mixed: Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging: acarbose and 17-α estradiol do not strongly alter these phenotypes; directionally favorable: Acarbose improves health and lifespan in aging HET3 mice: significantly increased (3%) in females only at 1,000 ppm.", "claim_id": "claim_8"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1111/acel.12898", "effect": "not extracted", "endpoint": "not extracted", "population": "female mice", "source_id": "source_1", "study": "Acarbose improves health and lifespan in aging HET3 mice", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.12898"}, {"directness": "primary", "doi": "10.1093/gerona/glz177", "effect": "not extracted", "endpoint": "not extracted", "population": "HET3 mice", "source_id": "source_2", "study": "Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1093/gerona/glz177"}, {"directness": "primary", "doi": "10.4236/jdm.2012.21013", "effect": "not extracted", "endpoint": "not extracted", "population": "maltose loaded diabetic rats", "source_id": "source_3", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "support_kind": "candidate_source_row", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"directness": "primary", "doi": "10.1128/msphere.00528-18", "effect": "not extracted", "endpoint": "not extracted", "population": "mice fed high-starch diet", "source_id": "source_4", "study": "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1128/msphere.00528-18"}, {"directness": "primary", "doi": "10.1371/journal.pone.0079697", "effect": "not extracted", "endpoint": "not extracted", "population": "diabetic rats", "source_id": "source_5", "study": "Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1371/journal.pone.0079697"}], "claim": "null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.", "claim_id": "claim_9"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1111/acel.12898", "effect": "not extracted", "endpoint": "not extracted", "population": "female mice", "source_id": "source_1", "study": "Acarbose improves health and lifespan in aging HET3 mice", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.12898"}, {"directness": "primary", "doi": "10.1093/gerona/glz177", "effect": "not extracted", "endpoint": "not extracted", "population": "HET3 mice", "source_id": "source_2", "study": "Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1093/gerona/glz177"}, {"directness": "primary", "doi": "10.4236/jdm.2012.21013", "effect": "not extracted", "endpoint": "not extracted", "population": "maltose loaded diabetic rats", "source_id": "source_3", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "support_kind": "candidate_source_row", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"directness": "primary", "doi": "10.1128/msphere.00528-18", "effect": "not extracted", "endpoint": "not extracted", "population": "mice fed high-starch diet", "source_id": "source_4", "study": "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1128/msphere.00528-18"}, {"directness": "primary", "doi": "10.1371/journal.pone.0079697", "effect": "not extracted", "endpoint": "not extracted", "population": "diabetic rats", "source_id": "source_5", "study": "Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1371/journal.pone.0079697"}], "claim": "directionally favorable: Acarbose improves health and lifespan in aging HET3 mice — significantly increased (3%) in females only at 1,000 ppm", "claim_id": "claim_10"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1111/acel.12898", "effect": "not extracted", "endpoint": "not extracted", "population": "female mice", "source_id": "source_1", "study": "Acarbose improves health and lifespan in aging HET3 mice", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.12898"}, {"directness": "primary", "doi": "10.1093/gerona/glz177", "effect": "not extracted", "endpoint": "not extracted", "population": "HET3 mice", "source_id": "source_2", "study": "Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1093/gerona/glz177"}, {"directness": "primary", "doi": "10.4236/jdm.2012.21013", "effect": "not extracted", "endpoint": "not extracted", "population": "maltose loaded diabetic rats", "source_id": "source_3", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "support_kind": "candidate_source_row", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"directness": "primary", "doi": "10.1128/msphere.00528-18", "effect": "not extracted", "endpoint": "not extracted", "population": "mice fed high-starch diet", "source_id": "source_4", "study": "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1128/msphere.00528-18"}, {"directness": "primary", "doi": "10.1371/journal.pone.0079697", "effect": "not extracted", "endpoint": "not extracted", "population": "diabetic rats", "source_id": "source_5", "study": "Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1371/journal.pone.0079697"}], "claim": "directionally favorable: Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats — acarbose produced 51% decrease in maltose loaded diabetic rats", "claim_id": "claim_11"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1111/acel.12898", "effect": "not extracted", "endpoint": "not extracted", "population": "female mice", "source_id": "source_1", "study": "Acarbose improves health and lifespan in aging HET3 mice", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.12898"}, {"directness": "primary", "doi": "10.1093/gerona/glz177", "effect": "not extracted", "endpoint": "not 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