Derivation Web

source_4aa47c9ce4de4eca

by researka:v2 · 2026-06-03 06:07:58.567590+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "9e9f3163-3f3b-4c1f-9790-a8b1400b8696", "sources": [{"directness": "primary", "doi": "10.1186/s13148-023-01480-2", "risk_of_bias": "not appraised in public sidecar", "study": "Bozack 2023"}, {"directness": "primary", "doi": "10.1007/s11357-024-01138-8", "risk_of_bias": "not appraised in public sidecar", "study": "McGee 2024"}, {"directness": "primary", "doi": "10.1186/s12958-025-01429-5", "risk_of_bias": "not appraised in public sidecar", "study": "Marinello 2025"}, {"directness": "primary", "doi": "10.1186/s13148-021-01031-7", "risk_of_bias": "not appraised in public sidecar", "study": "Petersen 2021"}, {"directness": "primary", "doi": "10.1186/s13148-023-01484-y", "risk_of_bias": "not appraised in public sidecar", "study": "Arpawong 2023"}, {"directness": "primary", "doi": "10.1111/acel.70424", "risk_of_bias": "not appraised in public sidecar", "study": "Nguyen 2026"}, {"directness": "primary", "doi": "10.18632/aging.206221", "risk_of_bias": "not appraised in public sidecar", "study": "Carreras-Gallo 2025"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2024.27889", "risk_of_bias": "not appraised in public sidecar", "study": "Harris 2024"}, {"directness": "primary", "doi": "10.3389/fimmu.2024.1339722", "risk_of_bias": "not appraised in public sidecar", "study": "Tian 2024"}, {"directness": "primary", "doi": "10.1111/acel.13926", "risk_of_bias": "not appraised in public sidecar", "study": "Corley 2023"}, {"directness": "primary", "doi": "10.1080/15592294.2025.2530618", "risk_of_bias": "not appraised in public sidecar", "study": "Zhu 2025"}, {"directness": "primary", "doi": "10.1038/s43587-023-00462-6", "risk_of_bias": "not appraised in public sidecar", "study": "Lu 2023"}, {"directness": "primary", "doi": "10.1111/acer.70020", "risk_of_bias": "not appraised in public sidecar", "study": "Perlstein 2025"}, {"directness": "primary", "doi": "10.1111/acel.70103", "risk_of_bias": "not appraised in public sidecar", "study": "Fuentealba 2025"}, {"directness": "primary", "doi": "10.1111/1755-0998.70109", "risk_of_bias": "not appraised in public sidecar", "study": "Anastasiadi 2026"}, {"directness": "primary", "doi": "10.1002/dad2.70038", "risk_of_bias": "not appraised in public sidecar", "study": "Savin 2024"}, {"directness": "primary", "doi": "10.1093/brain/awaa334", "risk_of_bias": "not appraised in public sidecar", "study": "Shireby 2020"}, {"directness": "primary", "doi": "10.1186/s13148-021-01112-7", "risk_of_bias": "not appraised in public sidecar", "study": "Tiina 2021"}, {"directness": "primary", "doi": "10.1111/acel.70243", "risk_of_bias": "not appraised in public sidecar", "study": "Zhang 2025"}, {"directness": "primary", "doi": "10.1038/s43587-025-00883-5", "risk_of_bias": "not appraised in public sidecar", "study": "Fuentealba 2025b"}, {"directness": "primary", "doi": "10.1093/gerona/glab016", "risk_of_bias": "not appraised in public sidecar", "study": "Crimmins 2021"}, {"directness": "primary", "doi": "10.3389/fragi.2023.1258183", "risk_of_bias": "not appraised in public sidecar", "study": "Bienkowska 2024"}, {"directness": "primary", "doi": "10.1002/ece3.71424", "risk_of_bias": "not appraised in public sidecar", "study": "Shimozuru 2025"}, {"directness": "primary", "doi": "10.1093/gerona/glaf036", "risk_of_bias": "not appraised in public sidecar", "study": "Crimmins 2025"}, {"directness": "primary", "doi": "10.1007/s11357-021-00438-7", "risk_of_bias": "not appraised in public sidecar", "study": "Horvath 2021"}, {"directness": "primary", "doi": "10.18632/aging.206184", "risk_of_bias": "not appraised in public sidecar", "study": "Tong 2024"}, {"directness": "primary", "doi": "10.3390/genes16060679", "risk_of_bias": "not appraised in public sidecar", "study": "Cerantonio 2025"}, {"directness": "primary", "doi": "10.1038/s41514-022-00085-y", "risk_of_bias": "not appraised in public sidecar", "study": "Camillo 2022"}, {"directness": "primary", "doi": "10.1007/s11357-021-00439-6", "risk_of_bias": "not appraised in public sidecar", "study": "Schachtschneider 2021"}, {"directness": "primary", "doi": "10.1007/s11357-024-01086-3", "risk_of_bias": "not appraised in public sidecar", "study": "Pospiech 2024"}, {"directness": "primary", "doi": "10.3390/cells11244044", "risk_of_bias": "not appraised in public sidecar", "study": "Gensous 2022"}, {"directness": "primary", "doi": "10.1002/alz.083616", "risk_of_bias": "not appraised in public sidecar", "study": "Savin 2025"}, {"directness": "review-level", "doi": "10.3390/ijms24032254", "risk_of_bias": "not appraised in public sidecar", "study": "Paparazzo 2023"}, {"directness": "primary", "doi": "10.1186/s13041-021-00810-w", "risk_of_bias": "not appraised in public sidecar", "study": "Steg 2021"}, {"directness": "primary", "doi": "10.1111/acel.14071", "risk_of_bias": "not appraised in public sidecar", "study": "Zhang 2023"}, {"directness": "primary", "doi": "10.1111/eva.13195", "risk_of_bias": "not appraised in public sidecar", "study": "Bors 2021"}, {"directness": "review-level", "doi": "10.18632/aging.206098", "risk_of_bias": "not appraised in public sidecar", "study": "Warner 2024"}, {"directness": "primary", "doi": "10.1111/acel.13349", "risk_of_bias": "not appraised in public sidecar", "study": "Kordowitzki 2021"}, {"directness": "review-level", "doi": "10.1186/s13148-019-0656-7", "risk_of_bias": "not appraised in public sidecar", "study": "Fransquet 2019"}, {"directness": "primary", "doi": "10.1186/s13148-016-0186-5", "risk_of_bias": "not appraised in public sidecar", "study": "Breitling 2016"}, {"directness": "primary", "doi": "10.1186/s13059-017-1203-5", "risk_of_bias": "not appraised in public sidecar", "study": "Stubbs 2017"}, {"directness": "primary", "doi": "10.1093/infdis/jiv277", "risk_of_bias": "not appraised in public sidecar", "study": "Horvath 2015"}, {"directness": "primary", "doi": "10.1186/s13059-019-1810-4", "risk_of_bias": "not appraised in public sidecar", "study": "Khoury 2019"}, {"directness": "primary", "doi": "10.1038/s41398-018-0233-4", "risk_of_bias": "not appraised in public sidecar", "study": "Rosen 2018"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "9e9f3163-3f3b-4c1f-9790-a8b1400b8696",
  "researka_submission_id": "c3970068-614b-437f-8ae9-14771ee32227",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/9e9f3163-3f3b-4c1f-9790-a8b1400b8696/sidecars/risk_of_bias.json"
}