source · application/json
source_4a82bc6243594eb0
sha256 2966ee96489cfee31241358433720972a9a4127078cd619e4d7537a95b134ffb
by researka:v2 · 2026-06-23 08:26:01.450898+04:00
{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "bd88fdac-646d-49da-ad47-a3e928cc057a", "sources": [{"directness": "primary", "doi": "10.1186/s12979-023-00364-6", "risk_of_bias": "not appraised in public sidecar", "study": "Immunogenicity and safety of quadrivalent influenza vaccine among young and older adults in Tianjin, China: implication of immunosenescence as a risk factor"}, {"directness": "primary", "doi": "10.1186/s12979-026-00560-0", "risk_of_bias": "not appraised in public sidecar", "study": "Kaempferol alleviates T-cell immunosenescence and inflammaging in aged mice via the SIRT3-LKB1-AMPK-mitophagy pathway"}, {"directness": "primary", "doi": "10.1080/21645515.2026.2617728", "risk_of_bias": "not appraised in public sidecar", "study": "BC02-adjuvanted varicella-zoster virus glycoprotein E subunit vaccine overcomes immunosenescence to induce robust neutralizing antibodies and multifunctional T-cell immunity in seropositive aged murine models"}, {"directness": "primary", "doi": "10.1016/j.xcrm.2025.102484", "risk_of_bias": "not appraised in public sidecar", "study": "Physical activity decreases cancer burden by alleviating immunosenescence-related inflammation and improving overall immunity"}, {"directness": "primary", "doi": "10.3390/diseases14010026", "risk_of_bias": "not appraised in public sidecar", "study": "Predictors of Severe Herpes Zoster: Contributions of Immunosenescence, Metabolic Risk, and Lifestyle Behaviors"}, {"directness": "primary", "doi": "10.1038/s41514-026-00340-6", "risk_of_bias": "not appraised in public sidecar", "study": "Biological age and immunosenescence in Colombian centenarians"}, {"directness": "primary", "doi": "10.1111/acel.70077", "risk_of_bias": "not appraised in public sidecar", "study": "Immunosenescence Profile Is Associated With Increased Susceptibility to Severe COVID ‐19"}, {"directness": "primary", "doi": "10.1002/agm2.12342", "risk_of_bias": "not appraised in public sidecar", "study": "Fasting and calorie restriction modulate age‐associated immunosenescence and inflammaging"}, {"directness": "primary", "doi": "10.1007/s11102-025-01632-y", "risk_of_bias": "not appraised in public sidecar", "study": "The impact of growth hormone (GH) on immunosenescence: exploring the role of B and T cells"}, {"directness": "primary", "doi": "10.3390/nu17040667", "risk_of_bias": "not appraised in public sidecar", "study": "Preliminary Data on the Senolytic Effects of Agrimonia pilosa Ledeb. Extract Containing Agrimols for Immunosenescence in Middle-Aged Humans: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study"}, {"directness": "primary", "doi": "10.1186/s12979-025-00504-0", "risk_of_bias": "not appraised in public sidecar", "study": "CD31 + naïve T cells associate with immunosenescence and responsiveness to multiple vaccines in older adults"}, {"directness": "primary", "doi": "10.3389/fimmu.2025.1570441", "risk_of_bias": "not appraised in public sidecar", "study": "Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial"}, {"directness": "primary", "doi": "10.3389/fmed.2026.1729112", "risk_of_bias": "not appraised in public sidecar", "study": "Age-related changes in circulating immune factors reveal biomarkers of immunosenescence"}, {"directness": "primary", "doi": "10.3389/fimmu.2025.1547854", "risk_of_bias": "not appraised in public sidecar", "study": "Living in endemic area for infectious diseases is associated to differences in immunosenescence and inflammatory signatures"}, {"directness": "primary", "doi": "10.1186/s12979-024-00491-8", "risk_of_bias": "not appraised