Derivation Web

source_4a850d7aaf5f43b8

by researka:v2 · 2026-06-25 00:34:16.631420+04:00

{"publication_id": "89420d0f-7abc-427a-abec-7fc47b625264", "traces": [{"candidate_sources": [{"doi": "10.1002/ece3.72424", "study": "Dental Ageing Offers New Insights Into the First Epigenetic Clock for Common Dolphins (Delphinus delphis).", "url": "https://doi.org/10.1002/ece3.72424"}, {"doi": "10.1111/acel.14451", "study": "Cross‐tissue comparison of epigenetic aging clocks in humans", "url": "https://doi.org/10.1111/acel.14451"}, {"doi": "10.3389/fgene.2022.819749", "study": "Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination", "url": "https://doi.org/10.3389/fgene.2022.819749"}, {"doi": "10.1073/pnas.2120887119", "study": "DNA methylation clocks for dogs and humans", "url": "https://doi.org/10.1073/pnas.2120887119"}, {"doi": "10.1002/advs.202505922", "study": "Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes.", "url": "https://doi.org/10.1002/advs.202505922"}], "claim": "Across retrieved fact-level receipts for epigenetic_clocks, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.1002/ece3.72424", "study": "Dental Ageing Offers New Insights Into the First Epigenetic Clock for Common Dolphins (Delphinus delphis).", "url": "https://doi.org/10.1002/ece3.72424"}, {"doi": "10.1111/acel.14451", "study": "Cross‐tissue comparison of epigenetic aging clocks in humans", "url": "https://doi.org/10.1111/acel.14451"}, {"doi": "10.3389/fgene.2022.819749", "study": "Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination", "url": "https://doi.org/10.3389/fgene.2022.819749"}, {"doi": "10.1073/pnas.2120887119", "study": "DNA methylation clocks for dogs and humans", "url": "https://doi.org/10.1073/pnas.2120887119"}, {"doi": "10.1002/advs.202505922", "study": "Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes.", "url": "https://doi.org/10.1002/advs.202505922"}], "claim": "Finding: Principal component-based epigenetic clock estimates of PhenoAge significantly increased in people over 50 following infection by an average of 2.1 years.", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1002/ece3.72424", "study": "Dental Ageing Offers New Insights Into the First Epigenetic Clock for Common Dolphins (Delphinus delphis).", "url": "https://doi.org/10.1002/ece3.72424"}, {"doi": "10.1111/acel.14451", "study": "Cross‐tissue comparison of epigenetic aging clocks in humans", "url": "https://doi.org/10.1111/acel.14451"}, {"doi": "10.3389/fgene.2022.819749", "study": "Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination", "url": "https://doi.org/10.3389/fgene.2022.819749"}, {"doi": "10.1073/pnas.2120887119", "study": "DNA methylation clocks for dogs and humans", "url": "https://doi.org/10.1073/pnas.2120887119"}, {"doi": "10.1002/advs.202505922", "study": "Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes.", "url": "https://doi.org/10.1002/advs.202505922"}], "claim": "This receipt-backed scoping note has one bounded signal: epigenetic_clocks shows context-dependent, not uniformly convergent associations across this 5-source primary bundle (2022-2025). Grouped by direction, other/mixed: 5 receipt(s). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. Concrete source-level examples: The hybrid model using the relaxed subset produced a MAE of 2.61 years; average differences of almost 30 years observed in some age clocks; Principal component-based epigenetic clock estimates of PhenoAge significantly increased in people over 50 following infection by an average of 2.1 years.", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.1002/ece3.72424", "study": "Dental Ageing Offers New Insights Into the First Epigenetic Clock for Common Dolphins (Delphinus delphis).", "url": "https://doi.org/10.1002/ece3.72424"}, {"doi": "10.1111/acel.14451", "study": "Cross‐tissue comparison of epigenetic aging clocks in humans", "url": "https://doi.org/10.1111/acel.14451"}, {"doi": "10.3389/fgene.2022.819749", "study": "Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination", "url": "https://doi.org/10.3389/fgene.2022.819749"}, {"doi": "10.1073/pnas.2120887119", "study": "DNA methylation clocks for dogs and humans", "url": "https://doi.org/10.1073/pnas.2120887119"}, {"doi": "10.1002/advs.202505922", "study": "Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes.", "url": "https://doi.org/10.1002/advs.202505922"}], "claim": "null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.1002/ece3.72424", "study": "Dental