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sha256 bb1fd8733c499aa4166705a788f8a57b5eafbdefdfcfb69dd4b8835f158337c1
by researka:v2 · 2026-06-24 08:46:03.708148+04:00
{"publication_id": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "traces": [{"candidate_sources": [{"doi": "10.1093/ndt/gfad258", "study": "International consensus on post-transplantation diabetes mellitus", "url": "https://doi.org/10.1093/ndt/gfad258"}, {"doi": "10.1126/scitranslmed.3009892", "study": "mTOR inhibition improves immune function in the elderly", "url": "https://doi.org/10.1126/scitranslmed.3009892"}, {"doi": "10.1111/tri.12372", "study": "Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.", "url": "https://doi.org/10.1111/tri.12372"}, {"doi": "10.1016/j.celrep.2013.07.030", "study": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.", "url": "https://doi.org/10.1016/j.celrep.2013.07.030"}, {"doi": "10.1158/1940-6207.capr-10-0055", "study": "Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis", "url": "https://doi.org/10.1158/1940-6207.capr-10-0055"}], "claim": "Across retrieved fact-level receipts for mtor, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.1093/ndt/gfad258", "study": "International consensus on post-transplantation diabetes mellitus", "url": "https://doi.org/10.1093/ndt/gfad258"}, {"doi": "10.1126/scitranslmed.3009892", "study": "mTOR inhibition improves immune function in the elderly", "url": "https://doi.org/10.1126/scitranslmed.3009892"}, {"doi": "10.1111/tri.12372", "study": "Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.", "url": "https://doi.org/10.1111/tri.12372"}, {"doi": "10.1016/j.celrep.2013.07.030", "study": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.", "url": "https://doi.org/10.1016/j.celrep.2013.07.030"}, {"doi": "10.1158/1940-6207.capr-10-0055", "study": "Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis", "url": "https://doi.org/10.1158/1940-6207.capr-10-0055"}], "claim": "Finding: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1093/ndt/gfad258", "study": "International consensus on post-transplantation diabetes mellitus", "url": "https://doi.org/10.1093/ndt/gfad258"}, {"doi": "10.1126/scitranslmed.3009892", "study": "mTOR inhibition improves immune function in the elderly", "url": "https://doi.org/10.1126/scitranslmed.3009892"}, {"doi": "10.1111/tri.12372", "study": "Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.", "url": "https://doi.org/10.1111/tri.12372"}, {"doi": "10.1016/j.celrep.2013.07.030", "study": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.", "url": "https://doi.org/10.1016/j.celrep.2013.07.030"}, {"doi": "10.1158/1940-6207.capr-10-0055", "study": "Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis", "url": "https://doi.org/10.1158/1940-6207.capr-10-0055"}], "claim": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. [primary; 2013] doi:10.1016/j.celrep.2013.07.030", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.1093/ndt/gfad258", "study": "International consensus on post-transplantation diabetes mellitus", "url": "https://doi.org/10.1093/ndt/gfad258"}, {"doi": "10.1126/scitranslmed.3009892", "study": "mTOR inhibition improves immune function in the elderly", "url": "https://doi.org/10.1126/scitranslmed.3009892"}, {"doi": "10.1111/tri.12372", "study": "Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.", "url": "https://doi.org/10.1111/tri.12372"}, {"doi": "10.1016/j.celrep.2013.07.030", "study": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.", "url": "https://doi.org/10.1016/j.celrep.2013.07.030"}, {"doi": "10.1158/1940-6207.capr-10-0055", "study": "Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis", "url": "https://doi.org/10.1158/1940-6207.capr-10-0055"}], "claim": "Finding: Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition of mTOR in tumors.", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.1093/ndt/gfad258", "study": "International consensus on post-transplantation diabetes mellitus", "url": "https://doi.org/10.1093/ndt/gfad258"}, {"doi": "10.1126/scitranslmed.3009892", "study": "mTOR inhibition improves immune function in the elderly", "url": "https://doi.org/10.1126/scitranslmed.3009892"}, {"doi": "10.1111/tri.12372", "study": "Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.", "url": "https://doi.org/10.1111/tri.12372"}, {"doi": "10.1016/j.celrep.2013.07.030", "study": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.", "url": "https://doi.org/10.1016/j.celrep.2013.07.030"}, {"doi": "10.1158/1940-6207.capr-10-0055", "study": "Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis", "url": "https://doi.org/10.1158/1940-6207.capr-10-0055"}], "claim": "This receipt-backed scoping note has one bounded signal: mtor shows context-dependent, not convergent, associations across this 5-source primary/review bundle (2010-2024). Grouped by direction, directionally favorable: RAD001 improved influenza vaccine response by ~20% in the elderly; Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition... | other/mixed: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P =...; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. Concrete source-level examples: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10; RAD001 improved influenza vaccine response by ~20% in the elderly; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%).", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.1093/ndt/gfad258", "study": "International consensus on post-transplantation diabetes mellitus", "url": "https://doi.org/10.1093/ndt/gfad258"}, {"doi": "10.1126/scitranslmed.3009892", "study": "mTOR inhibition improves immune function in the elderly", "url": "https://doi.org/10.1126/scitranslmed.3009892"}, {"doi": "10.1111/tri.12372", "study": "Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.", "url": "https://doi.org/10.1111/tri.12372"}, {"doi": "10.1016/j.celrep.2013.07.030", "study": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.", "url": "https://doi.org/10.1016/j.celrep.2013.07.030"}, {"doi": "10.1158/1940-6207.capr-10-0055", "study": "Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis", "url": "https://doi.org/10.1158/1940-6207.capr-10-0055"}], "claim": "other/mixed: