Derivation Web

source_5571ebf361d54894

by researka:v2 · 2026-06-20 16:56:32.953553+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "f7b01234-38e2-4b03-b28b-707000e0635b", "sources": [{"directness": "primary", "doi": "10.1093/nar/gkac123", "risk_of_bias": "not appraised in public sidecar", "study": "Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing"}, {"directness": "primary", "doi": "10.1038/s41467-020-14362-5", "risk_of_bias": "not appraised in public sidecar", "study": "Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing"}, {"directness": "primary", "doi": "10.1093/nar/gkad1108", "risk_of_bias": "not appraised in public sidecar", "study": "A modular dCas9-based recruitment platform for combinatorial epigenome editing"}, {"directness": "primary", "doi": "10.1093/hmg/ddab255", "risk_of_bias": "not appraised in public sidecar", "study": "Expanded CAG/CTG repeats resist gene silencing mediated by targeted epigenome editing"}, {"directness": "primary", "doi": "10.1093/nar/gkae798", "risk_of_bias": "not appraised in public sidecar", "study": "Chem-CRISPR/dCas9 FCPF : a platform for chemically induced epigenome editing"}, {"directness": "primary", "doi": "10.1038/s41467-025-63167-x", "risk_of_bias": "not appraised in public sidecar", "study": "Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins"}, {"directness": "primary", "doi": "10.1038/s41467-025-64932-8", "risk_of_bias": "not appraised in public sidecar", "study": "Rescue of imprinted genes by epigenome editing in human cellular models of Prader-Willi syndrome"}, {"directness": "primary", "doi": "10.3390/genes15010080", "risk_of_bias": "not appraised in public sidecar", "study": "Locus-Specific and Stable DNA Demethylation at the H19 / IGF2 ICR1 by Epigenome Editing Using a dCas9-SunTag System and the Catalytic Domain of TET1"}, {"directness": "primary", "doi": "10.1038/s41598-020-62035-6", "risk_of_bias": "not appraised in public sidecar", "study": "Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing"}, {"directness": "primary", "doi": "10.1186/s13072-022-00474-3", "risk_of_bias": "not appraised in public sidecar", "study": "Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system"}, {"directness": "primary", "doi": "10.1093/nar/gkae761", "risk_of_bias": "not appraised in public sidecar", "study": "Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency"}, {"directness": "primary", "doi": "10.1002/advs.202503917", "risk_of_bias": "not appraised in public sidecar", "study": "A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis ‐regulatory Modules"}, {"directness": "primary", "doi": "10.1038/s41598-021-95398-5", "risk_of_bias": "not appraised in public sidecar", "study": "Investigating crosstalk between H3K27 acetylation and H3K4 trimethylation in CRISPR/dCas-based epigenome editing and gene activation"}, {"directness": "primary", "doi": "10.7554/eLife.92991", "risk_of_bias": "not appraised in public sidecar", "study": "Predicting the effect of CRISPR-Cas9-based epigenome editing"}, {"directness": "primary", "doi": "10.1101/gr.233049.117", "risk_of_bias": "not appraised in public sidecar", "study": "A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs"}, {"directness": "primary", "doi": "10.1186/s12915-019-0711-z", "risk_of_bias": "not appraised in public sidecar", "study": "Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1001/jama.2010.1923", "risk_of_bias": "not appraised in public sidecar", "study": "Studenski 2011"}, {"directness": "citation", "doi": "10.1093/gerona/glp012", "risk_of_bias": "not appraised in public sidecar", "study": "Cesari 2009"}, {"directness": "citation", "doi": "10.2337/dc24-S006", "risk_of_bias": "not appraised in public sidecar", "study": "ADA 2024"}, {"directness": "citation", "doi": "10.1093/ageing/afy169", "risk_of_bias": "not appraised in public sidecar", "study": "Cruz-Jentoft 2019"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "Anisimov 2008"}, {"directness": "citation", "doi": "10.1056/NEJM198812293192604", "risk_of_bias": "not appraised in public sidecar", "study": "Tinetti 1988"}, {"directness": "citation", "doi": "10.1056/NEJMoa1504347", "risk_of_bias": "not appraised in public sidecar", "study": "Tancredi 2015"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

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