Derivation Web

source_56e2d98adb564c26

by researka:v2 · 2026-06-23 20:29:36.787025+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Melatonin administered postoperatively lowers oxidative stress and inflammation and significantly recovers heart function in patients undergoing CABG surgery,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effects of melatonin on advanced glycation end products, inflammation, and oxidative stress in peritoneal dialysis patients: a randomized controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Exploring the role of melatonin in managing sleep and motor symptoms in Parkinson’s disease: a pooled analysis of double-blinded randomized controlled trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose–Response Meta-Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Melatonin ameliorates inflammation and improves outcomes of ischemia/reperfusion injury in patients undergoing coronary artery bypass grafting surgery: a randomized placebo-controlled study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A Series of Personalized Melatonin Supplement Interventions for Poor Sleep: Feasibility Randomized Crossover Trial for Personalized N-of-1 Treatment,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Melatonin, Caffeine, or Their Combination: Effects on Sleep, Performance, Perceived Exertion in a Placebo-Controlled Crossover Study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Evaluating the antioxidant and anti-inflammatory effect of melatonin in pediatric hemodialysis patients: a randomized, placebo-controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Pharmacologic neuroprotective agents for the treatment of perinatal asphyxia in low-income and lower-middle-income countries: A systematic review and meta-analysis of randomised controlled trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Melatonin agonist tasimelteon (HETLIOZ ® ) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, placebo-controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effect of melatonin versus placebo for the prevention of delirium among medically hospitalised older patients: a double-blinded randomised controlled trial (project RESTORE),not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Hepatic Safety of Adjunctive High-Dose Melatonin in Participants Receiving Ocrelizumab for Primary Progressive Multiple Sclerosis: Liver Toxicity Findings from a Phase I/II Randomised Clinical Trial (MELATOMS-1),not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Melatonin supplementation reduces delirium incidence in critically ill patients: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Timing-dependent effects of melatonin supplementation on exercise performance and exercise-induced muscle damage: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Melatonin Regulates Arylhydrocarbon Receptor Mediated UVR‐Induced Processes Related to Inflammation, Skin Aging and Carcinogenesis in Human Ex Vivo Skin",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Melatonin for prevention of delirium in patients receiving mechanical ventilation in the intensive care unit: a multiarm multistage adaptive randomized controlled clinical trial (DEMEL),not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Oral Melatonin in Critically Ill Patients With COVID‐19: A Quasi‐Experimental Pragmatic Trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Melatonin as a Possible Stimulus to Unmask an Oxytocin-Deficient State in Hypopituitarism and Hypothalamic Damage,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effect of melatonin versus placebo for prevention of delirium among medically hospitalised patients: study protocol for a single-centre, double-blinded, randomised controlled trial (project RESTORE)",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sleep quality and sleepiness in adults with multiple myeloma. Is melatonin a potential treatment?,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"A systematic review and meta-analysis of randomized controlled trials investigated the effects of melatonin supplementation on bone mineral density, quality of life, and sleep in menopausal women",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effect of melatonin on cognitive function in adults with cognitive impairment: a multi-dimensional meta-analysis of randomized trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Melatonin Use in Young Children,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Acute High Dose Melatonin for Encephalopathy of the Newborn (ACUMEN) Study: a protocol for a multicentre phase 1 safety trial of melatonin to augment therapeutic hypothermia for moderate/severe hypoxic ischaemic encephalopathy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Transcutaneous auricular vagal nerve stimulation improves functional dyspepsia with sleep disturbance via enhanced vagal activity: a randomized controlled trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"The effect of melatonin supplementation on lipid profile, oxidative stress, inflammatory marker, and sleep quality in patients with chronic kidney disease: a GRADE assessed meta-analysis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Preoperative 15 mg of melatonin for reducing anxiety and post-traumatic stress disorder symptoms in mandibular third molar surgery: A randomized double-blind placebo-controlled clinical trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Melatonin for preventing postoperative delirium in elderly patients: A multicenter randomized placebo-controlled pilot study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
A prospective randomized crossover trial investigating melatonin versus sleep deprivation for sleep induction in nap electroencephalography,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Melatonin improved the outcomes of women with ART: a systematic review and meta-analysis of randomized trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Exogenous melatonin boosts vaccine-induced immunity in individuals with high pre-existing influenza immunity,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Melatonin supplementation for quality of life in older patients with advanced cancer: a randomized controlled trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The effects of melatonin on follicular oxidative stress and art outcomes in women with diminished ovarian reserve: a randomized controlled trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Low‐Dose Melatonin, Climacteric Symptoms and Sleep in Female Shift Workers: A Randomized Controlled Trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effectiveness of melatonin supplementation for improving sleep quality and disease severity in children with atopic dermatitis: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Clinical and radiographic evaluation of melatonin and chitosan loaded nanoparticles in the treatment of periodontal intra-bony defects: A Randomized controlled clinical trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Dysregulation of melatonin rhythm in Parkinson’s and Huntington’s disease: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparous women: the MyTIME study protocol",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Melatonin for blood pressure control in adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effect of peri‐operative pharmacological interventions on postoperative delirium in patients having cardiac surgery: a systematic review and Bayesian network meta‐analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Comparing Intranasal Midazolam, Oral Melatonin, and Distraction Cards for Pain and Stress Management in Pediatric Intravenous Line Insertion: A Randomized Controlled Trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over‐the‐Counter Products for Male Androgenetic Alopecia: A Network Meta‐Analysis Study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Melatonin and sleep parameters in infertile women with endometriosis: first results from the triple-blind randomized controlled trial of administration of melatonin in chronic pelvic pain and sleep disturbance,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The effect of melatonin supplementation on glycemic control in patients with type 2 diabetes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Melatonin for chronic back pain (the MOCHA trial): study protocol for a randomized, double-blind, placebo-controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Association of physical activity and rest-activity rhythm with sustained attention and melatonin among community-dwelling older adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Status of research on the application of melatonin in insomnia based on bibliometric visualization analysis and development trends,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The feasibility of salivary melatonin in assessing perioperative circadian rhythm in surgical patients: study protocol for a multicentre prospective study in China,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Benefits of melatonin on mortality in severe-to-critical COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Anisimov 2008,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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