Derivation Web

source_52e16761e17e46b9

by researka:v2 · 2026-06-25 05:41:09.268051+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "2bd9802d-ec9a-4e3b-b941-43a68cda6945", "sources": [{"directness": "primary", "doi": "10.1113/EP093162", "risk_of_bias": "not appraised in public sidecar", "study": "Acute systemic and energy metabolism responses to velocity‐based resistance training following an oral glucose load in individuals with excess body weight"}, {"directness": "primary", "doi": "10.1186/s12916-025-04276-8", "risk_of_bias": "not appraised in public sidecar", "study": "Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction"}, {"directness": "primary", "doi": "10.1038/s41598-021-93214-8", "risk_of_bias": "not appraised in public sidecar", "study": "Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults"}, {"directness": "primary", "doi": "10.2196/46385", "risk_of_bias": "not appraised in public sidecar", "study": "The Effect of Sleep on Metabolism, Musculoskeletal Disease, and Mortality in the General US Population: Analysis of Results From the National Health and Nutrition Examination Survey"}, {"directness": "primary", "doi": "10.1002/alz.70984", "risk_of_bias": "not appraised in public sidecar", "study": "Acute effects of lactate infusion on metabolism, AD biomarkers, and cognition: The LEAN study"}, {"directness": "primary", "doi": "10.1097/MD.0000000000030049", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of resveratrol therapy on glucose metabolism, insulin resistance, inflammation, and renal function in the elderly patients with type 2 diabetes mellitus: A randomized controlled clinical trial protocol"}, {"directness": "primary", "doi": "10.1097/MD.0000000000039348", "risk_of_bias": "not appraised in public sidecar", "study": "Association of serum iron metabolism with muscle mass and frailty in older adults: A cross-sectional study of community-dwelling older adults"}, {"directness": "primary", "doi": "10.3389/fbioe.2021.622175", "risk_of_bias": "not appraised in public sidecar", "study": "Chlorpyrifos Disrupts Acetylcholine Metabolism Across Model Blood-Brain Barrier"}, {"directness": "primary", "doi": "10.1186/s12933-025-02920-4", "risk_of_bias": "not appraised in public sidecar", "study": "Dual modulation of lipid and glucose metabolism by a nutraceutical combination in patients at cardiometabolic risk: results from a multicenter randomized controlled trial"}, {"directness": "primary", "doi": "10.3390/nu16050653", "risk_of_bias": "not appraised in public sidecar", "study": "High-Density Lipoprotein Metabolism and Function in Cardiovascular Diseases: What about Aging and Diet Effects?"}, {"directness": "primary", "doi": "10.3389/fphys.2020.00147", "risk_of_bias": "not appraised in public sidecar", "study": "2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia"}, {"directness": "primary", "doi": "10.3389/fcvm.2025.1625064", "risk_of_bias": "not appraised in public sidecar", "study": "Identification of arachidonic acid metabolism-related diagnostic markers in heart failure based on bioinformatics analysis and machine learning"}, {"directness": "primary", "doi": "10.1111/acel.12251", "risk_of_bias": "not appraised in public sidecar", "study": "Metabolites related to gut bacterial metabolism, peroxisome proliferator-activated receptor-alpha activation, and insulin sensitivity are associated with physical function in functionally-limited older adults"}, {"directness": "primary", "doi": "10.1371/journal.pone.0119882", "risk_of_bias": "not appraised in public sidecar", "study": "Impaired Glucose Metabolism among Those with and without Diagnosed Diabetes and Mortality: A Cohort Study Using Health Survey for England Data"}, {"directness": "primary", "doi": "10.1111/acel.13048", "risk_of_bias": "not appraised in public sidecar", "study": "The role of lipid metabolism in aging, lifespan regulation, and age‐related disease"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1001/jama.2010.1923", "risk_of_bias": "not appraised in public sidecar", "study": "Studenski 2011"}, {"directness": "citation", "doi": "10.1111/j.1532-5415.2006.00701.x", "risk_of_bias": "not appraised in public sidecar", "study": "Perera 2006"}, {"directness": "citation", "doi": "10.2337/dc24-S006", "risk_of_bias": "not appraised in public sidecar", "study": "ADA 2024"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "WHO 2000"}, {"directness": "citation", "doi": "10.1093/ageing/afy169", "risk_of_bias": "not appraised in public sidecar", "study": "Cruz-Jentoft 2019"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "2bd9802d-ec9a-4e3b-b941-43a68cda6945",
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  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/2bd9802d-ec9a-4e3b-b941-43a68cda6945/sidecars/risk_of_bias.json"
}