in public sidecar", "study": "Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy"}, {"directness": "primary", "doi": "10.1093/gerona/glag095", "risk_of_bias": "not appraised in public sidecar", "study": "Immunosenescence and cytomegalovirus-associated immune signatures on severe acute respiratory syndrome coronavirus 2 booster responses"}, {"directness": "primary", "doi": "10.1002/advs.202407398", "risk_of_bias": "not appraised in public sidecar", "study": "MAM‐STAT3‐Driven Mitochondrial Ca +2 Upregulation Contributes to Immunosenescence in Type A Mandibuloacral Dysplasia Patients"}, {"directness": "primary", "doi": "10.1186/s12979-025-00506-y", "risk_of_bias": "not appraised in public sidecar", "study": "Enhancing flu vaccine responses in older adults: preliminary insights from the ISOLDA study on immunosenescence and antioxidant and anti-inflammatory approaches"}, {"directness": "primary", "doi": "10.31083/RCM45403", "risk_of_bias": "not appraised in public sidecar", "study": "Lymphocyte-To-Monocyte Ratio is Partially Mediated in Age-Related Cardiovascular Mortality in HFpEF: Immunosenescence, Inflamm-Aging, and Longevity"}, {"directness": "primary", "doi": "10.1186/s12979-022-00309-5", "risk_of_bias": "not appraised in public sidecar", "study": "Aging, inflammaging and immunosenescence as risk factors of severe COVID-19"}, {"directness": "review-level", "doi": "10.3389/fnagi.2026.1776458", "risk_of_bias": "not appraised in public sidecar", "study": "Immunosenescence and its impact on ischemic stroke risk and outcomes in older adults: a systematic review"}, {"directness": "primary", "doi": "10.1186/s12906-024-04732-7", "risk_of_bias": "not appraised in public sidecar", "study": "A randomized controlled trial to assess the efficacy of standardized tai chi in prefrail older adults with immunosenescence: design and protocol"}, {"directness": "primary", "doi": "10.1111/acel.14491", "risk_of_bias": "not appraised in public sidecar", "study": "Disease Aggravation With Age in an Experimental Model of Multiple Sclerosis: Role of Immunosenescence"}, {"directness": "primary", "doi": "10.1111/acel.70082", "risk_of_bias": "not appraised in public sidecar", "study": "Deciphering Immunosenescence From Child to Frailty: Transcriptional Changes, Inflammation Dynamics, and Adaptive Immune Alterations"}, {"directness": "primary", "doi": "10.3389/fcell.2025.1686947", "risk_of_bias": "not appraised in public sidecar", "study": "The pathophysiological mechanisms of immunosenescence in coronary artery disease"}, {"directness": "review-level", "doi": "10.21037/atm-22-4405", "risk_of_bias": "not appraised in public sidecar", "study": "Immunosenescence is a therapeutic target for frailty in older adults: a narrative review"}, {"directness": "primary", "doi": "10.1111/acel.70548", "risk_of_bias": "not appraised in public sidecar", "study": "Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways"}, {"directness": "primary", "doi": "10.1186/s12915-025-02484-5", "risk_of_bias": "not appraised in public sidecar", "study": "Aging-associated transcriptional programs in T cells signify constituents of TGF-β signaling for immunosenescence"}, {"directness": "primary", "doi": "10.3390/ijms26031258", "risk_of_bias": "not appraised in public sidecar", "study": "Markers of Type 2 Inflammation and Immunosenescence Are Upregulated in Localized Scleroderma"}, {"directness": "primary", "doi": "10.3390/biomedicines13030721", "risk_of_bias": "not appraised in public sidecar", "study": "Gene Expression Changes as Biomarkers of Immunosenescence in Bulgarian Individuals of Active Age"}, {"directness": "primary", "doi": "10.3390/jcm14238313", "risk_of_bias": "not appraised in public sidecar", "study": "Age Versus