Derivation Web

source_536df942ca054354

by researka:v2 · 2026-06-05 10:14:38.842497+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "c1cbca14-3224-46cc-bd1f-bc4a92a69d25", "sources": [{"directness": "primary", "doi": "10.1007/s00394-022-03038-z", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D supplementation and exercise for improving physical function, body composition and metabolic health in overweight or obese older adults with vitamin D deficiency: a pilot randomized, double-blind, placebo-controlled trial"}, {"directness": "primary", "doi": "10.3389/fendo.2023.1163671", "risk_of_bias": "not appraised in public sidecar", "study": "The association between vitamin D supplementation and the long-term prognosis of differentiated thyroid cancer patients: a retrospective observational cohort study with propensity score matching"}, {"directness": "primary", "doi": "10.1038/s41467-025-58721-6", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D supplementation vs. placebo and incident type 2 diabetes in an ancillary study of the randomized Vitamin D and Omega-3 Trial"}, {"directness": "review-level", "doi": "10.1002/jcsm.12976", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of vitamin D monotherapy on indices of sarcopenia in community‐dwelling older adults: a systematic review and meta‐analysis"}, {"directness": "review-level", "doi": "10.1136/bmj-2025-087438", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial"}, {"directness": "primary", "doi": "10.1186/s12877-022-02888-w", "risk_of_bias": "not appraised in public sidecar", "study": "The effects of vitamin D supplementation on frailty in older adults at risk for falls"}, {"directness": "primary", "doi": "10.3390/ijms24108567", "risk_of_bias": "not appraised in public sidecar", "study": "Potential Modulation of Inflammation and Physical Function by Combined Probiotics, Omega-3 Supplementation and Vitamin D Supplementation in Overweight/Obese Patients with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial"}, {"directness": "review-level", "doi": "10.1186/s12887-025-05795-2", "risk_of_bias": "not appraised in public sidecar", "study": "Can vitamin D supplementation affect cardiometabolic factors in children and adolescence with overweight and obesity? A grade-assessed systematic review and meta-analysis of randomized controlled trials"}, {"directness": "review-level", "doi": "10.1186/s12891-025-08275-x", "risk_of_bias": "not appraised in public sidecar", "study": "Concurrent effects of high-intensity interval training and vitamin D supplementation on bone metabolism among women diagnosed with osteoporosis: a randomized controlled trial"}, {"directness": "review-level", "doi": "10.3390/nu17182991", "risk_of_bias": "not appraised in public sidecar", "study": "Effectiveness of Vitamin D Supplementation on Biochemical, Clinical, and Inflammatory Parameters in Patients with Different Types of Diabetes: A Systematic Review and Meta-Analysis"}, {"directness": "review-level", "doi": "10.3389/fnut.2025.1505616", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D supplementation in critically ill patients: a meta-analysis"}, {"directness": "review-level", "doi": "10.1002/prp2.70013", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of vitamin D supplementation on clinical outcomes in adult patients with COVID‐19: A GRADE‐assessed systematic review and meta‐analysis of randomized controlled trials"}, {"directness": "review-level", "doi": "10.3390/nu17152489", "risk_of_bias": "not appraised in public sidecar", "study": "The Impact of Vitamin D Supplementation on Fasting Plasma Glucose, Insulin Sensitivity, and Inflammation in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis"}, {"directness": "review-level", "doi": "10.1186/s12872-025-05223-4", "risk_of_bias": "not appraised in public sidecar", "study": "Role of vitamin D supplementation in prevention of new onset atrial fibrillation in post-coronary artery bypass graft patients in vitamin D deficient and insufficient populations: a systematic review and meta-analysis"}, {"directness": "review-level", "doi": "10.1097/MD.0000000000046892", "risk_of_bias": "not appraised in public sidecar", "study": "A meta-analysis of the effects of vitamin D supplementation on endocrine metabolic and inflammatory markers in patients with polycystic ovarian syndrome"}, {"directness": "review-level", "doi": "10.3389/fnut.2025.1663019", "risk_of_bias": "not appraised in public sidecar", "study": "Dose–response effects of vitamin D supplementation on vitamin D status, glycosylated hemoglobin and total cholesterol in patients with diabetes mellitus: a systematic review and meta-analysis"}, {"directness": "review-level", "doi": "10.1093/nutrit/nuaf117", "risk_of_bias": "not appraised in public sidecar", "study": "Role of Vitamin D Supplementation in Chronic Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"}, {"directness": "primary", "doi": "10.1210/endrev/bnaf001", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Maternal Vitamin D Supplementation on Childhood Health"}, {"directness": "review-level", "doi": "10.1186/s40795-025-01060-y", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of the vitamin D supplementation on clinical outcomes and inflammatory status in COVID-19 patients: an umbrella