Derivation Web

source_54ac9df12ac5404f

by researka:v2 · 2026-06-25 04:28:59.800349+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Senolytic Drug Navitoclax Protects the Brain After Experimental Ischemic Stroke,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Senolytic Treatment With Fisetin Reverses Age‐Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Senolytic-loaded asymmetric wound dressing for targeted senescent cell clearance in diabetic wound healing,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Supramolecular delivery of senolytics enables targeted anti-senescence therapy and accelerated fracture healing,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Reevaluating the senolytic activity of a GLS1 inhibitor and an anti-PD-1 antibody: toward greater reproducibility and methodological rigor,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Is exercise a senolytic medicine? A systematic review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Dasatinib and quercetin senolytic treatment delays early onset intervertebral disc degeneration in SM/J mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Synergistic targeting of senolytic and senomorphic action with dual-engineered biomimetic macrophage nanovesicles for mitigating osteoarthritis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Senolytics alleviate cyclophosphamide-induced premature ovarian insufficiency by eliminating senescent cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Senolytic‐Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Preliminary Data on the Senolytic Effects of Agrimonia pilosa Ledeb. Extract Containing Agrimols for Immunosenescence in Middle-Aged Humans: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Senolytic Treatment With Dasatinib and Quercetin Reshapes Influenza‐Specific CD8 T Cell Responses During Infection in Aged, Vaccinated Mice",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Synergistic senolytic–regenerative therapy significantly extends healthspan and lifespan,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Natural senolytic activity of Rhodiola rosea extract alleviates age-associated phenotypes via paraptosis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Senolytic Therapy to Modulate the Progression of Alzheimer’s Disease (SToMP-AD): A Pilot Clinical Trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effect of Natural Senolytic Agents & NLRP3 Inhibitors on Osteoarthritis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Senolytic Treatment Reduces Acute and Chronic Lung Inflammation in an Aged Mouse Model of Influenza,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Protocol for a pilot clinical trial of the senolytic drug combination Dasatinib Plus Quercetin to mitigate age-related health and cognitive decline in mental disorders,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Senolytic effects of exercise in human muscles require acute inflammation.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Senolytic treatment with fisetin reverses age-related endothelial dysfunction partially mediated by SASP factor CXCL12,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APP NL-F/NL-F Mice",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effect of senolytic drugs in young female mice chemically induced to estropause,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Senolytic and senomorphic secondary metabolites as therapeutic agents in Drosophila melanogaster models of Parkinson’s disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Effect of Natural Senolytic 2024,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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