Immunity: Dietary Influences on Immunosenescence"}, {"directness": "primary", "doi": "10.1186/s12916-025-04545-6", "risk_of_bias": "not appraised in public sidecar", "study": "HIV infection and immunosenescence: challenges and intervention strategies"}, {"directness": "primary", "doi": "10.3389/fimmu.2026.1792954", "risk_of_bias": "not appraised in public sidecar", "study": "Bridging aging and colorectal cancer: synergistic roles of inflammaging and immunosenescence"}, {"directness": "primary", "doi": "10.1016/j.jgr.2025.05.004", "risk_of_bias": "not appraised in public sidecar", "study": "Red ginseng extract enhances mitochondrial function and alleviates immunosenescence in T cells"}, {"directness": "primary", "doi": "10.3390/microorganisms12102052", "risk_of_bias": "not appraised in public sidecar", "study": "Immunosenescence: How Aging Increases Susceptibility to Bacterial Infections and Virulence Factors"}, {"directness": "primary", "doi": "10.3389/fragi.2024.1490302", "risk_of_bias": "not appraised in public sidecar", "study": "The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience"}, {"directness": "primary", "doi": "10.3390/ijms27031206", "risk_of_bias": "not appraised in public sidecar", "study": "Immunosenescence and Allergy: Molecular and Cellular Links Between Inflammaging, Neuro-Immune Aging, and Response to Biologic Therapies"}, {"directness": "primary", "doi": "10.1183/16000617.0248-2025", "risk_of_bias": "not appraised in public sidecar", "study": "Immunosenescence and susceptibility to respiratory viruses: a state-of-the-art review"}, {"directness": "primary", "doi": "10.3389/fragi.2025.1568034", "risk_of_bias": "not appraised in public sidecar", "study": "Multivariate analysis of immunosenescence data in healthy humans and diverse diseases"}, {"directness": "primary", "doi": "10.3389/fonc.2025.1567896", "risk_of_bias": "not appraised in public sidecar", "study": "Nanoparticle-mediated delivery of herbal-derived natural products to modulate immunosenescence-induced drug resistance in cancer therapy: a comprehensive review"}, {"directness": "primary", "doi": "10.3390/ijms26199268", "risk_of_bias": "not appraised in public sidecar", "study": "Rheumatoid Arthritis and Osteoporosis as Prototypes of Immunosenescence in Osteoimmunology: Molecular Pathways of Inflammaging and Targeted Therapies"}, {"directness": "primary", "doi": "10.3389/fimmu.2025.1660874", "risk_of_bias": "not appraised in public sidecar", "study": "Insights into tumor vaccines for elderly individuals in the context of immunosenescence"}, {"directness": "primary", "doi": "10.1002/cmdc.202400672", "risk_of_bias": "not appraised in public sidecar", "study": "Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges"}, {"directness": "primary", "doi": "10.1186/s12979-025-00549-1", "risk_of_bias": "not appraised in public sidecar", "study": "“Immunopause” no more: exercise to counter immunosenescence in aging"}, {"directness": "primary", "doi": "10.3389/fimmu.2024.1375730", "risk_of_bias": "not appraised in public sidecar", "study": "Impact and potential value of immunosenescence on solid gastrointestinal tumors"}, {"directness": "primary", "doi": "10.1186/s12979-024-00489-2", "risk_of_bias": "not appraised in public sidecar", "study": "The role of autoantibodies in bridging obesity, aging, and immunosenescence"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}
metadata
{
"researka_object_type": "publication_sidecar",
"researka_publication_id": "bd88fdac-646d-49da-ad47-a3e928cc057a",
"researka_submission_id": "6c9d2c5a-4a4e-489e-80e6-f51407ff1911",
"sidecar_name": "risk_of_bias.json",
"sidecar_url": "https://api.researka.org/publications/bd88fdac-646d-49da-ad47-a3e928cc057a/sidecars/risk_of_bias.json"
}