Derivation Web

source_520d7698c4874ccc

by researka:v2 · 2026-06-28 04:45:41.808270+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "054f72de-a886-4506-a529-11d92344f009", "sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "risk_of_bias": "not appraised in public sidecar", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "risk_of_bias": "not appraised in public sidecar", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study"}, {"directness": "primary", "doi": "10.3390/nu16172963", "risk_of_bias": "not appraised in public sidecar", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "risk_of_bias": "not appraised in public sidecar", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "risk_of_bias": "not appraised in public sidecar", "study": "Systematic review of Mendelian randomization studies on risk of cancer"}, {"directness": "primary", "doi": "10.1038/s41514-026-00352-2", "risk_of_bias": "not appraised in public sidecar", "study": "Aging and increased cancer risk: exploring the potential of LE8 score to mitigate risk"}, {"directness": "primary", "doi": "10.1182/blood.2025031287", "risk_of_bias": "not appraised in public sidecar", "study": "Lymphoid malignancy and clonality in the POT1-mediated long telomere syndrome ∗"}, {"directness": "primary", "doi": "10.1038/s41598-026-36205-x", "risk_of_bias": "not appraised in public sidecar", "study": "Leukocyte telomere attrition following radiotherapy in prostate cancer: a prospective study"}, {"directness": "primary", "doi": "10.1177/15347354231154267", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of Traditional Korean Medicine Oncotherapy on the Survival, Quality of Life, and Telomere Length: A Prospective Cohort Study"}, {"directness": "primary", "doi": "10.1186/s10020-026-01423-6", "risk_of_bias": "not appraised in public sidecar", "study": "Unraveling the telomere-mitochondrial axis in colorectal cancer: Results from a prospectively followed cohort"}, {"directness": "primary", "doi": "10.1155/ijog/5301600", "risk_of_bias": "not appraised in public sidecar", "study": "Integrative Analysis of Telomere‐Related Genes Reveals Prognostic Signatures in Laryngeal Cancer"}, {"directness": "primary", "doi": "10.3390/cancers18030490", "risk_of_bias": "not appraised in public sidecar", "study": "Leukocyte Telomere Length Variants Are Independently Associated with Survival of Patients with Colorectal Cancer"}, {"directness": "primary", "doi": "10.1111/acel.14174", "risk_of_bias": "not appraised in public sidecar", "study": "DNA methylation‐based telomere length is associated with HIV infection, physical frailty, cancer, and all‐cause mortality"}, {"directness": "primary", "doi": "10.1186/s12885-023-11387-z", "risk_of_bias": "not appraised in public sidecar", "study": "Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India"}, {"directness": "primary", "doi": "10.1093/neuonc/noaf300", "risk_of_bias": "not appraised in public sidecar", "study": "SMARCAL1 is a targetable synthetic lethal therapeutic vulnerability in ATRX-deficient gliomas that use alternative lengthening of telomeres"}, {"directness": "review-level", "doi": "10.1111/acel.13874", "risk_of_bias": "not appraised in public sidecar", "study": "Association between genetically determined telomere length and health‐related outcomes: A systematic review and meta‐analysis of Mendelian randomization studies"}, {"directness": "review-level", "doi": "10.3390/curroncol33020074", "risk_of_bias": "not appraised in public sidecar", "study": "Telomerase Activity in Melanoma: Impact on Cancer Cell Proliferation Kinetics, Tumor Progression, and Clinical Therapeutic Strategies—A Scoping Review"}, {"directness": "primary", "doi": "10.3390/cancers18030499", "risk_of_bias": "not appraised in public sidecar", "study": "ZEB1 Promotes Alternate Lengthening of Telomeres at Multiple Levels"}, {"directness": "primary", "doi": "10.1371/journal.pone.0286219", "risk_of_bias": "not appraised in public sidecar", "study": "Mendelian randomization study on the causal relationship between leukocyte telomere length and prostate cancer"}, {"directness": "review-level", "doi": "10.3390/ijms25169000", "risk_of_bias": "not appraised in public sidecar", "study": "The Association between Telomere Length and Head and Neck Cancer Risk: A Systematic Review and Meta-Analysis"}, {"directness": "primary", "doi": "10.3389/fgene.2022.931785", "risk_of_bias": "not appraised in public sidecar", "study": "Association Between Telomere Length and Skin Cancer and Aging: A Mendelian Randomization Analysis"}, {"directness": "primary", "doi": "10.7150/jca.129718", "risk_of_bias": "not appraised in public sidecar", "study": "Integrative Bulk and Single-Cell Transcriptome Profiling of Telomere-Related Genes Reveals a Robust Prognostic Signature and Immunotherapeutic Landscape in Neuroblastoma"}, {"directness": "primary", "doi": "10.3389/fcell.2026.1797677", "risk_of_bias": "not appraised in public sidecar", "study": "Telomere-driven dysfunctional changes in gynecological cancers: mechanistic insights, biomarker potential, and therapeutic targeting"}, {"directness": "primary", "doi": "10.3389/fimmu.2024.1452946", "risk_of_bias": "not appraised in public sidecar", "study": "Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer"}, {"directness": "primary", "doi": "10.18632/oncotarget.8796", "risk_of_bias": "not appraised in public sidecar", "study": "The impact of adjuvant chemotherapy in older breast cancer patients on clinical and biological aging parameters"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "054f72de-a886-4506-a529-11d92344f009",
  "researka_submission_id": "19b5cfab-fd54-492f-86d2-e1f396814be5",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/054f72de-a886-4506-a529-11d92344f009/sidecars/risk_of_bias.json"
}