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source_523f23b384874bc3

sha256 06e2020df83a5956d1ec398ae78a5db640e7425d7837d2c6bb6405ece22cdcce

by researka:v2 · 2026-06-22 08:30:13.627821+04:00

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"Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy"}, {"directness": "primary", "doi": "10.1093/g3journal/jkab293", "risk_of_bias": "not appraised in public sidecar", "study": "A systems approach using Diversity Outbred mice distinguishes the cardiovascular effects and genetics of circulating GDF11 from those of its homolog, myostatin"}, {"directness": "primary", "doi": "10.1038/s41436-021-01216-8", "risk_of_bias": "not appraised in public sidecar", "study": "Heterozygous loss-of-function variants significantly expand the phenotypes associated with loss of GDF11"}, {"directness": "primary", "doi": "10.3892/etm.2024.12540", "risk_of_bias": "not appraised in public sidecar", "study": "GDF11 inhibits the malignant progression of hepatocellular carcinoma via regulation of the mTORC1‑autophagy axis"}, {"directness": "primary", "doi": "10.1093/tas/txad029", "risk_of_bias": "not appraised in public sidecar", "study": "Association of a variant 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A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1001/jama.2010.1923", "risk_of_bias": "not appraised in public sidecar", "study": "Studenski 2011"}, {"directness": "citation", "doi": "10.1111/j.1532-5415.2006.00701.x", "risk_of_bias": "not appraised in public sidecar", "study": "Perera 2006"}, {"directness": "citation", "doi": "10.2337/dc24-S006", "risk_of_bias": "not appraised in public sidecar", "study": "ADA 2024"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "WHO 2000"}, {"directness": "citation", "doi": "10.1093/ageing/afy169", "risk_of_bias": "not appraised in public sidecar", "study": "Cruz-Jentoft 2019"}]}
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