source · application/json
source_4e7bd2ebfc4a4528
sha256 3772738071015fd4f0009bcef9102e2ce054304c83ea6c869e11a86a5bb42342
by researka:v2 · 2026-06-26 07:04:31.844076+04:00
{"publication_id": "62430fb3-2826-496e-a45c-494e9acdb5ba", "traces": [{"candidate_sources": [{"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": "https://doi.org/10.3389/fmed.2021.640785"}, {"doi": "10.1172/jci.insight.133247", "study": "Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer", "url": "https://doi.org/10.1172/jci.insight.133247"}, {"doi": "10.1016/j.dsx.2020.11.006", "study": "The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis", "url": "https://doi.org/10.1016/j.dsx.2020.11.006"}, {"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": "https://doi.org/10.1002/ijc.31783"}, {"doi": "10.1158/1940-6207.capr-13-0424", "study": "Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders", "url": "https://doi.org/10.1158/1940-6207.capr-13-0424"}], "claim": "Across retrieved source-level receipts for metformin_longevity, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": "https://doi.org/10.3389/fmed.2021.640785"}, {"doi": "10.1172/jci.insight.133247", "study": "Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer", "url": "https://doi.org/10.1172/jci.insight.133247"}, {"doi": "10.1016/j.dsx.2020.11.006", "study": "The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis", "url": "https://doi.org/10.1016/j.dsx.2020.11.006"}, {"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": "https://doi.org/10.1002/ijc.31783"}, {"doi": "10.1158/1940-6207.capr-13-0424", "study": "Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders", "url": "https://doi.org/10.1158/1940-6207.capr-13-0424"}], "claim": "Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders [review; 2014] doi:10.1158/1940-6207.capr-13-0424", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": "https://doi.org/10.3389/fmed.2021.640785"}, {"doi": "10.1172/jci.insight.133247", "study": "Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer", "url": "https://doi.org/10.1172/jci.insight.133247"}, {"doi": "10.1016/j.dsx.2020.11.006", "study": "The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis", "url": "https://doi.org/10.1016/j.dsx.2020.11.006"}, {"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": "https://doi.org/10.1002/ijc.31783"}, {"doi": "10.1158/1940-6207.capr-13-0424", "study": "Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders", "url": "https://doi.org/10.1158/1940-6207.capr-13-0424"}], "claim": "Finding: Overall cancer incidence was reduced by 31% [summary relative risk (SRR), 0.69; 95% confidence interval (CI), 0.52-0.90]", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": "https://doi.org/10.3389/fmed.2021.640785"}, {"doi": "10.1172/jci.insight.133247", "study": "Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer", "url": "https://doi.org/10.1172/jci.insight.133247"}, {"doi": "10.1016/j.dsx.2020.11.006", "study": "The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis", "url": "https://doi.org/10.1016/j.dsx.2020.11.006"}, {"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": "https://doi.org/10.1002/ijc.31783"}, {"doi": "10.1158/1940-6207.capr-13-0424", "study": "Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders", "url": "https://doi.org/10.1158/1940-6207.capr-13-0424"}], "claim": "null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": "https://doi.org/10.3389/fmed.2021.640785"}, {"doi": "10.1172/jci.insight.133247", "study": "Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer", "url": "https://doi.org/10.1172/jci.insight.133247"}, {"doi": "10.1016/j.dsx.2020.11.006", "study": "The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis", "url": "https://doi.org/10.1016/j.dsx.2020.11.006"}, {"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": "https://doi.org/10.1002/ijc.31783"}, {"doi": "10.1158/1940-6207.capr-13-0424", "study": "Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders", "url": "https://doi.org/10.1158/1940-6207.capr-13-0424"}], "claim": "directionally favorable: Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders — Overall cancer incidence was reduced by 31% [summary relative risk (SRR), 0.69; 95% confidence interval (CI), 0.52-0.90]", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": "https://doi.org/10.3389/fmed.2021.640785"}, {"doi": "10.1172/jci.insight.133247", "study": "Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer", "url": "https://doi.org/10.1172/jci.insight.133247"}, {"doi": "10.1016/j.dsx.2020.11.006", "study": "The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis", "url": "https://doi.org/10.1016/j.dsx.2020.11.006"}, {"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": "https://doi.org/10.1002/ijc.31783"}, {"doi": "10.1158/1940-6207.capr-13-0424", "study": "Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders", "url": "https://doi.org/10.1158/1940-6207.capr-13-0424"}], "claim": "Specific moderators in this bundle are population/indication (hospitalized adult COVID-19 patients; nondiabetic patients with advanced-stage epithelial ovarian cancer; patients with WHO grade III glioma (high-grade glioma); patients with diabetes; sepsis patients with type 2 diabetes), study design/evidence type (primary/review). Single primary-study estimates are separated from pooled review or meta-analytic estimates rather than treated as interchangeable.", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": "https://doi.org/10.3389/fmed.2021.640785"}, {"doi": "10.1172/jci.insight.133247", "study": "Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer", "url": "https://doi.org/10.1172/jci.insight.133247"}, {"doi": "10.1016/j.dsx.2020.11.006", "study": "The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis", "url": "https://doi.org/10.1016/j.dsx.2020.11.006"}, {"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": "https://doi.org/10.1002/ijc.31783"}, {"doi": "10.1158/1940-6207.capr-13-0424", "study": "Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders", "url": "https://doi.org/10.1158/1940-6207.capr-13-0424"}], "claim": "The selected receipts group because each carries a fact-level extraction for metformin_longevity; they separate by context (human clinical/observational) and endpoint, so they are not interchangeable evidence for one pooled claim.", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": "https://doi.org/10.3389/fmed.2021.640785"}, {"doi": "10.1172/jci.insight.133247", "study": "Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer", "url": "https://doi.org/10.1172/jci.insight.133247"}, {"doi": "10.1016/j.dsx.2020.11.006", "study": "The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis", "url": "https://doi.org/10.1016/j.dsx.2020.11.006"}, {"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": "https://doi.org/10.1002/ijc.31783"}, {"doi": "10.1158/1940-6207.capr-13-0424", "study": "Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders", "url": "https://doi.org/10.1158/1940-6207.capr-13-0424"}], "claim": "The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.", "claim_id": "claim_8"}]}
metadata
{
"researka_object_type": "publication_sidecar",
"researka_publication_id": "62430fb3-2826-496e-a45c-494e9acdb5ba",
"researka_submission_id": "3eba19c0-77bc-4953-a15f-2d1cff119012",
"sidecar_name": "citation_traces.json",
"sidecar_url": "https://api.researka.org/publications/62430fb3-2826-496e-a45c-494e9acdb5ba/sidecars/citation_traces.json"
}