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# Alpha memo: metformin exercise protocol mismatch **One-sentence alpha:** Receipt 1 suggests an additive insulin-secretion signal in prediabetes while Receipt 2 updates that the same metformin-exercise pairing splits by modality and may attenuate rather than enhance glycaemic effects in type 2 diabetes. **Receipt 1:** Konopka et al. 2010 MSSE conference abstract (DOI 10.1249/01.mss.0000389387.87…
sha256 380bef831818f8da…