Derivation Web

source_4f63b4326dd04409

by researka:v2 · 2026-06-22 18:18:43.014870+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The sirtuin family in health and disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Impact of Dietary Modifications on Plasma Sirtuins 1, 3 and 5 in Older Overweight Individuals Undergoing 12-Weeks of Circuit Training",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
p53/sirtuin 1/NF-κB Signaling Axis in Chronic Inflammation and Maladaptive Kidney Repair After Cisplatin Nephrotoxicity,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Changes in the Systemic Expression of Sirtuin-1 and Oxidative Stress after Intravitreal Anti-Vascular Endothelial Growth Factor in Patients with Retinal Vein Occlusion,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Taurine, Sirtuin-1 and TNF- α levels in different aged adults with periodontitis: a pilot study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sirtuin 3 Dependent and Independent Effects of NAD + to Suppress Vascular Inflammation and Improve Endothelial Function in Mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Deciphering the Role of Sirtuin‐1 Gene Polymorphism in Diabetic Nephropathy: A Systematic Review and Meta‐Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Sirtuin 2 knockdown inhibits cell proliferation and RAS/ERK signaling, and promotes cell apoptosis and cell cycle arrest in multiple myeloma",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effects of perinatal factors on sirtuin 3, 8-hydroxy-2′- deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an observational study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Evaluation of sirtuin 1 as a predictor of cardiovascular outcomes in diabetic patients with limb-threatening ischemia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Studenski 2011,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cruz-Jentoft 2019,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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