review"}, {"directness": "primary", "doi": "10.1093/ajcn/nqab419", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial: a randomized controlled trial"}, {"directness": "review-level", "doi": "10.1007/s40520-025-02938-4", "risk_of_bias": "not appraised in public sidecar", "study": "Falls and physical function in older patients with Benign Paroxysmal Positional Vertigo (BPPV): findings from a placebo controlled, double blinded randomized control trial (RCT) investigating efficacy of vitamin D treatment in lowering the recurrence rate of BPPV"}, {"directness": "primary", "doi": "10.1136/bmj-2023-075230", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial"}, {"directness": "review-level", "doi": "10.3389/fnut.2025.1563604", "risk_of_bias": "not appraised in public sidecar", "study": "The effects of magnesium and vitamin D/E co-supplementation on inflammation markers and lipid metabolism of obese/overweight population: a systematic review and meta-analysis"}, {"directness": "primary", "doi": "10.1080/15502783.2025.2561661", "risk_of_bias": "not appraised in public sidecar", "study": "Single high-dose vitamin D supplementation impacts ultramarathon-induced changes in serum levels of bone turnover markers: a double-blind randomized controlled trial"}, {"directness": "review-level", "doi": "10.3390/nu15081810", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D Supplementation and Its Impact on Mortality and Cardiovascular Outcomes: Systematic Review and Meta-Analysis of 80 Randomized Clinical Trials"}, {"directness": "review-level", "doi": "10.1371/journal.pmed.1003999", "risk_of_bias": "not appraised in public sidecar", "study": "High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): A multicenter, open-label, randomized controlled superiority trial"}, {"directness": "primary", "doi": "10.3389/fimmu.2022.869591", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D Supplementation Modulates Platelet-Mediated Inflammation in Subjects With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial"}, {"directness": "review-level", "doi": "10.3390/nu18020357", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of Vitamin D Supplementation on Cardiometabolic Outcomes in Older Australian Adults—Results from the Randomized Controlled D-Health Trial"}, {"directness": "review-level", "doi": "10.3389/fmed.2026.1743776", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of vitamin D supplementation on glucose metabolism and pregnancy outcomes in GDM: a systematic review and meta-analysis"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2026.7332", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D Receptor Polymorphisms and the Effect of Vitamin D Supplementation on Diabetes Risk Among Adults With Prediabetes"}, {"directness": "review-level", "doi": "10.3389/fnut.2025.1559471", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of vitamin D supplementation on COVID-19 outcomes: an umbrella review of systematic reviews"}, {"directness": "primary", "doi": "10.1016/j.jnha.2025.100661", "risk_of_bias": "not appraised in public sidecar", "study": "Association between ionized calcium levels and 3-months mortality in geriatric patients hospitalized for COVID-19"}, {"directness": "review-level", "doi": "10.3390/nu18101560", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D Supplementation in Children with Asthma: An Umbrella Review"}, {"directness": "review-level", "doi": "10.1038/s41372-025-02440-9", "risk_of_bias": "not appraised in public sidecar", "study": "Short-term and long-term effects of vitamin D supplementation for preterm infants: a systematic review and meta-analysis"}, {"directness": "review-level", "doi": "10.1136/bmjopen-2024-098723", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of vitamin D supplementation during pregnancy and lactation on the development of infants born to Tanzanian women living with HIV: a secondary analysis of a randomised controlled trial"}, {"directness": "primary", "doi": "10.1161/JAHA.120.017727", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Vitamin D Supplementation on Cardiovascular and Glycemic Biomarkers"}, {"directness": "review-level", "doi": "10.3390/nu15030521", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Whey Protein, Leucine, and Vitamin D Supplementation in Patients with Sarcopenia: A Systematic Review and Meta-Analysis"}, {"directness": "primary", "doi": "10.3389/fendo.2025.1700844", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D supplementation and its impact on leptin and interleukin-6 in women following religious intermittent fasting: a controlled study"}, {"directness": "primary", "doi": "10.3390/nu18010175", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of High-Dose Vitamin D Supplementation and Physical Exercise on Vitamin D Metabolites in Professional Football Players: A Pilot Study"}, {"directness": "review-level", "doi": "10.3390/nu17172794", "risk_of_bias": "not appraised in public sidecar", "study": "A Systematic Review and Meta-Analysis of the Effects of Vitamin D on Systemic Lupus Erythematosus"}, {"directness": "primary", "doi": "10.1097/MD.0000000000047888", "risk_of_bias": "not appraised in public sidecar", "study": "Different response to vitamin D supplementation in children with RVOT morphology PVCs vs LV fascicular