International consensus on post-transplantation diabetes mellitus — observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.1093/ndt/gfad258", "study": "International consensus on post-transplantation diabetes mellitus", "url": "https://doi.org/10.1093/ndt/gfad258"}, {"doi": "10.1126/scitranslmed.3009892", "study": "mTOR inhibition improves immune function in the elderly", "url": "https://doi.org/10.1126/scitranslmed.3009892"}, {"doi": "10.1111/tri.12372", "study": "Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.", "url": "https://doi.org/10.1111/tri.12372"}, {"doi": "10.1016/j.celrep.2013.07.030", "study": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.", "url": "https://doi.org/10.1016/j.celrep.2013.07.030"}, {"doi": "10.1158/1940-6207.capr-10-0055", "study": "Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis", "url": "https://doi.org/10.1158/1940-6207.capr-10-0055"}], "claim": "other/mixed: Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. — exhibit an approximately 20% increase in median survival.", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.1093/ndt/gfad258", "study": "International consensus on post-transplantation diabetes mellitus", "url": "https://doi.org/10.1093/ndt/gfad258"}, {"doi": "10.1126/scitranslmed.3009892", "study": "mTOR inhibition improves immune function in the elderly", "url": "https://doi.org/10.1126/scitranslmed.3009892"}, {"doi": "10.1111/tri.12372", "study": "Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.", "url": "https://doi.org/10.1111/tri.12372"}, {"doi": "10.1016/j.celrep.2013.07.030", "study": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.", "url": "https://doi.org/10.1016/j.celrep.2013.07.030"}, {"doi": "10.1158/1940-6207.capr-10-0055", "study": "Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis", "url": "https://doi.org/10.1158/1940-6207.capr-10-0055"}], "claim": "directionally favorable: Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis — Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition of mTOR in tumors.", "claim_id": "claim_8"}, {"candidate_sources": [{"doi": "10.1093/ndt/gfad258", "study": "International consensus on post-transplantation diabetes mellitus", "url": "https://doi.org/10.1093/ndt/gfad258"}, {"doi": "10.1126/scitranslmed.3009892", "study": "mTOR inhibition improves immune function in the elderly", "url": "https://doi.org/10.1126/scitranslmed.3009892"}, {"doi": "10.1111/tri.12372", "study": "Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.", "url": "https://doi.org/10.1111/tri.12372"}, {"doi": "10.1016/j.celrep.2013.07.030", "study": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.", "url": "https://doi.org/10.1016/j.celrep.2013.07.030"}, {"doi": "10.1158/1940-6207.capr-10-0055", "study": "Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis", "url": "https://doi.org/10.1158/1940-6207.capr-10-0055"}], "claim": "Candidate moderators are population or indication, endpoint, comparator, and study design/evidence type; these dimensions explain why the receipts should be read as divergent evidence fronts, not one pooled effect.", "claim_id": "claim_9"}, {"candidate_sources": [{"doi": "10.1093/ndt/gfad258", "study": "International consensus on post-transplantation diabetes mellitus", "url": "https://doi.org/10.1093/ndt/gfad258"}, {"doi": "10.1126/scitranslmed.3009892", "study": "mTOR inhibition improves immune function in the elderly", "url": "https://doi.org/10.1126/scitranslmed.3009892"}, {"doi": "10.1111/tri.12372", "study": "Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.", "url": "https://doi.org/10.1111/tri.12372"}, {"doi": "10.1016/j.celrep.2013.07.030", "study": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.", "url": "https://doi.org/10.1016/j.celrep.2013.07.030"}, {"doi": "10.1158/1940-6207.capr-10-0055", "study": "Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis", "url": "https://doi.org/10.1158/1940-6207.capr-10-0055"}], "claim": "The selected receipts group because each carries a fact-level extraction for mtor; they separate by context (animal model, human clinical/observational, and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim.", "claim_id": "claim_10"}, {"candidate_sources": [{"doi": "10.1093/ndt/gfad258", "study": "International consensus on post-transplantation diabetes mellitus", "url": "https://doi.org/10.1093/ndt/gfad258"}, {"doi": "10.1126/scitranslmed.3009892", "study": "mTOR inhibition improves immune function in the elderly", "url": "https://doi.org/10.1126/scitranslmed.3009892"}, {"doi": "10.1111/tri.12372", "study": "Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.", "url": "https://doi.org/10.1111/tri.12372"}, {"doi": "10.1016/j.celrep.2013.07.030", "study": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.", "url": "https://doi.org/10.1016/j.celrep.2013.07.030"}, {"doi": "10.1158/1940-6207.capr-10-0055", "study": "Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis", "url": "https://doi.org/10.1158/1940-6207.capr-10-0055"}], "claim": "Source-literature boundary for mtor: the listed sources define separate evidence fronts. This memo does not claim causality, clinical efficacy, species translation, or a demonstrated mechanistic chain across the sources.", "claim_id": "claim_11"}, {"candidate_sources": [{"doi": "10.1093/ndt/gfad258", "study": "International consensus on post-transplantation diabetes mellitus", "url": "https://doi.org/10.1093/ndt/gfad258"}, {"doi": "10.1126/scitranslmed.3009892", "study": "mTOR inhibition improves immune function in the elderly", "url": "https://doi.org/10.1126/scitranslmed.3009892"}, {"doi": "10.1111/tri.12372", "study": "Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.", "url": "https://doi.org/10.1111/tri.12372"}, {"doi": "10.1016/j.celrep.2013.07.030", "study": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.", "url": "https://doi.org/10.1016/j.celrep.2013.07.030"}, {"doi": "10.1158/1940-6207.capr-10-0055", "study": "Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis", "url": "https://doi.org/10.1158/1940-6207.capr-10-0055"}], "claim": "The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.", "claim_id": "claim_12"}]}
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