Derivation Web

source_56c90ffdd5f24057

by researka:v2 · 2026-06-24 05:56:25.885784+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Pharmacogenomic insights into atorvastatin and rosuvastatin adverse effects: a prospective observational study in the UAE’s multiethnic population,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The impact of statin use on colorectal cancer prognosis: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Alzheimer's disease in patients prescribed statins: A real-world data analysis of U.S. patient health records,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The association between statins and gait speed reserve in older adults: effects of concomitant medication,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
APOE genotype and the effect of statins on lipid outcomes: A meta‐analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases: A systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
A Meta-Analysis of the Incidence of Adverse Reactions of Statins in Various Diseases,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Pre-morbid statin use and mortality in trauma: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Comparative Effectiveness of Cholesteryl Ester Transfer Protein (CETP) Inhibitors on Lipid Profiles in Adults With Hyperlipidemia: A Comprehensive Systematic Review and Frequentist Network Meta‐Analysis of Randomized Controlled Trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Exploring the association between statins use or HMG-CoA reductase inhibition and migraine: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Reno-protective effects of statins among patients with chronic kidney disease in Hong Kong: a target trial emulation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Pemafibrate for hypertriglyceridemia: a meta-analysis of randomized controlled trials evaluating efficacy and safety outcomes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Comparative effectiveness of statins for chronic obstructive pulmonary disease patients with pulmonary hypertension: systematic review and network meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
LDL-C Goal Attainment with Fixed-Dose Ezetimibe and Atorvastatin Versus High-Dose Atorvastatin in Chinese Patients: Subgroup Analysis of a Randomized Trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effectiveness of combining PCSK9 inhibitors with statins on major adverse cardiovascular events and lipid levels in patients after percutaneous coronary intervention: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Prognostic Implication of LDL-C Variability and Its Association with Lipid-Lowering Strategies: Insights from the RACING and LODESTAR Trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Impact of Statin Use on Sepsis Mortality: A Systematic Review and Meta-Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Adjunctive Use of Locally Delivered Statins in Periodontal Therapy and Pre‐Implant Bone Regeneration: A Systematic Review and Meta‐Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effect of Statin Intensity on Cardiovascular Outcomes and Survival Following Coronary Artery Bypass Grafting,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
High-dose statins for the prevention of recurrent ischemic stroke: a systematic review and meta-analysis of randomized controlled trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
The role of statins during pregnancy on maternal risk of preeclampsia: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Exploring the relationship between atorvastatin and rosuvastatin use and respiratory, thoracic, and mediastinal disorders: A retrospective study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
ROLE OF STATINS IN CIRRHOTIC PORTAL HYPERTENSION: META-ANALYSIS OF RANDOMIZED STUDIES,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Efficacy, safety and cost-effectiveness of 40 mg versus 80 mg atorvastatin in a Sri Lankan cohort with acute coronary syndrome: a protocol for a single-centre randomised controlled clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Myasthenia Gravis Outcomes After Use of Statins and Other Contraindicated Treatments: Results From the French National Insurance Database,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effect of lifestyle modification and atorvastatin on dyslipidemia and endothelial dysfunction markers in children with steroid resistant nephrotic syndrome,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Integrative Proteomic and Lipidomic Analysis of Patients With Acute Myocardial Infarction Treated With PCSK9 Antibodies and Statins,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The role of statins in modulating subclinical inflammatory markers in coronary slow flow phenomenon,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rationale and design of ‘discontinuing statins in multimorbid older adults without cardiovascular disease (STREAM)’: study protocol of a randomised non-inferiority clinical trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Recurrent Symptomatic Hemorrhage in Cerebral Cavernous Malformations After Discontinuation of Atorvastatin or Placebo,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rationale and Design of the EPISODE Trial: A Randomized Controlled Trial on the Effect of PCSK9 Inhibitors in Calcific Aortic Valve Stenosis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The role of statins in dementia or Alzheimer’s disease incidence: a systematic review and meta-analysis of cohort studies,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Clinical efficacy of combining fenofibrate with statins in patients with diabetes and hyperlipidemia: a meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Efficacy and safety of statins, ezetimibe, and fibrates monotherapy or combination therapy for hyperlipidemia: a systematic review and network meta-analysis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Ezetimibe and the risk of new-onset type 2 diabetes: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Prognostic role of statins in colorectal cancer: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effect of atorvastatin versus no S tatin T reatment on major clinical events in A cute C ardio E mbolic stroke patients without a definite indication for statin therapy: protocol for the STACE trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Assessing the Role of Statins as an Adjunctive Anti-VEGF Therapy for Clinically Significant Macular Edema (CSME) in Type 2 Diabetes Mellitus,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effect of statins on neurological functional outcomes in critically ill adult patients with traumatic brain injury: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Lipid-lowering effect of combined therapy with high-intensity statins and CETP inhibitors: a Systematic Review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effectiveness of Statins for Oxaliplatin‐Induced Peripheral Neuropathy: A Multicenter Retrospective Observational Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The antitumoral effect of statins in pancreatic ductal adenocarcinoma: a scoping review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Pragmatic trial assessing polygenic risk driven statin therapy for cardiovascular disease prevention: study protocol for the EE-PRS trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Trust first, concerns second: An international vignette study of older adults' preferences towards deprescribing statins",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Slowing Thoracic Aortic Aneurysm Growth with Statins: A Meta-Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Statin effect on arrhythmogenic cardiomyopathy disease progression (SEARCH): Randomized clinical study protocol,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
HMG‐CoA reductase inhibitors (statins) versus placebo for people with schizophrenia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The effect of statins on the survival of patients with amyotrophic lateral sclerosis: a meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Preclinical efficacy and mechanisms of statin-loaded polymeric nanocapsules: a meta-analysis of tumor lipid metabolism inhibition,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Advances in statin adverse reactions and the potential mechanisms: A systematic review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
The Potential Role of Statins in Infective Endocarditis: A Meta-Analysis.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
STREAM Trial - Biomarker,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
STREAM Trial Biomarker 2026,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Studenski 2011,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Bohannon 1997,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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