Derivation Web

source_4e214b1311e54acd

by researka:v2 · 2026-07-04 17:39:59.934983+04:00

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Evidence role grouping: direction-bearing receipts: 3; null/mixed metric-scope caveat receipts: 0; context/antecedent/model receipts: 2 excluded from effect support. The source facts cover 5 population/setting context(s) and 3 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. This is a heterogeneous indication/context map, not a unified disease-specific or endpoint-family claim. Concrete contrast: other/mixed: Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging: acarbose and 17-α estradiol do not strongly alter these phenotypes; directionally favorable: Acarbose improves health and lifespan in aging HET3 mice: significantly increased (3%) in females only at 1,000 ppm.", "type": "claim"}, {"id": "claim_9", "text": "null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.", "type": "claim"}, {"id": "claim_10", "text": "directionally favorable: Acarbose improves health and lifespan in aging HET3 mice — significantly increased (3%) in females only at 1,000 ppm", "type": "claim"}, {"id": "claim_11", "text": "directionally favorable: Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats — acarbose produced 51% decrease in maltose loaded diabetic rats", "type": "claim"}, {"id": "claim_12", "text": "directionally favorable: Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats. — 8-week treatment with acarbose significantly decreased fasting blood glucose.", "type": "claim"}, {"id": "claim_13", "text": "Evidence role summary: direction-bearing receipts: 3; null/mixed metric-scope caveat receipts: 0; context/antecedent/model receipts: 2 excluded from effect support.", "type": "claim"}, {"id": "claim_14", "text": "Specific moderators in this bundle are population/indication (HET3 mice; diabetic rats; female mice; maltose loaded diabetic rats; mice fed high-starch diet), study design/evidence type (primary).", "type": "claim"}, {"id": "claim_15", "text": "Population/settings are separated as receipt context: HET3 mice, diabetic rats, female mice, maltose loaded diabetic rats, and mice fed high-starch diet. The selected receipts group because each carries a fact-level extraction for acarbose; they separate by context (animal model) and endpoint, so they are not interchangeable evidence for one pooled claim.", "type": "claim"}, {"id": "claim_16", "text": "The signal is purely descriptive of source-level direction and scope; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.12898", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "acarbose at 1000 ppm", "population": "female mice", "risk_of_bias": "not appraised in public sidecar", "study": "Acarbose improves health and lifespan in aging HET3 mice", "type": "source", "url": "https://doi.org/10.1111/acel.12898", "year": 2019}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1093/gerona/glz177", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "acarbose", "population": "HET3 mice", "risk_of_bias": "not appraised in public sidecar", "study": "Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging", "type": "source", "url": "https://doi.org/10.1093/gerona/glz177", "year": 2019}, {"comparator": "not extracted", "directness": "primary", "doi": "10.4236/jdm.2012.21013", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "acarbose", "population": "maltose loaded diabetic rats", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "type": "source", "url": "https://doi.org/10.4236/jdm.2012.21013", "year": 2012}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1128/msphere.00528-18", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "acarbose at 400 ppm", "population": "mice fed high-starch diet", "risk_of_bias": "not appraised in public sidecar", "study": "The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome", "type": "source", "url": "https://doi.org/10.1128/msphere.00528-18", "year": 2019}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1371/journal.pone.0079697", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "acarbose", "population": "diabetic rats", "risk_of_bias": "not appraised in public sidecar", "study": "Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.", "type": "source", "url": "https://doi.org/10.1371/journal.pone.0079697", "year": 2013}], "publication_id": "bde27e52-8cfd-4e9f-8721-e899352f3a58", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 5, "included": 5, "included_or_retained": 5, "screened": 5, "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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