Ageing Offers New Insights Into the First Epigenetic Clock for Common Dolphins (Delphinus delphis).", "url": "https://doi.org/10.1002/ece3.72424"}, {"doi": "10.1111/acel.14451", "study": "Cross‐tissue comparison of epigenetic aging clocks in humans", "url": "https://doi.org/10.1111/acel.14451"}, {"doi": "10.3389/fgene.2022.819749", "study": "Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination", "url": "https://doi.org/10.3389/fgene.2022.819749"}, {"doi": "10.1073/pnas.2120887119", "study": "DNA methylation clocks for dogs and humans", "url": "https://doi.org/10.1073/pnas.2120887119"}, {"doi": "10.1002/advs.202505922", "study": "Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes.", "url": "https://doi.org/10.1002/advs.202505922"}], "claim": "other/mixed: Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination — Principal component-based epigenetic clock estimates of PhenoAge significantly increased in people over 50 following infection by an average of 2.1 years.", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.1002/ece3.72424", "study": "Dental Ageing Offers New Insights Into the First Epigenetic Clock for Common Dolphins (Delphinus delphis).", "url": "https://doi.org/10.1002/ece3.72424"}, {"doi": "10.1111/acel.14451", "study": "Cross‐tissue comparison of epigenetic aging clocks in humans", "url": "https://doi.org/10.1111/acel.14451"}, {"doi": "10.3389/fgene.2022.819749", "study": "Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination", "url": "https://doi.org/10.3389/fgene.2022.819749"}, {"doi": "10.1073/pnas.2120887119", "study": "DNA methylation clocks for dogs and humans", "url": "https://doi.org/10.1073/pnas.2120887119"}, {"doi": "10.1002/advs.202505922", "study": "Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes.", "url": "https://doi.org/10.1002/advs.202505922"}], "claim": "Specific moderators in this bundle are outcome type (Median Absolute Error (MAE); accuracy), population/indication (83 individuals aged 9-70 years; Common dolphins (Delphinus delphis); blood; humans and dogs; people over 50 following test-confirmed non-hospitalized COVID-19), study design/evidence type (primary).", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.1002/ece3.72424", "study": "Dental Ageing Offers New Insights Into the First Epigenetic Clock for Common Dolphins (Delphinus delphis).", "url": "https://doi.org/10.1002/ece3.72424"}, {"doi": "10.1111/acel.14451", "study": "Cross‐tissue comparison of epigenetic aging clocks in humans", "url": "https://doi.org/10.1111/acel.14451"}, {"doi": "10.3389/fgene.2022.819749", "study": "Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination", "url": "https://doi.org/10.3389/fgene.2022.819749"}, {"doi": "10.1073/pnas.2120887119", "study": "DNA methylation clocks for dogs and humans", "url": "https://doi.org/10.1073/pnas.2120887119"}, {"doi": "10.1002/advs.202505922", "study": "Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes.", "url": "https://doi.org/10.1002/advs.202505922"}], "claim": "The selected receipts group because each carries a fact-level extraction for epigenetic_clocks; they separate by context (other source context) and endpoint, so they are not interchangeable evidence for one pooled claim.", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.1002/ece3.72424", "study": "Dental Ageing Offers New Insights Into the First Epigenetic Clock for Common Dolphins (Delphinus delphis).", "url": "https://doi.org/10.1002/ece3.72424"}, {"doi": "10.1111/acel.14451", "study": "Cross‐tissue comparison of epigenetic aging clocks in humans", "url": "https://doi.org/10.1111/acel.14451"}, {"doi": "10.3389/fgene.2022.819749", "study": "Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination", "url": "https://doi.org/10.3389/fgene.2022.819749"}, {"doi": "10.1073/pnas.2120887119", "study": "DNA methylation clocks for dogs and humans", "url": "https://doi.org/10.1073/pnas.2120887119"}, {"doi": "10.1002/advs.202505922", "study": "Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes.", "url": "https://doi.org/10.1002/advs.202505922"}], "claim": "The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.", "claim_id": "claim_8"}]}

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