PVCs"}, {"directness": "review-level", "doi": "10.1186/s40795-025-01046-w", "risk_of_bias": "not appraised in public sidecar", "study": "The health outcomes of vitamin D supplementation in Africa: a systematic review and meta-analysis"}, {"directness": "primary", "doi": "10.1186/s12877-025-06189-w", "risk_of_bias": "not appraised in public sidecar", "study": "Inappropriate vitamin D supplementation among multimorbid older patients: a multicountry analysis"}, {"directness": "primary", "doi": "10.3390/ijerph22111695", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Resistance Training Combined with Vitamin D Supplementation on Health-Related Variables in the Elderly: Muscle Strength, Body Composition, and Inflammatory Status"}, {"directness": "review-level", "doi": "10.3390/nu17243866", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Combined Exercise and Calcium/Vitamin D Supplementation on Bone Mineral Density in Postmenopausal Women: A Systematic Review and Meta-Analysis"}, {"directness": "review-level", "doi": "10.3389/fmed.2024.1467234", "risk_of_bias": "not appraised in public sidecar", "study": "Efficacy of vitamin D supplementation on depressive symptoms in older patients: a meta-analysis of randomized controlled trials"}, {"directness": "review-level", "doi": "10.3389/fnut.2026.1772451", "risk_of_bias": "not appraised in public sidecar", "study": "Efficacy of vitamin D supplementation in patients diagnosed with depression: a dose–response meta-analysis of randomized controlled trials"}, {"directness": "review-level", "doi": "10.1136/bmjopen-2024-091903", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D supplementation for managing COVID-19 in patients with vitamin D deficiency: a systematic review and meta-analysis of randomised controlled trials"}, {"directness": "review-level", "doi": "10.52225/narra.v5i2.1848", "risk_of_bias": "not appraised in public sidecar", "study": "Impact of vitamin D supplementation on post-stroke rehabilitation outcomes: A systematic review and meta-analysis"}, {"directness": "review-level", "doi": "10.3390/nu18060968", "risk_of_bias": "not appraised in public sidecar", "study": "The Association Between Vitamin D and Polycystic Ovary Syndrome (PCOS) in Women: A Systematic Review"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2023.24465", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment"}, {"directness": "review-level", "doi": "10.17305/bb.2025.12527", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D supplementation for tuberculosis prevention: A meta-analysis"}, {"directness": "review-level", "doi": "10.1186/s40001-025-02412-x", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D and calcium supplementation in women undergoing pharmacological management for postmenopausal osteoporosis: a level I of evidence systematic review"}, {"directness": "review-level", "doi": "10.3389/fnagi.2024.1333217", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D supplementation in later life: a systematic review of efficacy and safety in movement disorders"}, {"directness": "review-level", "doi": "10.3389/fnut.2025.1500875", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of vitamin D supplementation on motor symptoms in Parkinson’s disease: a meta-analysis of randomized controlled trials"}, {"directness": "review-level", "doi": "10.3389/fnut.2025.1664960", "risk_of_bias": "not appraised in public sidecar", "study": "Can Vitamin D supplementation enhance the effectiveness of exercise-induced weight loss in overweight or obese adults? Evidence from integrated transcriptomic and meta-analysis"}, {"directness": "review-level", "doi": "10.3390/nu17203232", "risk_of_bias": "not appraised in public sidecar", "study": "Does Vitamin D Supplementation Impact Fibromyalgia-Related Pain? A Systematic Review and Meta-Analysis"}, {"directness": "primary", "doi": "10.1111/dom.14299", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of whey protein plus vitamin D supplementation combined with progressive resistance training on glycaemic control, body composition, muscle function and cardiometabolic risk factors in middle-aged and older overweight/obese adults with type 2 diabetes: A 24-week randomized controlled trial."}, {"directness": "primary", "doi": "10.3390/nu17091512", "risk_of_bias": "not appraised in public sidecar", "study": "The Role of Vitamin D Supplementation in Enhancing Muscle Strength Post-Surgery: A Systemic Review"}, {"directness": "primary", "doi": "10.3233/jad-200926", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial."}, {"directness": "review-level", "doi": "10.1055/s-0044-101355", "risk_of_bias": "not appraised in public sidecar", "study": "The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress Among Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"}, {"directness": "review-level", "doi": "10.1046/j.1532-5415.2003.51561.x", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Vitamin D Supplementation on Strength, Physical Function, and Health Perception in Older, Community‐Dwelling Men"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "c1cbca14-3224-46cc-bd1f-bc4a92a69d25",
  "researka_submission_id": "e14a0981-29f2-4f2d-b5b6-b4fd8f4a8ec1",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/c1cbca14-3224-46cc-bd1f-bc4a92a69d25/sidecars/risk_of_bias.json"
}